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Science 17 September 1999:
Vol. 285. no. 5435, pp. 1870 - 1874
DOI: 10.1126/science.285.5435.1870
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Review

Long-Term Potentiation--A Decade of Progress?

Robert C. Malenka, 1 and Roger A. Nicoll 2

Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.

1 Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.
2 Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, CA 94143, USA. E-mail: malenka{at}stanford.edu and nicoll{at}phy.ucsf.edu

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Requirement of Akt to Mediate Long-Term Synaptic Depression in Drosophila.
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J. Neurosci. 26, 4004-4014
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Delayed amnesic syndrome after riluzole autointoxication in Huntington disease.
C. A. Haaxma, H.P.H. Kremer, and B. P.C. van de Warrenburg (2006)
Neurology 66, 1123-1124
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A biophysically based neural model of matching law behavior: melioration by stochastic synapses..
A. Soltani and X.-J. Wang (2006)
J. Neurosci. 26, 3731-3744
   Abstract »    Full Text »    PDF »
Synergistic control of protein kinase Cgamma activity by ionotropic and metabotropic glutamate receptor inputs in hippocampal neurons..
F. Codazzi, A. Di Cesare, N. Chiulli, A. Albanese, T. Meyer, D. Zacchetti, and F. Grohovaz (2006)
J. Neurosci. 26, 3404-3411
   Abstract »    Full Text »    PDF »
Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase Cgamma signaling..
A. Gartner, D. G. Polnau, V. Staiger, C. Sciarretta, L. Minichiello, H. Thoenen, T. Bonhoeffer, and M. Korte (2006)
J. Neurosci. 26, 3496-3504
   Abstract »    Full Text »    PDF »
Coincidence detection of synaptic inputs is facilitated at the distal dendrites after long-term potentiation induction..
N.-l. Xu, C.-q. Ye, M.-m. Poo, and X.-h. Zhang (2006)
J. Neurosci. 26, 3002-3009
   Abstract »    Full Text »    PDF »
Auxiliary Subunits Assist AMPA-Type Glutamate Receptors..
R. A. Nicoll, S. Tomita, and D. S. Bredt (2006)
Science 311, 1253-1256
   Abstract »    Full Text »    PDF »
What Is the Functional Significance of Chronic Stress-Induced CA3 Dendritic Retraction Within the Hippocampus?.
C. D. Conrad (2006)
Behav Cogn Neurosci Rev 5, 41-60
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