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Science 18 June 1999:
Vol. 284. no. 5422, pp. 1991 - 1994
DOI: 10.1126/science.284.5422.1991
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Reports

Requirement for Croquemort in Phagocytosis of Apoptotic Cells in Drosophila

Nathalie C. Franc, 1 Pascal Heitzler, 4 R. Alan B. , Ezekowitz, 23 Kristin White 1*

Macrophages in the Drosophila embryo are responsible for the phagocytosis of apoptotic cells and are competent to engulf bacteria. Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages. Genetic evidence showed that crq was essential for efficient phagocytosis of apoptotic corpses but was not required for the engulfment of bacteria. The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila.

1 Cutaneous Biology Research Center,
2 Laboratory of Developmental Immunology, and
3 Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School. Charlestown, MA 02129, USA.
4 Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Université Louis Pasteur de Strasbourg (CNRS/INSERM/ULP), 67404 Illkirch Cedex, France.
*   To whom correspondence should be addressed. E-mail: kristin.white{at}CBRC2.MGH.Harvard.edu

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