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Science 11 June 1999:
Vol. 284. no. 5421, pp. 1835 - 1837
DOI: 10.1126/science.284.5421.1835
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Reports

The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood

Frederick P. Siegal, 1* Norimitsu Kadowaki, 2 Michael Shodell, 3 Patricia A. Fitzgerald-Bocarsly, 4 Kokila Shah, 1 Stephen Ho, 2 Svetlana Antonenko, 2 Yong-Jun Liu 2*

Interferons (IFNs) are the most important cytokines in antiviral immune responses. "Natural IFN-producing cells" (IPCs) in human blood express CD4 and major histocompatibility complex class II proteins, but have not been isolated and further characterized because of their rarity, rapid apoptosis, and lack of lineage markers. Purified IPCs are here shown to be the CD4+CD11c- type 2 dendritic cell precursors (pDC2s), which produce 200 to 1000 times more IFN than other blood cells after microbial challenge. pDC2s are thus an effector cell type of the immune system, critical for antiviral and antitumor immune responses.

1 Saint Vincents Hospital and Medical Center, New York, NY 10011, and Long Island Jewish Medical Center-Albert Einstein College of Medicine, New Hyde Park, NY 11040, USA.
2 DNAX Research Institute, Palo Alto, CA 94304, USA.
3 The CW Post Campus of Long Island University, Brookville, NY 11548, USA.
4 University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ 07103, USA.
*   To whom correspondence should be addressed.

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   Abstract »    Full Text »    PDF »
Activation of Plasmacytoid Dendritic Cells with TLR9 Agonists Initiates Invariant NKT Cell-Mediated Cross-Talk with Myeloid Dendritic Cells.
C. J. Montoya, H.-B. Jie, L. Al-Harthi, C. Mulder, P. J. Patino, M. T. Rugeles, A. M. Krieg, A. L. Landay, and S. B. Wilson (2006)
J. Immunol. 177, 1028-1039
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Plasmacytoid dendritic cell-specific receptor ILT7-Fc{varepsilon}RI{gamma} inhibits Toll-like receptor-induced interferon production.
W. Cao, D. B. Rosen, T. Ito, L. Bover, M. Bao, G. Watanabe, Z. Yao, L. Zhang, L. L. Lanier, and Y.-J. Liu (2006)
J. Exp. Med. 203, 1399-1405
   Abstract »    Full Text »    PDF »
Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms.
G. Cheng, J. Zhong, and F. V. Chisari (2006)
PNAS 103, 8499-8504
   Abstract »    Full Text »    PDF »
Neurons produce type I interferon during viral encephalitis.
S. Delhaye, S. Paul, G. Blakqori, M. Minet, F. Weber, P. Staeheli, and T. Michiels (2006)
PNAS 103, 7835-7840
   Abstract »    Full Text »    PDF »
Differential expression of IFN-{alpha} and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients.
J.-P. Herbeuval, J. Nilsson, A. Boasso, A. W. Hardy, M. J. Kruhlak, S. A. Anderson, M. J. Dolan, M. Dy, J. Andersson, and G. M. Shearer (2006)
PNAS 103, 7000-7005
   Abstract »    Full Text »    PDF »
Lambda Interferon (IFN-{lambda}), a Type III IFN, Is Induced by Viruses and IFNs and Displays Potent Antiviral Activity against Select Virus Infections In Vivo.
N. Ank, H. West, C. Bartholdy, K. Eriksson, A. R. Thomsen, and S. R. Paludan (2006)
J. Virol. 80, 4501-4509
   Abstract »    Full Text »    PDF »
Alpha and lambda interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virus..
B. Chi, H. L. Dickensheets, K. M. Spann, M. A. Alston, C. Luongo, L. Dumoutier, J. Huang, J.-C. Renauld, S. V. Kotenko, M. Roederer, et al. (2006)
J. Virol. 80, 5032-5040
   Abstract »    Full Text »    PDF »
Differential Restoration of Myeloid and Plasmacytoid Dendritic Cells in HIV-1-Infected Children after Treatment with Highly Active Antiretroviral Therapy.
Z. Zhang, J. Fu, Q. Zhao, Y. He, L. Jin, H. Zhang, J. Yao, L. Zhang, and F.-S. Wang (2006)
J. Immunol. 176, 5644-5651
   Abstract »    Full Text »    PDF »
Impaired maturation and altered regulatory function of plasmacytoid dendritic cells in multiple sclerosis.
M. Stasiolek, A. Bayas, N. Kruse, A. Wieczarkowiecz, K. V. Toyka, R. Gold, and K. Selmaj (2006)
Brain 129, 1293-1305
   Abstract »    Full Text »    PDF »
Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL).
S. Hanabuchi, N. Watanabe, Y.-H. Wang, Y.-H. Wang, T. Ito, J. Shaw, W. Cao, F. X.-F. Qin, and Y.-J. Liu (2006)
Blood 107, 3617-3623
   Abstract »    Full Text »    PDF »
Cutting edge: CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion..
P. Aichele, H. Unsoeld, M. Koschella, O. Schweier, U. Kalinke, and S. Vucikuja (2006)
J. Immunol. 176, 4525-4529
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Dendritic Cells and HIV Infection: Activating Dendritic Cells to Boost Immunity.
N. Teleshova, J. Kenney, and M. Robbiani (2006)
Advances in Dental Research 19, 36-41
   Abstract »    Full Text »    PDF »
Upon viral exposure, myeloid and plasmacytoid dendritic cells produce 3 waves of distinct chemokines to recruit immune effectors.
B. Piqueras, J. Connolly, H. Freitas, A. K. Palucka, and J. Banchereau (2006)
Blood 107, 2613-2618
   Abstract »    Full Text »    PDF »
Innate Immune Responses to Herpes Simplex Virus Type 2 Influence Skin Homing Molecule Expression by Memory CD4+ Lymphocytes.
D. M. Koelle, J. Huang, M. T. Hensel, and C. L. McClurkan (2006)
J. Virol. 80, 2863-2872
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Distinct Subsets of Dendritic Cells Regulate the Pattern of Acute Xenograft Rejection and Susceptibility to Cyclosporine Therapy.
H. Wang, J. Arp, X. Huang, W. Liu, S. Ramcharran, J. Jiang, B. Garcia, N. Kanai, W. Min, P. J. O'Connell, et al. (2006)
J. Immunol. 176, 3525-3535
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Fms-Like Tyrosine Kinase 3 Ligand Recruits Plasmacytoid Dendritic Cells to the Brain.
J. F. Curtin, G. D. King, C. Barcia, C. Liu, F. X. Hubert, C. Guillonneau, R. Josien, I. Anegon, P. R. Lowenstein, and M. G. Castro (2006)
J. Immunol. 176, 3566-3577
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Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells.
T. Ito, H. Kanzler, O. Duramad, W. Cao, and Y.-J. Liu (2006)
Blood 107, 2423-2431
   Abstract »    Full Text »    PDF »


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