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Science 16 July 1999:
Vol. 285. no. 5426, pp. 403 - 406
DOI: 10.1126/science.285.5426.403
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Reports

Differences in Left-Right Axis Pathways in Mouse and Chick: Functions of FGF8 and SHH

Erik N. Meyers, 12* Gail R. Martin 1dagger

A molecular pathway leading to left-right asymmetry in the chick embryo has been described, in which FGF8 is a right determinant and Sonic Hedgehog a left determinant. Here evidence is presented that the Fgf8 and Sonic Hedgehog genes are required for left-right axis determination in the mouse embryo, but that they have different functions from those previously reported in the chick. In the mouse FGF8 is a left determinant and Sonic Hedgehog is required to prevent left determinants from being expressed on the right.

1 Department of Anatomy and Program in Developmental Biology, School of Medicine, and
2 Department of Pediatrics, School of Medicine, University of California at San Francisco, San Francisco, CA 94143, USA.
*   Present address: Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

dagger    To whom correspondence should be addressed. E-mail: gmartin{at}itsa.ucsf.edu

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