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Science 9 July 1999:
Vol. 285. no. 5425, pp. 215 - 220
DOI: 10.1126/science.285.5425.215
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Review

The Structural Era of Endocytosis

M. Marsh, 1 H. T. McMahon

Endocytosis is crucial for an array of cellular functions and can occur through several distinct mechanisms with the capacity to internalize anything from small molecules to entire cells. The clathrin-mediated endocytic pathway has recently received considerable attention because of (i) the identification of an array of molecules that orchestrate the assembly of clathrin-coated vesicles and the selection of the vesicle cargo and (ii) the resolution of structures for a number of these proteins. Together, these data provide an initial three-dimensional framework for understanding the clathrin endocytic machinery.

1 Medical Research Council Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, UK. E-mail: m.marsh{at}ucl.ac.uk 2Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. E-mail: hmm{at}mrc-lmb.cam.ac.uk

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M. Bailly, J. Wyckoff, B. Bouzahzah, R. Hammerman, V. Sylvestre, M. Cammer, R. Pestell, and J. E. Segall (2000)
Mol. Biol. Cell 11, 3873-3883
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Internalization of Adenovirus by Alveolar Macrophages Initiates Early Proinflammatory Signaling during Acute Respiratory Tract Infection.
Z. Zsengellér, K. Otake, S.-A. Hossain, P.-Y. Berclaz, and B. C. Trapnell (2000)
J. Virol. 74, 9655-9667
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Microtubule and Motor-dependent Endocytic Vesicle Sorting In Vitro.
E. Bananis, J. W. Murray, R. J. Stockert, P. Satir, and A. W. Wolkoff (2000)
J. Cell Biol. 151, 179-186
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NGF Signals through TrkA to Increase Clathrin at the Plasma Membrane and Enhance Clathrin-Mediated Membrane Trafficking.
E. C. Beattie, C. L. Howe, A. Wilde, F. M. Brodsky, and W. C. Mobley (2000)
J. Neurosci. 20, 7325-7333
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Constitutive Macropinocytosis in Oncogene-transformed Fibroblasts Depends on Sequential Permanent Activation of Phosphoinositide 3-Kinase and Phospholipase C.
M. Amyere, B. Payrastre, U. Krause, P. V. D. Smissen, A. Veithen, and P. J. Courtoy (2000)
Mol. Biol. Cell 11, 3453-3467
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Tyrosine Phosphorylation of Eps15 Is Required for Ligand-regulated, but Not Constitutive, Endocytosis.
S. Confalonieri, A. E. Salcini, C. Puri, C. Tacchetti, and P. P. Di Fiore (2000)
J. Cell Biol. 150, 905-912
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Effects of Truncation of the Carboxy Terminus of Pseudorabies Virus Glycoprotein B on Infectivity.
R. Nixdorf, B. G. Klupp, A. Karger, and T. C. Mettenleiter (2000)
J. Virol. 74, 7137-7145
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Regulation of neuronal function by protein trafficking: a role for the endosomal pathway.
K. M Buckley, H. E Melikian, C. J Provoda, and M. T Waring (2000)
J. Physiol. 525, 11-19
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The Class II Phosphoinositide 3-Kinase PI3K-C2alpha Is Concentrated in the Trans-Golgi Network and Present in Clathrin-coated Vesicles.
J. Domin, I. Gaidarov, M. E. K. Smith, J. H. Keen, and M. D. Waterfield (2000)
J. Biol. Chem. 275, 11943-11950
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A Family of Proteins with {gamma}-Adaptin and VHS Domains that Facilitate Trafficking between the Trans-Golgi Network and the Vacuole/Lysosome.
J. Hirst, W. W.Y. Lui, N. A. Bright, N. Totty, M. N.J. Seaman, and M. S. Robinson (2000)
J. Cell Biol. 149, 67-80
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Schwann Cell Myelination Requires Timely and Precise Targeting of P0 Protein.
X. Yin, G.J. Kidd, L. Wrabetz, M.L. Feltri, A. Messing, and B.D. Trapp (2000)
J. Cell Biol. 148, 1009-1020
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Syndapin Isoforms Participate in Receptor-mediated Endocytosis and Actin Organization.
B. Qualmann and R. B. Kelly (2000)
J. Cell Biol. 148, 1047-1062
   Abstract »    Full Text »    PDF »
GCP-2-induced internalization of IL-8 receptors: hierarchical relationships between GCP-2 and other ELR+-CXC chemokines and mechanisms regulating CXCR2 internalization and recycling.
R. Feniger-Barish, D. Belkin, A. Zaslaver, S. Gal, M. Dori, M. Ran, and A. Ben-Baruch (2000)
Blood 95, 1551-1559
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