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Science 21 May 1999: Vol. 284. no. 5418, pp. 1328 - 1333 DOI: 10.1126/science.284.5418.1328
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Review
Helicobacter pylori Virulence and Genetic Geography
Antonello Covacci,
1
John L. Telford,
1
Giuseppe Del Giudice,
1
Julie Parsonnet,
2
Rino Rappuoli
1*
Isolated for the first time in 1982 from human
gastric biopsy, Helicobacter pylori is responsible for
gastritis, peptic ulcer, and gastric cancer. A pathogenicity island
acquired by horizontal transfer, coding for a type IV secretion system,
is a major determinant of virulence. The infection is now treated with
antibiotics, and vaccines are in preparation. The geographic
distribution suggests coevolution of man and Helicobacter
pylori.
1 IRIS, Chiron SpA, Via Fiorentina 1, 53100 Siena, Italy.
2 Department of Medicine/Infectious
Diseases Hrp T152, Stanford University, CA 94305, USA.
*
To whom correspondence should be addressed. E-mail:
rappuoli{at}iris02.biocine.it
Read the Full Text
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- Virulence Genes and Neutral DNA Markers of Helicobacter pylori Isolates from Different Ethnic Communities of West Bengal, India.
- S. Datta, S. Chattopadhyay, G. Balakrish Nair, A. K. Mukhopadhyay, J. Hembram, D. E. Berg, D. Rani Saha, A. Khan, A. Santra, S. K. Bhattacharya, et al. (2003)
J. Clin. Microbiol.
41, 3737-3743
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- Tooth loss, pancreatic cancer, and Helicobacter pylori.
- R. Z Stolzenberg-Solomon, K. W Dodd, M. J Blaser, J. Virtamo, P. R Taylor, and D. Albanes (2003)
Am. J. Clinical Nutrition
78, 176-181
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- Antigenic Properties of HpaA and Omp18, Two Outer Membrane Proteins of Helicobacter pylori.
- P. Voland, N. Hafsi, M. Zeitner, S. Laforsch, H. Wagner, and C. Prinz (2003)
Infect. Immun.
71, 3837-3843
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- pH-Regulated Gene Expression of the Gastric Pathogen Helicobacter pylori.
- D. S. Merrell, M. L. Goodrich, G. Otto, L. S. Tompkins, and S. Falkow (2003)
Infect. Immun.
71, 3529-3539
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- Conjugative Plasmid Transfer in Gram-Positive Bacteria.
- E. Grohmann, G. Muth, and M. Espinosa (2003)
Microbiol. Mol. Biol. Rev.
67, 277-301
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- Development of an Interleukin-12-Deficient Mouse Model That Is Permissive for Colonization by a Motile KE26695 Strain of Helicobacter pylori.
- P. S. Hoffman, N. Vats, D. Hutchison, J. Butler, K. Chisholm, G. Sisson, A. Raudonikiene, J. S. Marshall, and S. J. O. Veldhuyzen van Zanten (2003)
Infect. Immun.
71, 2534-2541
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- Agrobacterium tumefaciens VirB6 Protein Participates in Formation of VirB7 and VirB9 Complexes Required for Type IV Secretion.
- S. J. Jakubowski, V. Krishnamoorthy, and P. J. Christie (2003)
J. Bacteriol.
185, 2867-2878
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- Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response.
- Y. Churin, L. Al-Ghoul, O. Kepp, T. F. Meyer, W. Birchmeier, and M. Naumann (2003)
J. Cell Biol.
161, 249-255
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- Type III secretion systems and bacterial flagella: Insights into their function from structural similarities.
- A. Blocker, K. Komoriya, and S.-I. Aizawa (2003)
PNAS
100, 3027-3030
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- Traces of Human Migrations in Helicobacter pylori Populations.
- D. Falush, T. Wirth, B. Linz, J. K. Pritchard, M. Stephens, M. Kidd, M. J. Blaser, D. Y. Graham, S. Vacher, G. I. Perez-Perez, et al. (2003)
Science
299, 1582-1585
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- Production of the Type IV Secretion System Differs among Brucella Species as Revealed with VirB5- and VirB8-Specific Antisera.
- B. Rouot, M.-T. Alvarez-Martinez, C. Marius, P. Menanteau, L. Guilloteau, R.-A. Boigegrain, R. Zumbihl, D. O'Callaghan, N. Domke, and C. Baron (2003)
Infect. Immun.
71, 1075-1082
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- Helicobacter Pylori Infection and Gastric Cancer.
- P. Correa (2003)
Cancer Epidemiol. Biomarkers Prev.
12, 238s-241s
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- Up-regulated Smad5 Mediates Apoptosis of Gastric Epithelial Cells Induced by Helicobacter pylori Infection.
- T. Nagasako, T. Sugiyama, T. Mizushima, Y. Miura, M. Kato, and M. Asaka (2003)
J. Biol. Chem.
278, 4821-4825
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- Helicobacter pylori genotyping in gastric adenocarcinoma and MALT lymphoma by multiplex PCR analyses of paraffin wax embedded tissues.
- C I Koehler, M B Mues, H P Dienes, J Kriegsmann, P Schirmacher, and M Odenthal (2003)
Mol. Pathol.
56, 36-42
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- Attenuation of Helicobacter pylori CagA{middle dot}SHP-2 Signaling by Interaction between CagA and C-terminal Src Kinase.
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J. Biol. Chem.
278, 3664-3670
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- Interactions among the seven Helicobacter pylori proteins encoded by the urease gene cluster.
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Am J Physiol Gastrointest Liver Physiol
284, G96-G106
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- Proteins Released by Helicobacter pylori In Vitro.
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J. Bacteriol.
184, 6155-6162
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- DNA Sequence and Mutational Analyses of the pVir Plasmid of Campylobacter jejuni 81-176.
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Infect. Immun.
70, 6242-6250
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- Secretion of {alpha}-Amylase from Pseudoalteromonas haloplanktis TAB23: Two Different Pathways in Different Hosts.
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J. Bacteriol.
184, 5814-5817
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- Two Predicted Chemoreceptors of Helicobacter pylori Promote Stomach Infection.
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Infect. Immun.
70, 5877-5881
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- Detergent extraction identifies different VirB protein subassemblies of the type IV secretion machinery in the membranes of Agrobacteriumtumefaciens.
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PNAS
99, 11405-11410
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- Helicobacter pylori induces apoptosis of rat gastric parietal cells.
- B. Neu, P. Randlkofer, M. Neuhofer, P. Voland, A. Mayerhofer, M. Gerhard, W. Schepp, and C. Prinz (2002)
Am J Physiol Gastrointest Liver Physiol
283, G309-G318
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- Identification of Surface Proteins of Helicobacter pylori by Selective Biotinylation, Affinity Purification, and Two-dimensional Gel Electrophoresis.
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J. Biol. Chem.
277, 27896-27902
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