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Science 19 November 1999:
Vol. 286. no. 5444, pp. 1552 - 1554
DOI: 10.1126/science.286.5444.1552
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Reports

Feedback Connections to the Lateral Geniculate Nucleus and Cortical Response Properties

Penelope C. Murphy, 12* Simon G. Duckett, 1 Adam M. Sillito 2

The cerebral cortex receives sensory input from the periphery by means of thalamic relay nuclei, but the flow of information goes both ways. Each cortical area sends a reciprocal projection back to the thalamus. In the visual system, the synaptic relations that govern the influence of thalamic afferents on orientation selectivity in the cortex have been studied extensively. It now appears that the connectivity of the corticofugal feedback pathway is also fundamentally linked to the orientation preference of the cortical cells involved.

1 Department of Physiology, St. George's Hospital Medical School, Tooting, London SW17 0RE, UK.
2 Department of Visual Science, Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK.
*   To whom correspondence should be addressed. E-mail: p.murphy{at}sghms.ac.uk

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