Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 August 1999:
Vol. 285. no. 5432, pp. 1411 - 1414
DOI: 10.1126/science.285.5432.1411
Prev | Table of Contents

Reports

Long-Term Depression in Hippocampal Interneurons: Joint Requirement for Pre- and Postsynaptic Events

Fernanda Laezza, 12 James J. Doherty, 2 Raymond Dingledine 2*

Long-term depression (LTD) is a well-known form of synaptic plasticity of principal neurons in the mammalian brain. Whether such changes occur in interneurons is still controversial. CA3 hippocampal interneurons expressing Ca2+-permeable AMPA receptors exhibited LTD after tetanic stimulation of CA3 excitatory inputs. LTD was independent of NMDA receptors and required both Ca2+ influx through postsynaptic AMPA receptors and activation of presynaptic mGluR7-like receptors. These results point to the capability of interneurons to undergo plastic changes of synaptic strength through joint activation of pre- and postsynaptic glutamate receptors.

1 Neuroscience Graduate Program,
2 Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA.
*   To whom correspondance should be addressed. E-mail: rdingledine{at}pharm.emory.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Calcium-Permeable Presynaptic Kainate Receptors Involved in Excitatory Short-Term Facilitation Onto Somatostatin Interneurons During Natural Stimulus Patterns.
H. Y. Sun, A. F. Bartley, and L. E. Dobrunz (2009)
J Neurophysiol 101, 1043-1055
   Abstract »    Full Text »    PDF »
Role of Ionotropic Glutamate Receptors in Long-Term Potentiation in Rat Hippocampal CA1 Oriens-Lacunosum Moleculare Interneurons.
I. Oren, W. Nissen, D. M. Kullmann, P. Somogyi, and K. P. Lamsa (2009)
J. Neurosci. 29, 939-950
   Abstract »    Full Text »    PDF »
Bidirectional Hebbian Plasticity at Hippocampal Mossy Fiber Synapses on CA3 Interneurons.
E. J. Galvan, E. Calixto, and G. Barrionuevo (2008)
J. Neurosci. 28, 14042-14055
   Abstract »    Full Text »    PDF »
Knock-In Mice Lacking the PDZ-Ligand Motif of mGluR7a Show Impaired PKC-Dependent Autoinhibition of Glutamate Release, Spatial Working Memory Deficits, and Increased Susceptibility to Pentylenetetrazol.
C.-S. Zhang, F. Bertaso, V. Eulenburg, M. Lerner-Natoli, G. A. Herin, L. Bauer, J. Bockaert, L. Fagni, H. Betz, and A. Scheschonka (2008)
J. Neurosci. 28, 8604-8614
   Abstract »    Full Text »    PDF »
Spike-Timing-Dependent Plasticity of Neocortical Excitatory Synapses on Inhibitory Interneurons Depends on Target Cell Type.
J.-t. Lu, C.-y. Li, J.-P. Zhao, M.-m. Poo, and X.-h. Zhang (2007)
J. Neurosci. 27, 9711-9720
   Abstract »    Full Text »    PDF »
Light triggers expression of philanthotoxin-insensitive Ca2+-permeable AMPA receptors in the developing rat retina.
I. K. Osswald, A. Galan, and D. Bowie (2007)
J. Physiol. 582, 95-111
   Abstract »    Full Text »    PDF »
Anti-Hebbian Long-Term Potentiation in the Hippocampal Feedback Inhibitory Circuit.
K. P. Lamsa, J. H. Heeroma, P. Somogyi, D. A. Rusakov, and D. M. Kullmann (2007)
Science 315, 1262-1266
   Abstract »    Full Text »    PDF »
Presynaptic kainate receptor activation is a novel mechanism for target cell-specific short-term facilitation at schaffer collateral synapses..
H. Y. Sun and L. E. Dobrunz (2006)
J. Neurosci. 26, 10796-10807
   Abstract »    Full Text »    PDF »
mGluR1/5 subtype-specific calcium signalling and induction of long-term potentiation in rat hippocampal oriens/alveus interneurones.
L. Topolnik, M. Azzi, F. Morin, A. Kougioumoutzakis, and J.-C. Lacaille (2006)
J. Physiol. 575, 115-131
   Abstract »    Full Text »    PDF »
Evidence for Ca2+-permeable AMPA receptors in the olfactory bulb.
L. J. Blakemore, M. Resasco, M. A. Mercado, and P. Q. Trombley (2006)
Am J Physiol Cell Physiol 290, C925-C935
   Abstract »    Full Text »    PDF »
Mechanisms of target-cell specific short-term plasticity at Schaffer collateral synapses onto interneurones versus pyramidal cells in juvenile rats.
H. Y. Sun, S. A Lyons, and L. E Dobrunz (2005)
J. Physiol. 568, 815-840
   Abstract »    Full Text »    PDF »
Differential Regulation of Metabotropic Glutamate Receptor- and AMPA Receptor-Mediated Dendritic Ca2+ Signals by Presynaptic and Postsynaptic Activity in Hippocampal Interneurons.
L. Topolnik, P. Congar, and J.-C. Lacaille (2005)
J. Neurosci. 25, 990-1001
   Abstract »    Full Text »    PDF »
Voltage-Controlled Plasticity at GluR2-Deficient Synapses Onto Hippocampal Interneurons.
F. Laezza and R. Dingledine (2004)
J Neurophysiol 92, 3575-3581
   Abstract »    Full Text »    PDF »
Medial Perforant Path Inhibition Mediated by mGluR7 Is Reduced After Status Epilepticus.
K. J. Bough, D. D. Mott, and R. J. Dingledine (2004)
J Neurophysiol 92, 1549-1557
   Abstract »    Full Text »    PDF »
Two Loci of Expression for Long-Term Depression at Hippocampal Mossy Fiber-Interneuron Synapses.
S. Lei and C. J. McBain (2004)
J. Neurosci. 24, 2112-2121
   Abstract »    Full Text »    PDF »
Synapse-specific mGluR1-dependent long-term potentiation in interneurones regulates mouse hippocampal inhibition.
V. Lapointe, F. Morin, S. Ratte, A. Croce, F. Conquet, and J.-C. Lacaille (2004)
J. Physiol. 555, 125-135
   Abstract »    Full Text »    PDF »
Activation of Metabotropic Glutamate 5 and NMDA Receptors Underlies the Induction of Persistent Bursting and Associated Long-Lasting Changes in CA3 Recurrent Connections.
R. Stoop, F. Conquet, B. Zuber, L. L. Voronin, and E. Pralong (2003)
J. Neurosci. 23, 5634-5644
   Abstract »    Full Text »    PDF »
Reduction of Excitatory Postsynaptic Responses by Persistently Active Metabotropic Glutamate Receptors in the Hippocampus.
A. Losonczy, P. Somogyi, and Z. Nusser (2003)
J Neurophysiol 89, 1910-1919
   Abstract »    Full Text »    PDF »
Chronic NMDA Receptor Blockade From Birth Delays the Maturation of NMDA Currents, but Does Not Affect AMPA/Kainate Currents.
M. T. Colonnese, J. Shi, and M. Constantine-Paton (2003)
J Neurophysiol 89, 57-68
   Abstract »    Full Text »    PDF »
Enrichment of mGluR7a in the Presynaptic Active Zones of GABAergic and Non-GABAergic Terminals on Interneurons in the Rat Somatosensory Cortex.
Y. Dalezios, R. Lujan, R. Shigemoto, J. D. B. Roberts, and P. Somogyi (2002)
Cereb Cortex 12, 961-974
   Abstract »    Full Text »    PDF »
PTP and LTP at a hippocampal mossy fiber-interneuron synapse.
H. Alle, P. Jonas, and J. R. P. Geiger (2001)
PNAS 98, 14708-14713
   Abstract »    Full Text »    PDF »
Self-Organized Synaptic Plasticity Contributes to the Shaping of gamma and beta Oscillations In Vitro.
A. Bibbig, H. J. Faulkner, M. A. Whittington, and R. D. Traub (2001)
J. Neurosci. 21, 9053-9067
   Abstract »    Full Text »    PDF »
Decreased Glutamate Receptor 2 Expression and Enhanced Epileptogenesis in Immature Rat Hippocampus after Perinatal Hypoxia-Induced Seizures.
R. M. Sanchez, S. Koh, C. Rio, C. Wang, E. D. Lamperti, D. Sharma, G. Corfas, and F. E. Jensen (2001)
J. Neurosci. 21, 8154-8163
   Abstract »    Full Text »    PDF »
Developmental Depression of Glutamate Neurotransmission by Chronic Low-Level Activation of NMDA Receptors.
J. Shi, S. M. Aamodt, M. Townsend, and M. Constantine-Paton (2001)
J. Neurosci. 21, 6233-6244
   Abstract »    Full Text »    PDF »
A hebbian form of long-term potentiation dependent on mGluR1a in hippocampal inhibitory interneurons.
Y. Perez, F. Morin, and J.-C. Lacaille (2001)
PNAS
   Abstract »    Full Text »    PDF »
Long-term plasticity in interneurons of the dentate gyrus.
S. T. Ross and I. Soltesz (2001)
PNAS
   Abstract »    Full Text »    PDF »
Medium Afterhyperpolarization and Firing Pattern Modulation in Interneurons of Stratum Radiatum in the CA3 Hippocampal Region.
N. Savic, P. Pedarzani, and M. Sciancalepore (2001)
J Neurophysiol 85, 1986-1997
   Abstract »    Full Text »    PDF »
Electrophysiological Characterization of "Giant" Cells in Stratum Radiatum of the CA3 Hippocampal Region.
N. Savic and M. Sciancalepore (2001)
J Neurophysiol 85, 1998-2007
   Abstract »    Full Text »    PDF »
LTD Induction in Adult Visual Cortex: Role of Stimulus Timing and Inhibition.
S. P. Perrett, S. M. Dudek, D. Eagleman, P. R. Montague, and M. J. Friedlander (2001)
J. Neurosci. 21, 2308-2319
   Abstract »    Full Text »    PDF »
Reduced Excitatory Drive onto Interneurons in the Dentate Gyrus after Status Epilepticus.
J. Doherty and R. Dingledine (2001)
J. Neurosci. 21, 2048-2057
   Abstract »    Full Text »    PDF »
Differential Cellular and Subcellular Localization of AMPA Receptor-Binding Protein and Glutamate Receptor-Interacting Protein.
A. Burette, L. Khatri, M. Wyszynski, M. Sheng, E. B. Ziff, and R. J. Weinberg (2001)
J. Neurosci. 21, 495-503
   Abstract »    Full Text »    PDF »
Differential Mechanisms of Transmission at Three Types of Mossy Fiber Synapse.
K. Toth, G. Suares, J. J. Lawrence, E. Philips-Tansey, and C. J. McBain (2000)
J. Neurosci. 20, 8279-8289
   Abstract »    Full Text »    PDF »
Modulation of Long-Term Depression by Dopamine in the Mesolimbic System.
M. J. Thomas, R. C. Malenka, and A. Bonci (2000)
J. Neurosci. 20, 5581-5586
   Abstract »    Full Text »    PDF »
Long-term plasticity in interneurons of the dentate gyrus.
S. T. Ross and I. Soltesz (2001)
PNAS 98, 8874-8879
   Abstract »    Full Text »    PDF »
A hebbian form of long-term potentiation dependent on mGluR1a in hippocampal inhibitory interneurons.
Y. Perez, F. Morin, and J.-C. Lacaille (2001)
PNAS 98, 9401-9406
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)