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Science 9 July 1999:
Vol. 285. no. 5425, pp. 260 - 263
DOI: 10.1126/science.285.5425.260
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Reports

BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator

Paul A. Moore, Ornella Belvedere, Amy Orr, Krystyna Pieri, David W. LaFleur, Ping Feng, Daniel Soppet, Meghan Charters, Reiner Gentz, David Parmelee, Yuling Li, Olga Galperina, Judith Giri, Viktor Roschke, Bernardetta Nardelli, Jeffrey Carrell, Svetlana Sosnovtseva, Wilbert Greenfield, Steven M. Ruben, Henrik S. Olsen, James Fikes, David M. Hilbert *

The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS expression on human monocytes could be up-regulated by interferon-gamma . Soluble BLyS functioned as a potent B cell growth factor in costimulation assays. Administration of soluble recombinant BLyS to mice disrupted splenic B and T cell zones and resulted in elevated serum immunoglobulin concentrations. The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation.

Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA.
*   To whom correspondence should be addressed. E-mail: david_hilbert{at}hgsi.com

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Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G1/S transition in opposition to p18INK4c and p27Kip1.
X. Huang, M. Di Liberto, A. F. Cunningham, L. Kang, S. Cheng, S. Ely, H.-c. Liou, I. C. M. MacLennan, and S. Chen-Kiang (2004)
PNAS 101, 17789-17794
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B Cells Expressing Bcl-2 and a Signaling-Impaired BAFF-Specific Receptor Fail to Mature and Are Deficient in the Formation of Lymphoid Follicles and Germinal Centers.
Z. S. M. Rahman and T. Manser (2004)
J. Immunol. 173, 6179-6188
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Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome.
A. J. Novak, D. M. Grote, M. Stenson, S. C. Ziesmer, T. E. Witzig, T. M. Habermann, B. Harder, K. M. Ristow, R. J. Bram, D. F. Jelinek, et al. (2004)
Blood 104, 2247-2253
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Rapid Response of Marginal Zone B Cells to Viral Particles.
D. Gatto, C. Ruedl, B. Odermatt, and M. F. Bachmann (2004)
J. Immunol. 173, 4308-4316
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Inverse association between circulating APRIL levels and serological and clinical disease activity in patients with systemic lupus erythematosus.
W Stohl, S Metyas, S-M Tan, G S Cheema, B Oamar, V Roschke, Y Wu, K P Baker, and D M Hilbert (2004)
Ann Rheum Dis 63, 1096-1103
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B Cell-Activating Factor Belonging to the TNF Family Acts through Separate Receptors to Support B Cell Survival and T Cell-Independent Antibody Formation.
S. Shulga-Morskaya, M. Dobles, M. E. Walsh, L. G. Ng, F. MacKay, S. P. Rao, S. L. Kalled, and M. L. Scott (2004)
J. Immunol. 173, 2331-2341
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Construction and Function of Two Cys146-Mutants with High Activity, Derived from Recombinant Human Soluble B Lymphocyte Stimulator.
G. Chen, S. Peng, M. Zou, H. Xu, D. Xu, and J. Wang (2004)
J. Biochem. 136, 73-79
   Abstract »    Full Text »    PDF »
B Cell Positive Selection: Road Map to the Primary Repertoire?.
M. P. Cancro and J. F. Kearney (2004)
J. Immunol. 173, 15-19
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A therapeutic role for BLyS antagonists.
W Stohl (2004)
Lupus 13, 317-322
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Engineering an APRIL-specific B Cell Maturation Antigen.
D. R. Patel, H. J. A. Wallweber, J. Yin, S. K. Shriver, S. A. Marsters, N. C. Gordon, M. A. Starovasnik, and R. F. Kelley (2004)
J. Biol. Chem. 279, 16727-16735
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BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone.
J. Moreaux, E. Legouffe, E. Jourdan, P. Quittet, T. Reme, C. Lugagne, P. Moine, J.-F. Rossi, B. Klein, and K. Tarte (2004)
Blood 103, 3148-3157
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Impaired IgA class switching in APRIL-deficient mice.
E. Castigli, S. Scott, F. Dedeoglu, P. Bryce, H. Jabara, A. K. Bhan, E. Mizoguchi, and R. S. Geha (2004)
PNAS 101, 3903-3908
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BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex.
H. Hase, Y. Kanno, M. Kojima, K. Hasegawa, D. Sakurai, H. Kojima, N. Tsuchiya, K. Tokunaga, N. Masawa, M. Azuma, et al. (2004)
Blood 103, 2257-2265
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BAFF production by antigen-presenting cells provides T cell co-stimulation.
B. Huard, L. Arlettaz, C. Ambrose, V. Kindler, D. Mauri, E. Roosnek, J. Tschopp, P. Schneider, and L. E. French (2004)
Int. Immunol. 16, 467-475
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Lymphoma B Cells Evade Apoptosis through the TNF Family Members BAFF/BLyS and APRIL.
B. He, A. Chadburn, E. Jou, E. J. Schattner, D. M. Knowles, and A. Cerutti (2004)
J. Immunol. 172, 3268-3279
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APRIL-Deficient Mice Have Normal Immune System Development.
E. Varfolomeev, F. Kischkel, F. Martin, D. Seshasayee, H. Wang, D. Lawrence, C. Olsson, L. Tom, S. Erickson, D. French, et al. (2004)
Mol. Cell. Biol. 24, 997-1006
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Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway.
C. Kern, J.-F. Cornuel, C. Billard, R. Tang, D. Rouillard, V. Stenou, T. Defrance, F. Ajchenbaum-Cymbalista, P.-Y. Simonin, S. Feldblum, et al. (2004)
Blood 103, 679-688
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Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival.
A. J. Novak, J. R. Darce, B. K. Arendt, B. Harder, K. Henderson, W. Kindsvogel, J. A. Gross, P. R. Greipp, and D. F. Jelinek (2004)
Blood 103, 689-694
   Abstract »    Full Text »    PDF »


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