Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 8 October 1999:
Vol. 286. no. 5438, pp. 312 - 315
DOI: 10.1126/science.286.5438.312
Prev | Table of Contents | Next

Reports

Congenital Nephrotic Syndrome in Mice Lacking CD2-Associated Protein

Neng-Yao Shih, 1* Jun Li, 1* Vladimir Karpitskii, 1 Ancho Nguyen, 1 Michael L. Dustin, 1 Osami Kanagawa, 1 Jeffrey H. Miner, 2 Andrey S. Shaw 1dagger

CD2-associated protein (CD2AP) is an 80-kilodalton protein that is critical for stabilizing contacts between T cells and antigen-presenting cells. In CD2AP-deficient mice, immune function was compromised, but the mice died at 6 to 7 weeks of age from renal failure. In the kidney, CD2AP was expressed primarily in glomerular epithelial cells. Knockout mice exhibited defects in epithelial cell foot processes, accompanied by mesangial cell hyperplasia and extracellular matrix deposition. Supporting a role for CD2AP in the specialized cell junction known as the slit diaphragm, CD2AP associated with nephrin, the primary component of the slit diaphragm.

1 Center for Immunology and Department of Pathology,
2 Department of Medicine, Renal Division, Washington University, Saint Louis, MO 63110, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: shaw{at}immunology.wustl.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Slit Diaphragms Contain Tight Junction Proteins.
H. Fukasawa, S. Bornheimer, K. Kudlicka, and M. G. Farquhar (2009)
J. Am. Soc. Nephrol. 20, 1491-1503
   Abstract »    Full Text »    PDF »
CD2AP mutations are associated with sporadic nephrotic syndrome and focal segmental glomerulosclerosis (FSGS).
M. Gigante, P. Pontrelli, E. Montemurno, L. Roca, F. Aucella, R. Penza, G. Caridi, E. Ranieri, G. M. Ghiggeri, and L. Gesualdo (2009)
Nephrol. Dial. Transplant. 24, 1858-1864
   Abstract »    Full Text »    PDF »
Loss of Podocyte aPKC{lambda}/{iota} Causes Polarity Defects and Nephrotic Syndrome.
T. B. Huber, B. Hartleben, K. Winkelmann, L. Schneider, J. U. Becker, M. Leitges, G. Walz, H. Haller, and M. Schiffer (2009)
J. Am. Soc. Nephrol. 20, 798-806
   Abstract »    Full Text »    PDF »
Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1.
Y. Harita, H. Kurihara, H. Kosako, T. Tezuka, T. Sekine, T. Igarashi, I. Ohsawa, S. Ohta, and S. Hattori (2009)
J. Biol. Chem. 284, 8951-8962
   Abstract »    Full Text »    PDF »
NPHS1 gene mutation in Japanese patients with congenital nephrotic syndrome.
K. Aya, J. Shimizu, Y. Ohtomo, K. Satomura, H. Suzuki, K. Yan, Y. Sado, T. Morishima, and H. Tanaka (2009)
Nephrol. Dial. Transplant.
   Abstract »    Full Text »    PDF »
Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats.
I. Matsui, T. Hamano, K. Tomida, K. Inoue, Y. Takabatake, Y. Nagasawa, N. Kawada, T. Ito, H. Kawachi, H. Rakugi, et al. (2009)
Nephrol. Dial. Transplant.
   Abstract »    Full Text »    PDF »
Lipid-Protein Interactions along the Slit Diaphragm of Podocytes.
B. Schermer and T. Benzing (2009)
J. Am. Soc. Nephrol. 20, 473-478
   Abstract »    Full Text »    PDF »
Podocyte-Specific Deletion of Dicer Alters Cytoskeletal Dynamics and Causes Glomerular Disease.
S. J. Harvey, G. Jarad, J. Cunningham, S. Goldberg, B. Schermer, B. D. Harfe, M. T. McManus, T. Benzing, and J. H. Miner (2008)
J. Am. Soc. Nephrol. 19, 2150-2158
   Abstract »    Full Text »    PDF »
Dissociation of NEPH1 from nephrin is involved in development of a rat model of focal segmental glomerulosclerosis.
Y. Otaki, N. Miyauchi, M. Higa, A. Takada, T. Kuroda, F. Gejyo, F. Shimizu, and H. Kawachi (2008)
Am J Physiol Renal Physiol 295, F1376-F1387
   Abstract »    Full Text »    PDF »
The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cells.
M. A. Saleem, J. Zavadil, M. Bailly, K. McGee, I. R. Witherden, H. Pavenstadt, H. Hsu, J. Sanday, S. C. Satchell, R. Lennon, et al. (2008)
Am J Physiol Renal Physiol 295, F959-F970
   Abstract »    Full Text »    PDF »
CD2AP and Cbl-3/Cbl-c Constitute a Critical Checkpoint in the Regulation of Ret Signal Transduction.
C. C. Tsui and B. A. Pierchala (2008)
J. Neurosci. 28, 8789-8800
   Abstract »    Full Text »    PDF »
Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome.
F. Duner, J. Patrakka, Z. Xiao, J. Larsson, A. Vlamis-Gardikas, E. Pettersson, K. Tryggvason, K. Hultenby, and A. Wernerson (2008)
Nephrol. Dial. Transplant. 23, 2504-2511
   Abstract »    Full Text »    PDF »
Neph1, a Component of the Kidney Slit Diaphragm, Is Tyrosine-phosphorylated by the Src Family Tyrosine Kinase and Modulates Intracellular Signaling by Binding to Grb2.
Y. Harita, H. Kurihara, H. Kosako, T. Tezuka, T. Sekine, T. Igarashi, and S. Hattori (2008)
J. Biol. Chem. 283, 9177-9186
   Abstract »    Full Text »    PDF »
Properties of the Glomerular Barrier and Mechanisms of Proteinuria.
B. Haraldsson, J. Nystrom, and W. M. Deen (2008)
Physiol Rev 88, 451-487
   Abstract »    Full Text »    PDF »
Novel markers of normal and neoplastic human plasmacytoid dendritic cells.
T. Marafioti, J. C. Paterson, E. Ballabio, K. K. Reichard, S. Tedoldi, K. Hollowood, M. Dictor, M.-L. Hansmann, S. A. Pileri, M. J. Dyer, et al. (2008)
Blood 111, 3778-3792
   Abstract »    Full Text »    PDF »
The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning.
R. I. Johnson, M. J. Seppa, and R. L. Cagan (2008)
J. Cell Biol. 180, 1191-1204
   Abstract »    Full Text »    PDF »
Amelioration of Crescentic Glomerulonephritis by RhoA Kinase Inhibitor, Fasudil, through Podocyte Protection and Prevention of Leukocyte Migration.
T. Hidaka, Y. Suzuki, M. Yamashita, T. Shibata, Y. Tanaka, S. Horikoshi, and Y. Tomino (2008)
Am. J. Pathol. 172, 603-614
   Abstract »    Full Text »    PDF »
Analysis of the Cell Adhesion Molecule Sticks-and-Stones Reveals Multiple Redundant Functional Domains, Protein-Interaction Motifs and Phosphorylated Tyrosines That Direct Myoblast Fusion in Drosophila melanogaster.
K. S. Kocherlakota, J.-m. Wu, J. McDermott, and S. M. Abmayr (2008)
Genetics 178, 1371-1383
   Abstract »    Full Text »    PDF »
Development of the renal glomerulus: good neighbors and good fences.
S. E. Quaggin and J. A. Kreidberg (2008)
Development 135, 609-620
   Abstract »    Full Text »    PDF »
The Glomerular Transcriptome and a Predicted Protein-Protein Interaction Network.
L. He, Y. Sun, M. Takemoto, J. Norlin, K. Tryggvason, T. Samuelsson, and C. Betsholtz (2008)
J. Am. Soc. Nephrol. 19, 260-268
   Abstract »    Full Text »    PDF »
Neph1 Cooperates with Nephrin To Transduce a Signal That Induces Actin Polymerization.
P. Garg, R. Verma, D. Nihalani, D. B. Johnstone, and L. B. Holzman (2007)
Mol. Cell. Biol. 27, 8698-8712
   Abstract »    Full Text »    PDF »
Rapid screening of glomerular slit diaphragm integrity in larval zebrafish.
D. M. Hentschel, M. Mengel, L. Boehme, F. Liebsch, C. Albertin, J. V. Bonventre, H. Haller, and M. Schiffer (2007)
Am J Physiol Renal Physiol 293, F1746-F1750
   Abstract »    Full Text »    PDF »
Molecular architecture of the glomerular slit diaphragm: lessons learnt for a better understanding of disease pathogenesis.
H. Holthofer (2007)
Nephrol. Dial. Transplant. 22, 2124-2128
   Full Text »    PDF »
Structure and function analysis of the CMS/CIN85 protein family identifies actin-bundling properties and heterotypic-complex formation.
G. Gaidos, S. Soni, D. J. Oswald, P. A. Toselli, and K. H. Kirsch (2007)
J. Cell Sci. 120, 2366-2377
   Abstract »    Full Text »    PDF »
Expression of filtrin in human glomerular diseases.
P. Ihalmo, H. Schmid, M. P. Rastaldi, D. Mattinzoli, R. G. Langham, P. Luimula, R. Kilpikari, M. Lassila, R. E. Gilbert, D. Kerjaschki, et al. (2007)
Nephrol. Dial. Transplant. 22, 1903-1909
   Abstract »    Full Text »    PDF »
Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes.
K. Asanuma, K. N. Campbell, K. Kim, C. Faul, and P. Mundel (2007)
PNAS 104, 10134-10139
   Abstract »    Full Text »    PDF »
CD2AP/CIN85 Balance Determines Receptor Tyrosine Kinase Signaling Response in Podocytes.
I. Tossidou, C. Kardinal, I. Peters, W. Kriz, A. Shaw, I. Dikic, S. Tkachuk, I. Dumler, H. Haller, and M. Schiffer (2007)
J. Biol. Chem. 282, 7457-7464
   Abstract »    Full Text »    PDF »
Expression and Subcellular Distribution of Novel Glomerulus-Associated Proteins Dendrin, Ehd3, Sh2d4a, Plekhh2, and 2310066E14Rik.
J. Patrakka, Z. Xiao, M. Nukui, M. Takemoto, L. He, A. Oddsson, L. Perisic, A. Kaukinen, C. A.-K. Szigyarto, M. Uhlen, et al. (2007)
J. Am. Soc. Nephrol. 18, 689-697
   Abstract »    Full Text »    PDF »
Active Focal Segmental Glomerulosclerosis Is Associated with Massive Oxidation of Plasma Albumin.
L. Musante, G. Candiano, A. Petretto, M. Bruschi, N. Dimasi, G. Caridi, B. Pavone, P. Del Boccio, M. Galliano, A. Urbani, et al. (2007)
J. Am. Soc. Nephrol. 18, 799-810
   Abstract »    Full Text »    PDF »
{alpha}-Actinin-4 Is Required for Normal Podocyte Adhesion.
S. V. Dandapani, H. Sugimoto, B. D. Matthews, R. J. Kolb, S. Sinha, R. E. Gerszten, J. Zhou, D. E. Ingber, R. Kalluri, and M. R. Pollak (2007)
J. Biol. Chem. 282, 467-477
   Abstract »    Full Text »    PDF »
Inaugural Article: Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels.
T. B. Huber, B. Schermer, R. U. Muller, M. Hohne, M. Bartram, A. Calixto, H. Hagmann, C. Reinhardt, F. Koos, K. Kunzelmann, et al. (2006)
PNAS 103, 17079-17086
   Abstract »    Full Text »    PDF »
Immuotactoid Glomerulopathy (Fibrillary Glomerulonephritis).
S. M. Korbet, M. M. Schwartz, and E. J. Lewis (2006)
Clin. J. Am. Soc. Nephrol. 1, 1351-1356
   Full Text »    PDF »
Repetitive Fragmentation Products of Albumin and {alpha}1-Antitrypsin in Glomerular Diseases Associated with Nephrotic Syndrome.
G. Candiano, L. Musante, M. Bruschi, A. Petretto, L. Santucci, P. D. Boccio, B. Pavone, F. Perfumo, A. Urbani, F. Scolari, et al. (2006)
J. Am. Soc. Nephrol. 17, 3139-3148
   Abstract »    Full Text »    PDF »
Identification of {alpha}-Enolase as an Autoantigen in Lung Cancer: Its Overexpression Is Associated with Clinical Outcomes..
G.-C. Chang, K.-J. Liu, C.-L. Hsieh, T.-S. Hu, S. Charoenfuprasert, H.-K. Liu, K.-T. Luh, L.-H. Hsu, C.-W. Wu, C.-C. Ting, et al. (2006)
Clin. Cancer Res. 12, 5746-5754
   Abstract »    Full Text »    PDF »
Synaptic Vesicle Protein 2B Is Expressed in Podocyte, and Its Expression Is Altered in Proteinuric Glomeruli.
N. Miyauchi, A. Saito, T. Karasawa, Y. Harita, K. Suzuki, H. Koike, G. D. Han, F. Shimizu, and H. Kawachi (2006)
J. Am. Soc. Nephrol. 17, 2748-2759
   Abstract »    Full Text »    PDF »
beta-Arrestin2 mediates nephrin endocytosis and impairs slit diaphragm integrity.
I. Quack, L. C. Rump, P. Gerke, I. Walther, T. Vinke, O. Vonend, T. Grunwald, and L. Sellin (2006)
PNAS 103, 14110-14115
   Abstract »    Full Text »    PDF »
Pierson Syndrome: A Novel Cause of Congenital Nephrotic Syndrome.
R. VanDeVoorde, D. Witte, J. Kogan, and J. Goebel (2006)
Pediatrics 118, e501-e505
   Abstract »    Full Text »    PDF »
Identification of a Novel Inhibitory Actin-capping Protein Binding Motif in CD2-associated Protein.
S. Bruck, T. B. Huber, R. J. Ingham, K. Kim, H. Niederstrasser, P. M. Allen, T. Pawson, J. A. Cooper, and A. S. Shaw (2006)
J. Biol. Chem. 281, 19196-19203
   Abstract »    Full Text »    PDF »
Differential Interactions between Transforming Growth Factor-beta3/TbetaR1, TAB1, and CD2AP Disrupt Blood-Testis Barrier and Sertoli-Germ Cell Adhesion.
W. Xia, D. D. Mruk, W. M. Lee, and C. Y. Cheng (2006)
J. Biol. Chem. 281, 16799-16813
   Abstract »    Full Text »    PDF »
IGF-Binding Protein-3 Modulates TGF-beta/BMP-Signaling in Glomerular Podocytes.
I. Peters, I. Tossidou, J. Achenbach, R. Woroniecki, M. Mengel, J.-K. Park, M. Paschy, K. de Groot, H. Haller, and M. Schiffer (2006)
J. Am. Soc. Nephrol. 17, 1644-1656
   Abstract »    Full Text »    PDF »
Diversities of Podocyte Molecular Changes Induced by Different Antiproteinuria Drugs..
Y. Xing, J. Ding, Q. Fan, and N. Guan (2006)
Experimental Biology and Medicine 231, 585-593
   Abstract »    Full Text »    PDF »
Hereditary proteinuria syndromes and mechanisms of proteinuria..
K. Tryggvason, J. Patrakka, and J. Wartiovaara (2006)
N. Engl. J. Med. 354, 1387-1401
   Full Text »    PDF »
Podocyte Cell-Specific Expression of Doxycycline Inducible Cre Recombinase in Mice.
J. Juhila, R. Roozendaal, M. Lassila, S. J. Verbeek, and H. Holthofer (2006)
J. Am. Soc. Nephrol. 17, 648-654
   Abstract »    Full Text »    PDF »
IFN-Inducible Protein-10 Plays a Pivotal Role in Maintaining Slit-Diaphragm Function by Regulating Podocyte Cell-Cycle Balance.
G. D. Han, K. Suzuki, H. Koike, K. Suzuki, H. Yoneyama, S. Narumi, F. Shimizu, and H. Kawachi (2006)
J. Am. Soc. Nephrol. 17, 442-453
   Abstract »    Full Text »    PDF »
Type IV Collagen Induces Podocytic Features in Bone Marrow Stromal Stem Cells In Vitro.
J. Perry, S. Tam, K. Zheng, Y. Sado, H. Dobson, B. Jefferson, R. Jacobs, and P. S. Thorner (2006)
J. Am. Soc. Nephrol. 17, 66-76
   Abstract »    Full Text »    PDF »
Activation of G{alpha}q-Coupled Signaling Pathways in Glomerular Podocytes Promotes Renal Injury.
L. Wang, T. A. Fields, K. Pazmino, Q. Dai, J. L. Burchette, D. N. Howell, T. M. Coffman, and R. F. Spurney (2005)
J. Am. Soc. Nephrol. 16, 3611-3622
   Abstract »    Full Text »    PDF »
The Human Glomerular Podocyte Is a Novel Target for Insulin Action.
R. J.M. Coward, G. I. Welsh, J. Yang, C. Tasman, R. Lennon, A. Koziell, S. Satchell, G. D. Holman, D. Kerjaschki, J. M. Tavare, et al. (2005)
Diabetes 54, 3095-3102
   Abstract »    Full Text »    PDF »
Association of CD2AP with dynamic actin on vesicles in podocytes.
T. Welsch, N. Endlich, G. Gokce, E. Doroshenko, J. C. Simpson, W. Kriz, A. S. Shaw, and K. Endlich (2005)
Am J Physiol Renal Physiol 289, F1134-F1143
   Abstract »    Full Text »    PDF »
Slit or pore? A mutation of the ion channel TRPC6 causes FSGS.
G. Walz (2005)
Nephrol. Dial. Transplant. 20, 1777-1779
   Full Text »    PDF »
CD2-associated Protein (CD2AP) Expression in Podocytes Rescues Lethality of CD2AP Deficiency.
J. A. Grunkemeyer, C. Kwoh, T. B. Huber, and A. S. Shaw (2005)
J. Biol. Chem. 280, 29677-29681
   Abstract »    Full Text »    PDF »
Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and {alpha}-actinin are components of the nephrin multiprotein complex.
S. Lehtonen, J. J. Ryan, K. Kudlicka, N. Iino, H. Zhou, and M. G. Farquhar (2005)
PNAS 102, 9814-9819
   Abstract »    Full Text »    PDF »
Clues to CD2-associated Protein Involvement in Cytokinesis.
P. Monzo, N. C. Gauthier, F. Keslair, A. Loubat, C. M. Field, Y. Le Marchand-Brustel, and M. Cormont (2005)
Mol. Biol. Cell 16, 2891-2902
   Abstract »    Full Text »    PDF »
In Response to Protein Load Podocytes Reorganize Cytoskeleton and Modulate Endothelin-1 Gene: Implication for Permselective Dysfunction of Chronic Nephropathies.
M. Morigi, S. Buelli, S. Angioletti, C. Zanchi, L. Longaretti, C. Zoja, M. Galbusera, S. Gastoldi, P. Mundel, G. Remuzzi, et al. (2005)
Am. J. Pathol. 166, 1309-1320
   Abstract »    Full Text »    PDF »
How Does the Kidney Filter Plasma?.
K. Tryggvason and J. Wartiovaara (2005)
Physiology 20, 96-101
   Abstract »    Full Text »    PDF »
Genetic Engineering of Glomerular Sclerosis in the Mouse via Control of Onset and Severity of Podocyte-Specific Injury.
T. Matsusaka, J. Xin, S. Niwa, K. Kobayashi, A. Akatsuka, H. Hashizume, Q.-c. Wang, I. Pastan, A. B. Fogo, and I. Ichikawa (2005)
J. Am. Soc. Nephrol. 16, 1013-1023
   Abstract »    Full Text »    PDF »
Nephrotic Plasma Alters Slit Diaphragm-Dependent Signaling and Translocates Nephrin, Podocin, and CD2 Associated Protein in Cultured Human Podocytes.
R. J.M. Coward, R. R. Foster, D. Patton, L. Ni, R. Lennon, D. O. Bates, S. J. Harper, P. W. Mathieson, and M. A. Saleem (2005)
J. Am. Soc. Nephrol. 16, 629-637
   Abstract »    Full Text »    PDF »
Vascular endothelial growth factor and nephrin interact and reduce apoptosis in human podocytes.
R. R. Foster, M. A. Saleem, P. W. Mathieson, D. O. Bates, and S. J. Harper (2005)
Am J Physiol Renal Physiol 288, F48-F57
   Abstract »    Full Text »    PDF »
Ultrastructural study on nephrin expression in experimental puromycin aminonucleoside nephrosis.
Y. K. Lee, T. Kwon, D. J. Kim, W. Huh, Y.-G. Kim, H.-Y. Oh, and H. Kawachi (2004)
Nephrol. Dial. Transplant. 19, 2981-2986
   Abstract »    Full Text »    PDF »
The Wt1+/R394W Mouse Displays Glomerulosclerosis and Early-Onset Renal Failure Characteristic of Human Denys-Drash Syndrome.
F. Gao, S. Maiti, G. Sun, N. G. Ordonez, M. Udtha, J. M. Deng, R. R. Behringer, and V. Huff (2004)
Mol. Cell. Biol. 24, 9899-9910
   Abstract »    Full Text »    PDF »
Effect of the Knockdown of Podocin mRNA on Nephrin and {alpha}-Actinin in Mouse Podocyte.
Q. Fan, J. Ding, J. Zhang, N. Guan, and J. Deng (2004)
Experimental Biology and Medicine 229, 964-970
   Abstract »    Full Text »    PDF »
Podocytes Are Firmly Attached to Glomerular Basement Membrane in Kidneys with Heavy Proteinuria.
A.-T. Lahdenkari, K. Lounatmaa, J. Patrakka, C. Holmberg, J. Wartiovaara, M. Kestila, O. Koskimies, and H. Jalanko (2004)
J. Am. Soc. Nephrol. 15, 2611-2618
   Abstract »    Full Text »    PDF »
Nephrin Forms a Complex with Adherens Junction Proteins and CASK in Podocytes and in Madin-Darby Canine Kidney Cells Expressing Nephrin.
S. Lehtonen, E. Lehtonen, K. Kudlicka, H. Holthofer, and M. G. Farquhar (2004)
Am. J. Pathol. 165, 923-936
   Abstract »    Full Text »    PDF »
A Novel Role for the Adaptor Molecule CD2-associated Protein in Transforming Growth Factor-{beta}-induced Apoptosis.
M. Schiffer, P. Mundel, A. S. Shaw, and E. P. Bottinger (2004)
J. Biol. Chem. 279, 37004-37012
   Abstract »    Full Text »    PDF »
Podocyte Migration during Nephrotic Syndrome Requires a Coordinated Interplay between Cathepsin L and {alpha}3 Integrin.
J. Reiser, J. Oh, I. Shirato, K. Asanuma, A. Hug, T. M. Mundel, K. Honey, K. Ishidoh, E. Kominami, J. A. Kreidberg, et al. (2004)
J. Biol. Chem. 279, 34827-34832
   Abstract »    Full Text »    PDF »
Signaling at the Slit Diaphragm.
T. Benzing (2004)
J. Am. Soc. Nephrol. 15, 1382-1391
   Full Text »    PDF »
A WT1 Co-regulator Controls Podocyte Phenotype by Shuttling between Adhesion Structures and Nucleus.
M. B. Srichai, M. Konieczkowski, A. Padiyar, D. J. Konieczkowski, A. Mukherjee, P. S. Hayden, S. Kamat, M. A. El-Meanawy, S. Khan, P. Mundel, et al. (2004)
J. Biol. Chem. 279, 14398-14408
   Abstract »    Full Text »    PDF »
Early Glomerular Filtration Defect and Severe Renal Disease in Podocin-Deficient Mice.
S. Roselli, L. Heidet, M. Sich, A. Henger, M. Kretzler, M.-C. Gubler, and C. Antignac (2004)
Mol. Cell. Biol. 24, 550-560
   Abstract »    Full Text »    PDF »
Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains.
T. B. Huber, M. Simons, B. Hartleben, L. Sernetz, M. Schmidts, E. Gundlach, M. A. Saleem, G. Walz, and T. Benzing (2003)
Hum. Mol. Genet. 12, 3397-3405
   Abstract »    Full Text »    PDF »
IFN-Inducible Protein-10 Has a Differential Role in Podocyte during Thy 1.1 Glomerulonephritis.
G. D. Han, H. Koike, T. Nakatsue, K. Suzuki, H. Yoneyama, S. Narumi, N. Kobayashi, P. Mundel, F. Shimizu, and H. Kawachi (2003)
J. Am. Soc. Nephrol. 14, 3111-3126
   Abstract »    Full Text »    PDF »
Nephrin Promotes Cell-Cell Adhesion through Homophilic Interactions.
J. Khoshnoodi, K. Sigmundsson, L.-G. Ofverstedt, U. Skoglund, B. Obrink, J. Wartiovaara, and K. Tryggvason (2003)
Am. J. Pathol. 163, 2337-2346
   Abstract »    Full Text »
The Immunological Synapse Balances T Cell Receptor Signaling and Degradation.
K.-H. Lee, A. R. Dinner, C. Tu, G. Campi, S. Raychaudhuri, R. Varma, T. N. Sims, W. R. Burack, H. Wu, J. Wang, et al. (2003)
Science 302, 1218-1222
   Abstract »    Full Text »    PDF »
Expression of Podocyte-Associated Molecules in Acquired Human Kidney Diseases.
K. Koop, M. Eikmans, H. J. Baelde, H. Kawachi, E. de Heer, L. C. Paul, and J. A. Bruijn (2003)
J. Am. Soc. Nephrol. 14, 2063-2071
   Abstract »    Full Text »    PDF »
Nephrin and CD2AP Associate with Phosphoinositide 3-OH Kinase and Stimulate AKT-Dependent Signaling.
T. B. Huber, B. Hartleben, J. Kim, M. Schmidts, B. Schermer, A. Keil, L. Egger, R. L. Lecha, C. Borner, H. Pavenstadt, et al. (2003)
Mol. Cell. Biol. 23, 4917-4928
   Abstract »    Full Text »    PDF »
A Novel Protein, Densin, Expressed by Glomerular Podocytes.
H. Ahola, E. Heikkila, E. Astrom, M. Inagaki, I. Izawa, H. Pavenstadt, D. Kerjaschki, and H. Holthofer (2003)
J. Am. Soc. Nephrol. 14, 1731-1737
   Abstract »    Full Text »    PDF »
In Vivo Expression of Putative LMX1B Targets in Nail-Patella Syndrome Kidneys.
L. Heidet, E. M. H. F. Bongers, M. Sich, S.-Y. Zhang, C. Loirat, A. Meyrier, M. Broyer, G. Landthaler, B. Faller, Y. Sado, et al. (2003)
Am. J. Pathol. 163, 145-155
   Abstract »    Full Text »    PDF »
Linkage Analysis of Candidate Loci for End-Stage Renal Disease due to Diabetic Nephropathy.
S. K. Iyengar, K. A. Fox, M. Schachere, F. Manzoor, M. E. Slaughter, A. M. Covic, S. M. Orloff, P. S. Hayden, J. M. Olson, J. R. Schelling, et al. (2003)
J. Am. Soc. Nephrol. 14, S195-201
   Abstract »    Full Text »    PDF »
Linking the T Cell Surface Protein CD2 to the Actin-capping Protein CAPZ via CMS and CIN85.
N. J. Hutchings, N. Clarkson, R. Chalkley, A. N. Barclay, and M. H. Brown (2003)
J. Biol. Chem. 278, 22396-22403
   Abstract »    Full Text »    PDF »
Cell Biological and Biochemical Characterization of Drebrin Complexes in Mesangial Cells and Podocytes of Renal Glomeruli.
W. K. Peitsch, I. Hofmann, N. Endlich, S. Pratzel, C. Kuhn, H. Spring, H.-J. Grone, W. Kriz, and W. W. Franke (2003)
J. Am. Soc. Nephrol. 14, 1452-1463
   Abstract »    Full Text »    PDF »
Podocyte Differentiation and Hereditary Proteinuria/Nephrotic Syndromes.
M.-C. Gubler (2003)
J. Am. Soc. Nephrol. 14, S22-26
   Abstract »    Full Text »    PDF »
Fyn Binds to and Phosphorylates the Kidney Slit Diaphragm Component Nephrin.
R. Verma, B. Wharram, I. Kovari, R. Kunkel, D. Nihalani, K. K. Wary, R. C. Wiggins, P. Killen, and L. B. Holzman (2003)
J. Biol. Chem. 278, 20716-20723
   Abstract »    Full Text »    PDF »
CD2-Associated Protein Haploinsufficiency Is Linked to Glomerular Disease Susceptibility.
J. M. Kim, H. Wu, G. Green, C. A. Winkler, J. B. Kopp, J. H. Miner, E. R. Unanue, and A. S. Shaw (2003)
Science 300, 1298-1300
   Abstract »    Full Text »    PDF »
Nephrin and Neph1 Co-localize at the Podocyte Foot Process Intercellular Junction and Form cis Hetero-oligomers.
G.-M. Barletta, I. A. Kovari, R. K. Verma, D. Kerjaschki, and L. B. Holzman (2003)
J. Biol. Chem. 278, 19266-19271
   Abstract »    Full Text »    PDF »
Angiogenic Protein Cyr61 is Expressed by Podocytes in Anti-Thy-1 Glomerulonephritis.
K. Sawai, K. Mori, M. Mukoyama, A. Sugawara, T. Suganami, M. Koshikawa, K. Yahata, H. Makino, T. Nagae, Y. Fujinaga, et al. (2003)
J. Am. Soc. Nephrol. 14, 1154-1163
   Abstract »    Full Text »    PDF »
Broadening the Spectrum of Diseases Related to Podocin Mutations.
G. Caridi, R. Bertelli, M. Di Duca, M. Dagnino, F. Emma, A. Onetti Muda, F. Scolari, N. Miglietti, G. Mazzucco, L. Murer, et al. (2003)
J. Am. Soc. Nephrol. 14, 1278-1286
   Abstract »    Full Text »    PDF »
Neutralization of Circulating Vascular Endothelial Growth Factor (VEGF) by Anti-VEGF Antibodies and Soluble VEGF Receptor 1 (sFlt-1) Induces Proteinuria.
H. Sugimoto, Y. Hamano, D. Charytan, D. Cosgrove, M. Kieran, A. Sudhakar, and R. Kalluri (2003)
J. Biol. Chem. 278, 12605-12608
   Abstract »    Full Text »    PDF »
The Carboxyl Terminus of Neph Family Members Binds to the PDZ Domain Protein Zonula Occludens-1.
T. B. Huber, M. Schmidts, P. Gerke, B. Schermer, A. Zahn, B. Hartleben, L. Sellin, G. Walz, and T. Benzing (2003)
J. Biol. Chem. 278, 13417-13421
   Abstract »    Full Text »    PDF »
CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities.
E. V. Tibaldi and E. L. Reinherz (2003)
Int. Immunol. 15, 313-329
   Abstract »    Full Text »    PDF »
Podocyte Differentiation and Glomerulogenesis.
J. A. Kreidberg (2003)
J. Am. Soc. Nephrol. 14, 806-814
   Full Text »    PDF »
Alternatively Used Promoters and Distinct Elements Direct Tissue-Specific Expression of Nephrin.
O. Beltcheva, S. Kontusaari, S. Fetissov, H. Putaala, P. Kilpelainen, T. Hokfelt, and K. Tryggvason (2003)
J. Am. Soc. Nephrol. 14, 352-358
   Abstract »    Full Text »    PDF »
TGF-beta signal transduction and mesangial cell fibrogenesis.
H. W. Schnaper, T. Hayashida, S. C. Hubchak, and A.-C. Poncelet (2003)
Am J Physiol Renal Physiol 284, F243-F252
   Abstract »    Full Text »    PDF »
Altered ultrastructural distribution of nephrin in minimal change nephrotic syndrome.
A. Wernerson, F. Duner, E. Pettersson, S. M. Widholm, U. Berg, V. Ruotsalainen, K. Tryggvason, K. Hultenby, and M. Soderberg (2003)
Nephrol. Dial. Transplant. 18, 70-76
   Abstract »    Full Text »    PDF »
Cloning of Rat Homologue of Podocin: Expression in Proteinuric States and in Developing Glomeruli.
H. Kawachi, H. Koike, H. Kurihara, T. Sakai, and F. Shimizu (2003)
J. Am. Soc. Nephrol. 14, 46-56
   Abstract »    Full Text »    PDF »
Cell Biology of the Glomerular Podocyte.
H. Pavenstadt, W. Kriz, and M. Kretzler (2003)
Physiol Rev 83, 253-307
   Abstract »    Full Text »    PDF »
Enhanced expression of the immunoregulator, p43-placental isoferritin, in Down's syndrome placentae and fetal kidneys.
R. Maymon, E. Jauniaux, and C. Moroz (2002)
Mol. Hum. Reprod. 8, 1125-1128
   Abstract »    Full Text »    PDF »
Podocyte Biology and Response to Injury.
P. Mundel and S. J. Shankland (2002)
J. Am. Soc. Nephrol. 13, 3005-3015
   Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)