Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 18 June 1999:
Vol. 284. no. 5422, pp. 1982 - 1984
DOI: 10.1126/science.284.5422.1982
Prev | Table of Contents | Next

Reports

Gating of BDNF-Induced Synaptic Potentiation by cAMP

Lisa Boulanger, Mu-ming Poo *

Neurotrophins have been implicated in activity-dependent synaptic plasticity, but the underlying intracellular mechanisms remain largely unknown. Synaptic potentiation induced by brain-derived neurotrophic factor (BDNF), but not neurotrophin 3, was prevented by blockers of adenosine 3',5'-monophosphate (cAMP) signaling. Activators of cAMP signaling alone were ineffective in modifying synaptic efficacy but greatly enhanced the potentiation effect of BDNF. Blocking cAMP signaling abolished the facilitation of BDNF-induced potentiation by presynaptic activity. Thus synaptic actions of BDNF are gated by cAMP. Activity and other coincident signals that modulate cAMP concentrations may specify the action of secreted neurotrophins on developing nerve terminals.

Department of Biology, University of California at San Diego, La Jolla, CA 92093-0357, USA.
*   To whom correspondence should be addressed. E-mail: mpoo{at}ucsd.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Autocrine Activation of Neuronal NMDA Receptors by Aspartate Mediates Dopamine- and cAMP-Induced CREB-Dependent Gene Transcription.
L. E. F. Almeida, P. D. Murray, H. R. Zielke, C. D. Roby, T. J. Kingsbury, and B. K. Krueger (2009)
J. Neurosci. 29, 12702-12710
   Abstract »    Full Text »    PDF »
At Immature Mossy-Fiber-CA3 Synapses, Correlated Presynaptic and Postsynaptic Activity Persistently Enhances GABA Release and Network Excitability via BDNF and cAMP-Dependent PKA.
S. Sivakumaran, M. H. Mohajerani, and E. Cherubini (2009)
J. Neurosci. 29, 2637-2647
   Abstract »    Full Text »    PDF »
Altered development of the brain after focal herpesvirus infection of the central nervous system.
T. Koontz, M. Bralic, J. Tomac, E. Pernjak-Pugel, G. Bantug, S. Jonjic, and W. J. Britt (2008)
J. Exp. Med. 205, 423-435
   Abstract »    Full Text »    PDF »
Postsynaptic Secretion of BDNF and NT-3 from Hippocampal Neurons Depends on Calcium Calmodulin Kinase II Signaling and Proceeds via Delayed Fusion Pore Opening.
R. Kolarow, T. Brigadski, and V. Lessmann (2007)
J. Neurosci. 27, 10350-10364
   Abstract »    Full Text »    PDF »
Protecting Motor Neurons from Toxic Insult by Antagonism of Adenosine A2a and Trk Receptors.
J. Mojsilovic-Petrovic, G.-B. Jeong, A. Crocker, A. Arneja, S. David, D. Russell, and R. G. Kalb (2006)
J. Neurosci. 26, 9250-9263
   Abstract »    Full Text »    PDF »
Activation of Adenosine A2A Receptor Facilitates Brain-Derived Neurotrophic Factor Modulation of Synaptic Transmission in Hippocampal Slices.
M. J. Diogenes, C. C. Fernandes, A. M. Sebastiao, and J. A. Ribeiro (2004)
J. Neurosci. 24, 2905-2913
   Abstract »    Full Text »    PDF »
Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein.
D. Thomas, W. Zhang, K. Wu, A.-B. Wimmer, B. Gut, G. Wendt-Nordahl, S. Kathofer, V. A.W. Kreye, H. A. Katus, W. Schoels, et al. (2003)
Cardiovasc Res 59, 14-26
   Abstract »    Full Text »    PDF »
The Role of the Hyperpolarization-Activated Cationic Current Ih in the Timing of Interictal Bursts in the Neonatal Hippocampus.
A. Agmon and J. E. Wells (2003)
J. Neurosci. 23, 3658-3668
   Abstract »    Full Text »    PDF »
BDNF and Activity-Dependent Synaptic Modulation.
B. Lu (2003)
Learn. Mem. 10, 86-98
   Abstract »    Full Text »    PDF »
Plasticity in Respiratory Motor Control: Invited Review: Neuroplasticity in respiratory motor control.
G. S. Mitchell and S. M. Johnson (2003)
J Appl Physiol 94, 358-374
   Abstract »    Full Text »    PDF »
Transient PKA Activity Is Required for Initiation But Not Maintenance of BDNF-Mediated Protection from Nitric Oxide-Induced Growth-Cone Collapse.
G. Gallo, A. F. Ernst, S. C. McLoon, and P. C. Letourneau (2002)
J. Neurosci. 22, 5016-5023
   Abstract »    Full Text »    PDF »
Neurotrophin-3 inhibits HCO3- absorption via a cAMP-dependent pathway in renal thick ascending limb.
D. W. Good and T. George (2001)
Am J Physiol Cell Physiol 281, C1804-C1811
   Abstract »    Full Text »    PDF »
Rab3A Is Required for Brain-Derived Neurotrophic Factor-Induced Synaptic Plasticity: Transcriptional Analysis at the Population and Single-Cell Levels.
S. Thakker-Varia, J. Alder, R. A. Crozier, M. R. Plummer, and I. B. Black (2001)
J. Neurosci. 21, 6782-6790
   Abstract »    Full Text »    PDF »
Nerve Growth Factor Rapidly Induces Prolonged Acetylcholine Release from Cultured Basal Forebrain Neurons: Differentiation between Neuromodulatory and Neurotrophic Influences.
D. S. Auld, F. Mennicken, and R. Quirion (2001)
J. Neurosci. 21, 3375-3382
   Abstract »    Full Text »    PDF »
Environmental Enrichment Modifies the PKA-Dependence of Hippocampal LTP and Improves Hippocampus-Dependent Memory.
S. N. Duffy, K. J. Craddock, T. Abel, and P. V. Nguyen (2001)
Learn. Mem. 8, 26-34
   Abstract »    Full Text »
Differential cAMP Gating of Glutamatergic Signaling Regulates Long-Term State Changes in the Suprachiasmatic Circadian Clock.
S. A. Tischkau, E. A. Gallman, G. F. Buchanan, and M. U. Gillette (2000)
J. Neurosci. 20, 7830-7837
   Abstract »    Full Text »    PDF »
Brain-Derived Neurotrophic Factor Differentially Regulates Excitatory and Inhibitory Synaptic Transmission in Hippocampal Cultures.
M. M. Bolton, A. J. Pittman, and D. C. Lo (2000)
J. Neurosci. 20, 3221-3232
   Abstract »    Full Text »    PDF »
Protein Synthesis-dependent and -independent Regulation of Hippocampal Synapses by Brain-derived Neurotrophic Factor.
N. Tartaglia, J. Du, W. J. Tyler, E. Neale, L. Pozzo-Miller, and B. Lu (2001)
J. Biol. Chem. 276, 37585-37593
   Abstract »    Full Text »    PDF »
Neurotrophic Factor Expression After CNS Viral Injury Produces Enhanced Sensitivity to Psychostimulants: Potential Mechanism for Addiction Vulnerability.
M. V. Solbrig, G. F. Koob, L. H. Parsons, T. Kadota, N. Horscroft, T. Briese, and W. I. Lipkin (2000)
J. Neurosci. 20, RC104
   Abstract »    Full Text »    PDF »
Different Signaling Pathways Mediate Regenerative versus Developmental Sensory Axon Growth.
R.-Y. Liu and W. D. Snider (2001)
J. Neurosci. 21, RC164
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)