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Science 13 August 1999:
Vol. 285. no. 5430, pp. 1028 - 1033
DOI: 10.1126/science.285.5430.1028
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Review

Integrin Signaling

Filippo G. Giancotti, 1 Erkki Ruoslahti 2

Cells reside in a protein network, the extracellular matrix (ECM), which they secrete and mold into the intercellular space. The ECM exerts profound control over cells. The effects of the matrix are primarily mediated by integrins, a family of cell surface receptors that attach cells to the matrix and mediate mechanical and chemical signals from it. These signals regulate the activities of cytoplasmic kinases, growth factor receptors, and ion channels and control the organization of the intracellular actin cytoskeleton. Many integrin signals converge on cell cycle regulation, directing cells to live or die, to proliferate, or to exit the cell cycle and differentiate.

1 Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. E-mail: f-giancotti{at}ski.mskcc.org
2 Cancer Research Center, The Burnham Institute, La Jolla, CA 92027, USA. E-mail: ruoslahti{at}burnham.inst.org

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CD98hc (SLC3A2) Interaction with the Integrin beta Subunit Cytoplasmic Domain Mediates Adhesive Signaling.
G. W. Prager, C. C. Feral, C. Kim, J. Han, and M. H. Ginsberg (2007)
J. Biol. Chem. 282, 24477-24484
   Abstract »    Full Text »    PDF »
Akt1 Signaling Regulates Integrin Activation, Matrix Recognition, and Fibronectin Assembly.
P. R. Somanath, E. S. Kandel, N. Hay, and T. V. Byzova (2007)
J. Biol. Chem. 282, 22964-22976
   Abstract »    Full Text »    PDF »
Lipid Rafts of Primary Endothelial Cells Are Essential for Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8-Induced Phosphatidylinositol 3-Kinase and RhoA-GTPases Critical for Microtubule Dynamics and Nuclear Delivery of Viral DNA but Dispensable for Binding and Entry.
H. Raghu, N. Sharma-Walia, M. V. Veettil, S. Sadagopan, A. Caballero, R. Sivakumar, L. Varga, V. Bottero, and B. Chandran (2007)
J. Virol. 81, 7941-7959
   Abstract »    Full Text »    PDF »
Multiple Receptor Interactions Trigger Release of Membrane and Intracellular Calcium Stores Critical for Herpes Simplex Virus Entry.
N. Cheshenko, W. Liu, L. M. Satlin, and B. C. Herold (2007)
Mol. Biol. Cell 18, 3119-3130
   Abstract »    Full Text »    PDF »
Laminin-{alpha}4 and Integrin-Linked Kinase Mutations Cause Human Cardiomyopathy Via Simultaneous Defects in Cardiomyocytes and Endothelial Cells.
R. Knoll, R. Postel, J. Wang, R. Kratzner, G. Hennecke, A. M. Vacaru, P. Vakeel, C. Schubert, K. Murthy, B. K. Rana, et al. (2007)
Circulation 116, 515-525
   Abstract »    Full Text »    PDF »
MFG-E8/Lactadherin Promotes Tumor Growth in an Angiogenesis-Dependent Transgenic Mouse Model of Multistage Carcinogenesis.
M. Neutzner, T. Lopez, X. Feng, E. S. Bergmann-Leitner, W. W. Leitner, and M. C. Udey (2007)
Cancer Res. 67, 6777-6785
   Abstract »    Full Text »    PDF »
Filamin B mutations cause chondrocyte defects in skeletal development.
J. Lu, G. Lian, R. Lenkinski, A. De Grand, R. R. Vaid, T. Bryce, M. Stasenko, A. Boskey, C. Walsh, and V. Sheen (2007)
Hum. Mol. Genet. 16, 1661-1675
   Abstract »    Full Text »    PDF »
Fibrinogen inhibits neurite outgrowth via beta3 integrin-mediated phosphorylation of the EGF receptor.
C. Schachtrup, P. Lu, L. L. Jones, J. K. Lee, J. Lu, B. D. Sachs, B. Zheng, and K. Akassoglou (2007)
PNAS 104, 11814-11819
   Abstract »    Full Text »    PDF »
Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization.
N. H. Putnam, M. Srivastava, U. Hellsten, B. Dirks, J. Chapman, A. Salamov, A. Terry, H. Shapiro, E. Lindquist, V. V. Kapitonov, et al. (2007)
Science 317, 86-94
   Abstract »    Full Text »    PDF »
The ECM protein nephronectin promotes kidney development via integrin {alpha}8{beta}1-mediated stimulation of Gdnf expression.
J. M. Linton, G. R. Martin, and L. F. Reichardt (2007)
Development 134, 2501-2509
   Abstract »    Full Text »    PDF »
Src Utilizes Cas to Block Gap Junctional Communication Mediated by Connexin43.
Y. Shen, P. R. Khusial, X. Li, H. Ichikawa, A. P. Moreno, and G. S. Goldberg (2007)
J. Biol. Chem. 282, 18914-18921
   Abstract »    Full Text »    PDF »
Double Duty for Rac1 in Epidermal Wound Healing.
C. M. DiPersio (2007)
Sci. STKE 2007, pe33
   Abstract »    Full Text »    PDF »
Fibronectin- and Vitronectin-Induced Microglial Activation and Matrix Metalloproteinase-9 Expression Is Mediated by Integrins {alpha}5beta1 and {alpha}vbeta5.
R. Milner, S. J. Crocker, S. Hung, X. Wang, R. F. Frausto, and G. J. del Zoppo (2007)
J. Immunol. 178, 8158-8167
   Abstract »    Full Text »    PDF »
Def-6, a Guanine Nucleotide Exchange Factor for Rac1, Interacts with the Skeletal Muscle Integrin Chain {alpha}7A and Influences Myoblast Differentiation.
T. Samson, C. Will, A. Knoblauch, L. Sharek, K. von der Mark, K. Burridge, and V. Wixler (2007)
J. Biol. Chem. 282, 15730-15742
   Abstract »    Full Text »    PDF »
The role of PKC and PDK1 in monocyte lineage specification by Ras.
L. Pearn, J. Fisher, A. K. Burnett, and R. L. Darley (2007)
Blood 109, 4461-4469
   Abstract »    Full Text »    PDF »
Effect of fibronectin on proteasome activity, acrosome reaction, tyrosine phosphorylation and intracellular calcium concentrations of human sperm.
E. S. Diaz, M. Kong, and P. Morales (2007)
Hum. Reprod. 22, 1420-1430
   Abstract »    Full Text »    PDF »
Formation of Cysts by Alveolar Type II Cells in Three-dimensional Culture Reveals a Novel Mechanism for Epithelial Morphogenesis.
W. Yu, X. Fang, A. Ewald, K. Wong, C. A. Hunt, Z. Werb, M. A. Matthay, and K. Mostov (2007)
Mol. Biol. Cell 18, 1693-1700
   Abstract »    Full Text »    PDF »


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