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Science 11 June 1999:
Vol. 284. no. 5421, pp. 1811 - 1816
DOI: 10.1126/science.284.5421.1811
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Research Articles

Rapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation

Song-Hai Shi, 1 Yasunori Hayashi, 1 Ronald S. Petralia, 2 Shahid H. Zaman, 1 Robert J. Wenthold, 2 Karel Svoboda, 1 Roberto Malinow 1*

To monitor changes in alpha -amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor distribution in living neurons, the AMPA receptor subunit GluR1 was tagged with green fluorescent protein (GFP). This protein (GluR1-GFP) was functional and was transiently expressed in hippocampal CA1 neurons. In dendrites visualized with two-photon laser scanning microscopy or electron microscopy, most of the GluR1-GFP was intracellular, mimicking endogenous GluR1 distribution. Tetanic synaptic stimulation induced a rapid delivery of tagged receptors into dendritic spines as well as clusters in dendrites. These postsynaptic trafficking events required synaptic N-methyl-D-aspartate (NMDA) receptor activation and may contribute to the enhanced AMPA receptor-mediated transmission observed during long-term potentiation and activity-dependent synaptic maturation.

1 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
2 Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892-4162, USA.
*   To whom correspondence should be addressed. E-mail: malinow{at}cshl.org

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'Deaf, mute and whispering' silent synapses: their role in synaptic plasticity.
L. L. Voronin and E. Cherubini (2004)
J. Physiol. 557, 3-12
   Abstract »    Full Text »    PDF »
Trans-Endocytosis via Spinules in Adult Rat Hippocampus.
J. Spacek and K. M. Harris (2004)
J. Neurosci. 24, 4233-4241
   Abstract »    Full Text »    PDF »
Dynamic Interaction of Stargazin-like TARPs with Cycling AMPA Receptors at Synapses.
S. Tomita, M. Fukata, R. A. Nicoll, and D. S. Bredt (2004)
Science 303, 1508-1511
   Abstract »    Full Text »    PDF »
Clathrin-mediated endocytosis is required for compensatory regulation of GLR-1 glutamate receptors after activity blockade.
M. E. Grunwald, J. E. Mellem, N. Strutz, A. V. Maricq, and J. M. Kaplan (2004)
PNAS 101, 3190-3195
   Abstract »    Full Text »    PDF »
Postsynaptic Density 95 controls AMPA Receptor Incorporation during Long-Term Potentiation and Experience-Driven Synaptic Plasticity.
I. Ehrlich and R. Malinow (2004)
J. Neurosci. 24, 916-927
   Abstract »    Full Text »    PDF »
Trans-Golgi network delivery of synaptic proteins in synaptogenesis.
V. Sytnyk, I. Leshchyns'ka, A. Dityatev, and M. Schachner (2004)
J. Cell Sci. 117, 381-388
   Abstract »    Full Text »    PDF »
Epileptiform activity in rat hippocampus strengthens excitatory synapses.
M. H. Abegg, N. Savic, M. U. Ehrengruber, R. A. McKinney, and B. H. Gahwiler (2004)
J. Physiol. 554, 439-448
   Abstract »    Full Text »    PDF »
Long-Term Potentiation and Memory.
M. A. LYNCH (2004)
Physiol Rev 84, 87-136
   Abstract »    Full Text »    PDF »
Elevated Intracellular Calcium Triggers Recruitment of the Receptor Cross-talk Accessory Protein Calcyon to the Plasma Membrane.
M. K. Ali and C. Bergson (2003)
J. Biol. Chem. 278, 51654-51663
   Abstract »    Full Text »    PDF »
A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A.
V. Jensen, K. M M Kaiser, T. Borchardt, G. Adelmann, A. Rozov, N. Burnashev, C. Brix, M. Frotscher, P. Andersen, O. Hvalby, et al. (2003)
J. Physiol. 553, 843-856
   Abstract »    Full Text »    PDF »
Distribution of Postsynaptic Density (PSD)-95 and Ca2+/Calmodulin-Dependent Protein Kinase II at the PSD.
J. D. Petersen, X. Chen, L. Vinade, A. Dosemeci, J. E. Lisman, and T. S. Reese (2003)
J. Neurosci. 23, 11270-11278
   Abstract »    Full Text »    PDF »
Suppression of L-Type Voltage-Gated Calcium Channel-Dependent Synaptic Plasticity by Ethanol: Analysis of Miniature Synaptic Currents and Dendritic Calcium Transients.
A. W. Hendricson, M. P. Thomas, M. J. Lippmann, and R. A. Morrisett (2003)
J. Pharmacol. Exp. Ther. 307, 550-558
   Abstract »    Full Text »    PDF »


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