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Science 12 November 1999:
Vol. 286. no. 5443, pp. 1377 - 1381
DOI: 10.1126/science.286.5443.1377
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Reports

Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice

Kaja Murali-Krishna, 1 Lisa L. Lau, 1* Suryaprakash Sambhara, 2 Francois Lemonnier, 3 John Altman, 1 Rafi Ahmed 1dagger

An understanding of how T cell memory is maintained is crucial for the rational design of vaccines. Memory T cells were shown to persist indefinitely in major histocompatibility complex (MHC) class I-deficient mice and retained the ability to make rapid cytokine responses upon reencounter with antigen. In addition, memory CD8 T cells, unlike naïve cells, divided without MHC-T cell receptor interactions. This "homeostatic" proliferation is likely to be important in maintaining memory T cell numbers in the periphery. Thus, after naïve CD8 T cells differentiate into memory cells, they evolve an MHC class I-independent "life-style" and do not require further stimulation with specific or cross-reactive antigen for their maintenance.

1 Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.
2 Pasteur Merieux Connaught Canada, North York, Ontario M2R 3TA, Canada.
3 Departement du SIDA et des Retrovirus, Institut Pasteur, Paris 75724, France.
*   Present address: Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

dagger    To whom correspondence should be addressed. E-mail: ra{at}microbio.emory.edu

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Memory T Cells Originate from Adoptively Transferred Effectors and Reconstituting Host Cells after Sequential Lymphodepletion and Adoptive Immunotherapy.
L.-X. Wang, J. Kjaergaard, P. A. Cohen, S. Shu, and G. E. Plautz (2004)
J. Immunol. 172, 3462-3468
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Competition for self-peptide-MHC complexes and cytokines between naive and memory CD8+ T cells expressing the same or different T cell receptors.
Q. Ge, A. Bai, B. Jones, H. N. Eisen, and J. Chen (2004)
PNAS 101, 3041-3046
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Expansion of Protective CD8+ T-Cell Responses Driven by Recombinant Cytomegaloviruses.
U. Karrer, M. Wagner, S. Sierro, A. Oxenius, H. Hengel, T. Dumrese, S. Freigang, U. H. Koszinowski, R. E. Phillips, and P. Klenerman (2004)
J. Virol. 78, 2255-2264
   Abstract »    Full Text »    PDF »
Comprehensive Early and Lasting Loss of Memory CD8 T Cells and Functional Memory during Acute and Persistent Viral Infections.
S.-K. Kim and R. M. Welsh (2004)
J. Immunol. 172, 3139-3150
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The limits of protection by "memory" T cells in Ig-/- mice persistently infected with a {gamma}-herpesvirus.
S. Andreansky, H. Liu, H. Adler, U. H. Koszinowski, S. Efstathiou, and P. C. Doherty (2004)
PNAS 101, 2017-2022
   Abstract »    Full Text »    PDF »
A Role for TCR Affinity in Regulating Naive T Cell Homeostasis.
W. C. Kieper, J. T. Burghardt, and C. D. Surh (2004)
J. Immunol. 172, 40-44
   Abstract »    Full Text »    PDF »


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