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Science 19 November 1999:
Vol. 286. no. 5444, pp. 1571 - 1577
DOI: 10.1126/science.286.5444.1571
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Reports

Genome Sequence of the Radioresistant Bacterium Deinococcus radiodurans R1

Owen White, 1 Jonathan A. Eisen, 1 John F. Heidelberg, 1 Erin K. Hickey, 1 Jeremy D. Peterson, 1 Robert J. Dodson, 1 Daniel H. Haft, 1 Michelle L. Gwinn, 1 William C. Nelson, 1 Delwood L. Richardson, 1 Kelly S. Moffat, 1 Haiying Qin, 1 Lingxia Jiang, 1 Wanda Pamphile, 1 Marie Crosby, 1 Mian Shen, 1 Jessica J. Vamathevan, 1 Peter Lam, 1 Lisa McDonald, 1 Terry Utterback, 1 Celeste Zalewski, 1 Kira S. Makarova, 2 L. Aravind, 2 Michael J. Daly, 3 Kenneth W. Minton, 3 Robert D. Fleischmann, 1 Karen A. Ketchum, 1 Karen E. Nelson, 1 Steven Salzberg, 1 Hamilton O. Smith, 1* J. Craig , Venter, 1* Claire M. Fraser 1dagger

The complete genome sequence of the radiation-resistant bacterium Deinococcus radiodurans R1 is composed of two chromosomes (2,648,638 and 412,348 base pairs), a megaplasmid (177,466 base pairs), and a small plasmid (45,704 base pairs), yielding a total genome of 3,284,156 base pairs. Multiple components distributed on the chromosomes and megaplasmid that contribute to the ability of D. radiodurans to survive under conditions of starvation, oxidative stress, and high amounts of DNA damage were identified. Deinococcus radiodurans represents an organism in which all systems for DNA repair, DNA damage export, desiccation and starvation recovery, and genetic redundancy are present in one cell.

1 The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.
2 National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894, USA.
3 Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
*   Present address: Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA.

dagger    To whom correspondence should be addressed. E-mail: drdb{at}tigr.org

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The IrrE Protein of Deinococcus radiodurans R1 Is a Novel Regulator of recA Expression.
A. M. Earl, M. M. Mohundro, I. S. Mian, and J. R. Battista (2002)
J. Bacteriol. 184, 6216-6224
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Protein Splicing of the Deinococcus radiodurans Strain R1 Snf2 Intein.
M. W. Southworth and F. B. Perler (2002)
J. Bacteriol. 184, 6387-6388
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Comparative Proteome Analysis of Brucella melitensis Vaccine Strain Rev 1 and a Virulent Strain, 16M.
M. Eschenbrenner, M. A. Wagner, T. A. Horn, J. A. Kraycer, C. V. Mujer, S. Hagius, P. Elzer, and V. G. DelVecchio (2002)
J. Bacteriol. 184, 4962-4970
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The Fibronectin Type 3-Like Repeat from the Clostridium thermocellum Cellobiohydrolase CbhA Promotes Hydrolysis of Cellulose by Modifying Its Surface.
I. A. Kataeva, R. D. Seidel III, A. Shah, L. T. West, X.-L. Li, and L. G. Ljungdahl (2002)
Appl. Envir. Microbiol. 68, 4292-4300
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SipY Is the Streptomyces lividans Type I Signal Peptidase Exerting a Major Effect on Protein Secretion.
A. Palacin, V. Parro, N. Geukens, J. Anne, and R. P. Mellado (2002)
J. Bacteriol. 184, 4875-4880
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Disruption analysis of DR1420 and/or DR1758 in the extremely radioresistant bacterium Deinococcus radiodurans.
H. Nishida and I. Narumi (2002)
Microbiology 148, 2911-2914
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Dictionary-driven protein annotation.
I. Rigoutsos, T. Huynh, A. Floratos, L. Parida, and D. Platt (2002)
Nucleic Acids Res. 30, 3901-3916
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New technology may reveal mechanisms of radiation resistance in Deinococcus radiodurans.
J. Mrazek (2002)
PNAS 99, 10943-10944
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From the Cover: Global analysis of the Deinococcus radiodurans proteome by using accurate mass tags.
M. S. Lipton, L. Pasa-Tolic', G. A. Anderson, D. J. Anderson, D. L. Auberry, J. R. Battista, M. J. Daly, J. Fredrickson, K. K. Hixson, H. Kostandarithes, et al. (2002)
PNAS 99, 11049-11054
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Identification of the {Omega}4514 Regulatory Region, a Developmental Promoter of Myxococcus xanthus That Is Transcribed In Vitro by the Major Vegetative RNA Polymerase.
T. Hao, D. Biran, G. J. Velicer, and L. Kroos (2002)
J. Bacteriol. 184, 3348-3359
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Investigating the Relationship Between Genome Structure, Composition, and Ecology in Prokaryotes.
P. Lio (2002)
Mol. Biol. Evol. 19, 789-800
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Direct Evidence for Nitric Oxide Production by a Nitric-oxide Synthase-like Protein from Bacillus subtilis.
S. Adak, K. S. Aulak, and D. J. Stuehr (2002)
J. Biol. Chem. 277, 16167-16171
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Biosynthetic Gene Cluster of Simocyclinone, a Natural Multihybrid Antibiotic.
A. Trefzer, S. Pelzer, J. Schimana, S. Stockert, C. Bihlmaier, H.-P. Fiedler, K. Welzel, A. Vente, and A. Bechthold (2002)
Antimicrob. Agents Chemother. 46, 1174-1182
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