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Science 10 September 1999:
Vol. 285. no. 5434, pp. 1745 - 1747
DOI: 10.1126/science.285.5434.1745
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Reports

Clonal Interference and the Evolution of RNA Viruses

Rosario Miralles, 1 Philip J. Gerrish, 2* Andrés Moya, 1 Santiago F. Elena 1dagger

In asexual populations, beneficial mutations that occur in different lineages compete with one another. This phenomenon, known as clonal interference, ensures that those beneficial mutations that do achieve fixation are of large effect. Clonal interference also increases the time between fixations, thereby slowing the adaptation of asexual populations. The effects of clonal interference were measured in the asexual RNA virus vesicular stomatitis virus; rates and average effects of beneficial mutations were quantified.

1 Institut Cavanilles de Biodiversitat i Biología Evolutiva and Departament de Genètica, Universitat de València, Apartado 22085, 46071 València, Spain.
2 Center for Disease Control and Prevention, Atlanta, GA 30333, USA.
*   Present address: Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

dagger    To whom correspondence should be addressed. E-mail: santiago.elena{at}uv.es

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