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Science 12 November 1999:
Vol. 286. no. 5443, pp. 1381 - 1383
DOI: 10.1126/science.286.5443.1381
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Reports

Class II-Independent Generation of CD4 Memory T Cells from Effectors

Susan L. Swain, * Hui Hu, Gail Huston

The factors required for the generation of memory CD4 T cells remain unclear, and whether there is a continuing requirement for antigen stimulation is critical to design of vaccine strategies. CD4 effectors generated in vitro from naïve CD4 T cells of mice efficiently gave rise to small resting memory cells after transfer to class II-deficient hosts, indicating no requirement for further antigen or class II recognition.

Biomedical Research Laboratories, Trudeau Institute, 100 Algonquin Avenue, Saranac Lake, NY 12983, USA.
*   To whom correspondence should be addressed. E-mail: sswain{at}northnet.org

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