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Science 15 October 1999:
Vol. 286. no. 5439, pp. 458 - 481
DOI: 10.1126/science.286.5439.458
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Review

The Promise of Comparative Genomics in Mammals

Stephen J. O'Brien, 1 Marilyn Menotti-Raymond, 1 William J. Murphy, 1 William G. Nash, 1 Johannes Wienberg, 1 Roscoe Stanyon, 1 Neal G. Copeland, 2 Nancy A. Jenkins, 2 James E. Womack, 3 Jennifer A. Marshall Graves 4

Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate-resolution maps of livestock, companion animals, and additional mammal species. Comparative genetic assessment expands the utility of these maps in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.

1 Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702-1201, USA.
2 Mammalian Genetics Laboratory, Advanced BioScience Laboratories, National Cancer Institute, Frederick, MD 21702-1201, USA.
3 Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843, USA.
4 Department of Genetics and Evolution, LaTrobe University, Melbourne, Victoria 3083, Australia.

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