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Science 23 July 1999:
Vol. 285. no. 5427, pp. 553 - 556
DOI: 10.1126/science.285.5427.553
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Research Articles

Light-Dependent Sequestration of TIMELESS by CRYPTOCHROME

M. Fernanda Ceriani, 1 Thomas K. Darlington, 1 David Staknis, 2 Paloma Más, 1 Allegra A. Petti, 2 Charles J. Weitz, 2 Steve A. Kay 1*

Most organisms have circadian clocks consisting of negative feedback loops of gene regulation that facilitate adaptation to cycles of light and darkness. In this study, CRYPTOCHROME (CRY), a protein involved in circadian photoperception in Drosophila, is shown to block the function of PERIOD/TIMELESS (PER/TIM) heterodimeric complexes in a light-dependent fashion. TIM degradation does not occur under these conditions; thus, TIM degradation is uncoupled from abrogation of its function by light. CRY and TIM are part of the same complex and directly interact in yeast in a light-dependent fashion. PER/TIM and CRY influence the subcellular distribution of these protein complexes, which reside primarily in the nucleus after the perception of a light signal. Thus, CRY acts as a circadian photoreceptor by directly interacting with core components of the circadian clock.

1 Department of Cell Biology and NSF Center for Biological Timing, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
2 Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
*   To whom correspondence should be addressed.

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   Abstract »    Full Text »    PDF »
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   Abstract »    PDF »
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   Abstract »    PDF »
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H.-Q. Yang, R.-H. Tang, and A. R. Cashmore (2001)
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   Abstract »    Full Text »    PDF »
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R. Toth, E. Kevei, A. Hall, A. J. Millar, F. Nagy, and L. Kozma-Bognar (2001)
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   Abstract »    Full Text »    PDF »
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K. P. Wright Jr., R. J Hughes, R. E. Kronauer, D.-J. Dijk, and C. A. Czeisler (2001)
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   Abstract »    Full Text »    PDF »
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F.-J. Lin, W. Song, E. Meyer-Bernstein, N. Naidoo, and A. Sehgal (2001)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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E. Tauber and B. P. Kyriacou (2001)
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   Abstract »    PDF »
Circadian Photoreception in Drosophila: Functions of Cryptochrome in Peripheral and Central Clocks.
M. Ivanchenko, R. Stanewsky, and J. M. Giebultowicz (2001)
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   Abstract »    PDF »
Circadian Changes in Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase Distribution Inside Individual Chloroplasts Can Account for the Rhythm in Dinoflagellate Carbon Fixation.
N. Nassoury, L. Fritz, and D. Morse (2001)
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   Abstract »    Full Text »
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S. S. Golden and C. Strayer (2001)
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   Full Text »
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C. P. Selby, C. Thompson, T. M. Schmitz, R. N. Van Gelder, and A. Sancar (2000)
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   Abstract »    Full Text »
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J Biol Rhythms 15, 462-470
   Abstract »    PDF »
Cryptochromes Are Required for Phytochrome Signaling to the Circadian Clock but Not for Rhythmicity.
P. F. Devlin and S. A. Kay (2000)
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   Abstract »    Full Text »
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S. M. Reppert and D. R. Weaver (2000)
J Biol Rhythms 15, 357-364
   PDF »
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A. Balsalobre, S. A. Brown, L. Marcacci, F. Tronche, C. Kellendonk, H. M. Reichardt, G. Schütz, and U. Schibler (2000)
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   Abstract »    Full Text »
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I. EDERY (2000)
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   Abstract »    Full Text »    PDF »
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C. Strayer, T. Oyama, T. F. Schultz, R. Raman, D. E. Somers, P. Más, S. Panda, J. A. Kreps, and S. A. Kay (2000)
Science 289, 768-771
   Abstract »    Full Text »
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K. Hitomi, K. Okamoto, H. Daiyasu, H. Miyashita, S. Iwai, H. Toh, M. Ishiura, and T. Todo (2000)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »
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C. Lin (2000)
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K. Bae, C. Lee, P. E. Hardin, and I. Edery (2000)
J. Neurosci. 20, 1746-1753
   Abstract »    Full Text »    PDF »
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A. Piccin, M. Couchman, J. D. Clayton, D. Chalmers, R. Costa, and C. P. Kyriacou (2000)
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   Abstract »    Full Text »
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   Abstract »    PDF »
The circadian clock controls the expression pattern of the circadian input photoreceptor, phytochrome B.
L. K. Bognar, A. Hall, E. Adam, S. C. Thain, F. Nagy, and A. J. Millar (1999)
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   Abstract »    Full Text »    PDF »
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E. A. Griffin Jr., D. Staknis, and C. J. Weitz (1999)
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J. B. Hogenesch, Y.-Z. Gu, S. M. Moran, K. Shimomura, L. A. Radcliffe, J. S. Takahashi, and C. A. Bradfield (2000)
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   Abstract »    Full Text »    PDF »


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