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Science 2 July 1999:
Vol. 285. no. 5424, pp. 113 - 116
DOI: 10.1126/science.285.5424.113
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Reports

Positive Selection of Natural Autoreactive B Cells

Kyoko Hayakawa, 1* Masanao Asano, 1 Susan A. Shinton, 1 Ming Gui, 1 David Allman, 1 Colin L. Stewart, 2 Jack Silver, 3 Richard R. Hardy 1

Lymphocyte development is critically influenced by self-antigens. T cells are subject to both positive and negative selection, depending on their degree of self-reactivity. Although B cells are subject to negative selection, it has been difficult to test whether self-antigen plays any positive role in B cell development. A murine model system of naturally generated autoreactive B cells with a germ line gene-encoded specificity for the Thy-1 (CD90) glycoprotein was developed, in which the presence of self-antigen promotes B cell accumulation and serum autoantibody secretion. Thus, B cells can be subject to positive selection, generated, and maintained on the basis of their autoreactivity.

1 Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA.
2 Laboratory of Cancer and Developmental Biology, ABL-Basic Research Program, National Cancer Institute-Fredrick Cancer Research and Development Center, Fredrick, MD 21702, USA.
3 Division of Molecular Medicine, North Shore University Hospital, Cornell University Medical College, Manhasset, NY 11030, USA.
*   To whom correspondence should be addressed. E-mail: K_Hayakawa{at}fccc.edu

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Immunomodulation of Autoimmune and Inflammatory Diseases with Intravenous Immune Globulin.
M. D. Kazatchkine and S. V. Kaveri (2001)
N. Engl. J. Med. 345, 747-755
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Interference with Immunoglobulin (Ig){alpha} Immunoreceptor Tyrosine-Based Activation Motif (Itam) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Ig{beta} Cytoplasmic Tail.
M. Kraus, L. I. Pao, A. Reichlin, Y. Hu, B. Canono, J. C. Cambier, M. C. Nussenzweig, and K. Rajewsky (2001)
J. Exp. Med. 194, 455-470
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Antibodies to C-C Chemokine Receptor 5 in Normal Human IgG Block Infection of Macrophages and Lymphocytes with Primary R5-Tropic Strains of HIV-1.
H. Bouhlal, H. Hocini, C. Quillent-Gregoire, V. Donkova, S. Rose, A. Amara, R. Longhi, N. Haeffner-Cavaillon, A. Beretta, S. V. Kaveri, et al. (2001)
J. Immunol. 166, 7606-7611
   Abstract »    Full Text »    PDF »
T cell control of the gut IgA response against commensal bacteria.
N A BOS, H-Q JIANG, and J J CEBRA (2001)
Gut 48, 762-764
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The Mouse Cd1d-Restricted Repertoire Is Dominated by a Few Autoreactive T Cell Receptor Families.
S.-H. Park, A. Weiss, K. Benlagha, T. Kyin, L. Teyton, and A. Bendelac (2001)
J. Exp. Med. 193, 893-904
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Anti-Sm B Cell Differentiation in Ig Transgenic MRL/Mp-lpr/lpr Mice: Altered Differentiation and an Accelerated Response.
S. Santulli-Marotto, Y. Qian, S. Ferguson, and S. H. Clarke (2001)
J. Immunol. 166, 5292-5299
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Predominance of a novel splenic B cell population in mice expressing a transgene that encodes multireactive antibodies: support for additional heterogeneity of the B cell compartment.
K. M. Tumas-Brundage, E. Notidis, L. Heltemes, X. Zhang, L. J. Wysocki, and T. Manser (2001)
Int. Immunol. 13, 475-484
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Expression of a V Region-Less B Cell Receptor Confers a Tolerance-Like Phenotype on Transgenic B Cells.
D. Corcos, A. Grandien, A. Vazquez, O. Dunda, P. Lores, and D. Bucchini (2001)
J. Immunol. 166, 3083-3089
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Antigen Receptor Proximal Signaling in Splenic B-2 Cell Subsets.
X. Li, F. Martin, A. M. Oliver, J. F. Kearney, and R. H. Carter (2001)
J. Immunol. 166, 3122-3129
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Cutting Edge Commentary: Origins of B-1 Cells.
H. H. Wortis and R. Berland (2001)
J. Immunol. 166, 2163-2166
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Natural Autoreactive B Cells in Transgenic Mice Reproduce an Apparent Paradox to the Clonal Tolerance Theory.
S. Koenig-Marrony, P. Soulas, S. Julien, A.-M. Knapp, J.-C. Garaud, T. Martin, and J.-L. Pasquali (2001)
J. Immunol. 166, 1463-1470
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Annexin V Binds to Positively Selected B Cells.
S. R. Dillon, A. Constantinescu, and M. S. Schlissel (2001)
J. Immunol. 166, 58-71
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