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Science 6 August 1999:
Vol. 285. no. 5429, pp. 906 - 909
DOI: 10.1126/science.285.5429.906
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Reports

Early Neocortical Regionalization in the Absence of Thalamic Innervation

Emily M. Miyashita-Lin, 1* Robert Hevner, 1* Karen Montzka Wassarman, 2 † Salvador Martinez, 3 John L. R. Rubenstein 1

There is a long-standing controversy regarding the mechanisms that generate the functional subdivisions of the cerebral neocortex. One model proposes that thalamic axonal input specifies these subdivisions; the competing model postulates that patterning mechanisms intrinsic to the dorsal telencephalon generate neocortical regions. Gbx-2 mutant mice, whose thalamic differentiation is disrupted, were investigated. Despite the lack of cortical innervation by thalamic axons, neocortical region-specific gene expression (Cadherin-6, EphA-7, Id-2, and RZR-beta) developed normally. This provides evidence that patterning mechanisms intrinsic to the neocortex specify the basic organization of its functional subdivisions.

1 Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, School of Medicine, University of California San Francisco, San Francisco, CA 94143-0984, USA.
2 Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, CA 94143-0452, USA.
3 Department of Morphological Sciences, Faculty of Medicine, University of Murcia, Institute of Neurosciences, University Miguel Hernandez, Alicante, Spain.
*   These authors contributed equally to this work.

ddagger    To whom correspondence should be addressed. E-mail: jlrr{at}cgl.ucsf.edu

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