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Science 19 November 1999:
Vol. 286. no. 5444, pp. 1566 - 1568
DOI: 10.1126/science.286.5444.1566
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Reports

Modulation of Respiratory Frequency by Peptidergic Input to Rhythmogenic Neurons in the PreBötzinger Complex

Paul A. Gray, 13* Jens C. Rekling, 1* Christopher M. Bocchiaro, 2 Jack L. Feldman 12dagger

Neurokinin-1 receptor (NK1R) and µ-opioid receptor (µOR) agonists affected respiratory rhythm when injected directly into the preBötzinger Complex (preBötC), the hypothesized site for respiratory rhythmogenesis in mammals. These effects were mediated by actions on preBötC rhythmogenic neurons. The distribution of NK1R+ neurons anatomically defined the preBötC. Type 1 neurons in the preBötC, which have rhythmogenic properties, expressed both NK1Rs and µORs, whereas type 2 neurons expressed only NK1Rs. These findings suggest that the preBötC is a definable anatomic structure with unique physiological function and that a subpopulation of neurons expressing both NK1Rs and µORs generate respiratory rhythm and modulate respiratory frequency.

Departments of
1 Neurobiology and
2 Physiological Science and
3 Interdepartmental Ph.D. Program in Neuroscience, University of California Los Angeles, Box 951763, Los Angeles, CA 90095-1763, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: feldman{at}ucla.edu

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Models of Respiratory Rhythm Generation in the Pre-Botzinger Complex. III. Experimental Tests of Model Predictions.
C. A. Del Negro, S. M. Johnson, R. J. Butera, and J. C. Smith (2001)
J Neurophysiol 86, 59-74
   Abstract »    Full Text »    PDF »
Pre-Botzinger Neurons With Preinspiratory Discharges "In Vivo" Express NK1 Receptors in the Rat.
P. G. Guyenet and H. Wang (2001)
J Neurophysiol 86, 438-446
   Abstract »    Full Text »    PDF »
Mechanisms Underlying Regulation of Respiratory Pattern by Nicotine in PreBotzinger Complex.
X. M. Shao and J. L. Feldman (2001)
J Neurophysiol 85, 2461-2467
   Abstract »    Full Text »    PDF »
Acidosis-Stimulated Neurons of the Medullary Raphe Are Serotonergic.
W. Wang, J. K. Tiwari, S. R. Bradley, R. V. Zaykin, and G. B. Richerson (2001)
J Neurophysiol 85, 2224-2235
   Abstract »    Full Text »    PDF »
Location of central respiratory chemoreceptors in the developing tadpole.
C. S. Torgerson, M. J. Gdovin, R. Brandt, and J. E. Remmers (2001)
Am J Physiol Regulatory Integrative Comp Physiol 280, R921-R928
   Abstract »    Full Text »    PDF »
Developmental study of cytochrome oxidase activity in the brain stem respiratory nuclei of postnatal rats.
Y.-Y. Liu and M. T. T. Wong-Riley (2001)
J Appl Physiol 90, 685-694
   Abstract »    Full Text »    PDF »
Nucleus raphe obscurus modulates hypoglossal output of neonatal rat in vitro transverse brain stem slices.
J. H. Peever, A. Necakov, and J. Duffin (2001)
J Appl Physiol 90, 269-279
   Abstract »    Full Text »    PDF »
Role of Inspiratory Pacemaker Neurons in Mediating the Hypoxic Response of the Respiratory Network In Vitro.
M. Thoby-Brisson and J.-M. Ramirez (2000)
J. Neurosci. 20, 5858-5866
   Abstract »    Full Text »    PDF »
Acetylcholine Modulates Respiratory Pattern: Effects Mediated by M3-Like Receptors in PreBotzinger Complex Inspiratory Neurons.
X. M. Shao and J. L. Feldman (2000)
J Neurophysiol 83, 1243-1252
   Abstract »    Full Text »    PDF »


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