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Science 29 October 1999:
Vol. 286. no. 5441, pp. 952 - 954
DOI: 10.1126/science.286.5441.952
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Reports

TCR-Mediated Internalization of Peptide-MHC Complexes Acquired by T Cells

Jing-Feng Huang, 1 Young Yang, 1 Homero Sepulveda, 1 Weixing Shi, 1 Inkyu Hwang, 2 Per A. Peterson, 1 Michael R. Jackson, 1 Jonathan Sprent, 2 Zeling Cai 1*

Peptide-major histocompatibility complex protein complexes (pMHCs) on antigen-presenting cells (APCs) are central to T cell activation. Within minutes of peptide-specific T cells interacting with APCs, pMHCs on APCs formed clusters at the site of T cell contact. Thereafter, these clusters were acquired by T cells and internalized through T cell receptor-mediated endocytosis. During this process, T cells became sensitive to peptide-specific lysis by neighboring T cells (fratricide). This form of immunoregulation could explain the "exhaustion" of T cell responses that is induced by high viral loads and may serve to down-regulate immune responses.

1 R. W. Johnson Pharmaceutical Research Institute, 3210 Merryfield Row, San Diego, CA 92121, USA.
2 Department of Immunology, IMM4, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
*   To whom correspondence should be addressed. E-mail: zcai{at}prius.jnj.com

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