Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 21 May 1999:
Vol. 284. no. 5418, pp. 1328 - 1333
DOI: 10.1126/science.284.5418.1328

Review

Helicobacter pylori Virulence and Genetic Geography

Antonello Covacci, 1 John L. Telford, 1 Giuseppe Del Giudice, 1 Julie Parsonnet, 2 Rino Rappuoli 1*

Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori.

1 IRIS, Chiron SpA, Via Fiorentina 1, 53100 Siena, Italy.
2 Department of Medicine/Infectious Diseases Hrp T152, Stanford University, CA 94305, USA.
*   To whom correspondence should be addressed. E-mail: rappuoli{at}iris02.biocine.it


Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Interleukin-1 Beta Single-Nucleotide Polymorphism's C Allele is Associated with Elevated Risk of Gastric Cancer in Helicobacter pylori-Infected Peruvians.
S. Gehmert, B. Velapatino, P. Herrera, J. Balqui, L. Santivanez, J. Cok, G. Vargas, J. Combe, D. J. Passaro, S. Wen, et al. (2009)
Am J Trop Med Hyg 81, 804-810
   Abstract »    Full Text »    PDF »
Evaluation of the Anti-East Asian CagA-Specific Antibody for CagA Phenotyping.
L. T. Nguyen, T. Uchida, A. Kuroda, Y. Tsukamoto, T. D. Trinh, L. Ta, H. B. Mai, D. Q. D. Ho, H. H. Hoang, R.-K. Vilaichone, et al. (2009)
Clin. Vaccine Immunol. 16, 1687-1692
   Abstract »    Full Text »    PDF »
Role of Partitioning-defective 1/Microtubule Affinity-regulating Kinases in the Morphogenetic Activity of Helicobacter pylori CagA.
H. Lu, N. Murata-Kamiya, Y. Saito, and M. Hatakeyama (2009)
J. Biol. Chem. 284, 23024-23036
   Abstract »    Full Text »    PDF »
Helicobacter pylori CagA Causes Mitotic Impairment and Induces Chromosomal Instability.
M. Umeda, N. Murata-Kamiya, Y. Saito, Y. Ohba, M. Takahashi, and M. Hatakeyama (2009)
J. Biol. Chem. 284, 22166-22172
   Abstract »    Full Text »    PDF »
Conjugative Type 4 Secretion System of a Novel Large Plasmid from the Chemoautotroph Tetrathiobacter kashmirensis and Construction of Shuttle Vectors for Alcaligenaceae.
B. Dam, W. Ghosh, and S. K. Das Gupta (2009)
Appl. Envir. Microbiol. 75, 4362-4373
   Abstract »    Full Text »    PDF »
Vertical Helicobacter pylori transmission from Mongolian gerbil mothers to pups.
I. Oshio, T. Osaki, T. Hanawa, H. Yonezawa, C. Zaman, S. Kurata, and S. Kamiya (2009)
J. Med. Microbiol. 58, 656-662
   Abstract »    Full Text »    PDF »
Roles of gastric mucin-type O-glycans in the pathogenesis of Helicobacter pylori infection.
M. Kobayashi, H. Lee, J. Nakayama, and M. Fukuda (2009)
Glycobiology 19, 453-461
   Abstract »    Full Text »    PDF »
The 3'-to-5' Exoribonuclease (Encoded by HP1248) of Helicobacter pylori Regulates Motility and Apoptosis-Inducing Genes.
M.-Y. Tsao, T.-L. Lin, P.-F. Hsieh, and J.-T. Wang (2009)
J. Bacteriol. 191, 2691-2702
   Abstract »    Full Text »    PDF »
Helicobacter pylori-Induced Interleukin-12 p40 Expression.
E. Takeshima, K. Tomimori, H. Teruya, C. Ishikawa, M. Senba, D. D'Ambrosio, F. Kinjo, H. Mimuro, C. Sasakawa, T. Hirayama, et al. (2009)
Infect. Immun. 77, 1337-1348
   Abstract »    Full Text »    PDF »
Antimicrobial Activity of Curcumin against Helicobacter pylori Isolates from India and during Infections in Mice.
R. De, P. Kundu, S. Swarnakar, T. Ramamurthy, A. Chowdhury, G. B. Nair, and A. K. Mukhopadhyay (2009)
Antimicrob. Agents Chemother. 53, 1592-1597
   Abstract »    Full Text »    PDF »
Association between Chronic Atrophic Gastritis and Serum Antibodies to 15 Helicobacter pylori Proteins Measured by Multiplex Serology.
L. Gao, M. N. Weck, A. Michel, M. Pawlita, and H. Brenner (2009)
Cancer Res. 69, 2973-2980
   Abstract »    Full Text »    PDF »
Helicobacter pylori virulence and the diversity of gastric cancer in Asia.
L. T. Nguyen, T. Uchida, K. Murakami, T. Fujioka, and M. Moriyama (2008)
J. Med. Microbiol. 57, 1445-1453
   Abstract »    Full Text »    PDF »
Detection of Helicobacter pylori DNA in the saliva of patients complaining of halitosis.
N. Suzuki, M. Yoneda, T. Naito, T. Iwamoto, Y. Masuo, K. Yamada, K. Hisama, I. Okada, and T. Hirofuji (2008)
J. Med. Microbiol. 57, 1553-1559
   Abstract »    Full Text »    PDF »
Cholesterol Depletion Reduces Helicobacter pylori CagA Translocation and CagA-Induced Responses in AGS Cells.
C.-H. Lai, Y.-C. Chang, S.-Y. Du, H.-J. Wang, C.-H. Kuo, S.-H. Fang, H.-W. Fu, H.-H. Lin, A.-S. Chiang, and W.-C. Wang (2008)
Infect. Immun. 76, 3293-3303
   Abstract »    Full Text »    PDF »
A Histidine-rich and Cysteine-rich Metal-binding Domain at the C Terminus of Heat Shock Protein A from Helicobacter pylori: IMPLICATION FOR NICKEL HOMEOSTASIS AND BISMUTH SUSCEPTIBILITY.
S. Cun, H. Li, R. Ge, M. C. M. Lin, and H. Sun (2008)
J. Biol. Chem. 283, 15142-15151
   Abstract »    Full Text »    PDF »
Roles of the plasticity regions of Helicobacter pylori in gastroduodenal pathogenesis.
Y. Yamaoka (2008)
J. Med. Microbiol. 57, 545-553
   Abstract »    Full Text »    PDF »
Analysis of Helicobacter pylori isolates from Chile: occurrence of selective type 1 Lewis b antigen expression in lipopolysaccharide.
E. Altman, H. Fernandez, V. Chandan, B. A. Harrison, M. W. Schuster, L. O. Rademacher, and C. Toledo (2008)
J. Med. Microbiol. 57, 585-591
   Abstract »    Full Text »    PDF »
A new algorithm for cluster analysis of genomic methylation: the Helicobacter pylori case.
F.F. Vale, P. Encarnacao, and J. M. B. Vitor (2008)
Bioinformatics 24, 383-388
   Abstract »    Full Text »    PDF »
Helicobacter pylori Induces CCL20 Expression.
K. Tomimori, E. Uema, H. Teruya, C. Ishikawa, T. Okudaira, M. Senba, K. Yamamoto, T. Matsuyama, F. Kinjo, J. Fujita, et al. (2007)
Infect. Immun. 75, 5223-5232
   Abstract »    Full Text »    PDF »
Heterogeneity in the Activity of Mexican Helicobacter pylori Strains in Gastric Epithelial Cells and Its Association with Diversity in the cagA Gene.
A. Reyes-Leon, J. C. Atherton, R. H. Argent, J. L. Puente, and J. Torres (2007)
Infect. Immun. 75, 3445-3454
   Abstract »    Full Text »    PDF »
Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis.
S. Nagai, H. Mimuro, T. Yamada, Y. Baba, K. Moro, T. Nochi, H. Kiyono, T. Suzuki, C. Sasakawa, and S. Koyasu (2007)
PNAS 104, 8971-8976
   Abstract »    Full Text »    PDF »
Interaction between the Helicobacter pylori accessory proteins HypA and UreE is needed for urease maturation.
S. L. Benoit, N. Mehta, M. V. Weinberg, C. Maier, and R. J. Maier (2007)
Microbiology 153, 1474-1482
   Abstract »    Full Text »    PDF »
Geographical conservation of short inserts in the signal and middle regions of the Helicobacter pylori vacuolating cytotoxin gene.
R. J. Owen and J. Xerry (2007)
Microbiology 153, 1176-1186
   Abstract »    Full Text »    PDF »
Conjugative Transfer of Chromosomally Encoded Antibiotic Resistance from Helicobacter pylori to Campylobacter jejuni.
O. A. Oyarzabal, R. Rad, and S. Backert (2007)
J. Clin. Microbiol. 45, 402-408
   Abstract »    Full Text »    PDF »
A Population Genetics Pedigree Perspective on the Transmission of Helicobacter pylori.
W. Delport, M. Cunningham, B. Olivier, O. Preisig, and S. W. van der Merwe (2006)
Genetics 174, 2107-2118
   Abstract »    Full Text »    PDF »
Helicobacter pylori Induces Gastric Epithelial Cell Invasion in a c-Met and Type IV Secretion System-dependent Manner.
M. J. Oliveira, A. C. Costa, A. M. Costa, L. Henriques, G. Suriano, J. C. Atherton, J. C. Machado, F. Carneiro, R. Seruca, M. Mareel, et al. (2006)
J. Biol. Chem. 281, 34888-34896
   Abstract »    Full Text »    PDF »
Cag Pathogenicity Island-independent Up-regulation of Matrix Metalloproteinases-9 and -2 Secretion and Expression in Mice by Helicobacter pylori Infection.
P. Kundu, A. K. Mukhopadhyay, R. Patra, A. Banerjee, D. E. Berg, and S. Swarnakar (2006)
J. Biol. Chem. 281, 34651-34662
   Abstract »    Full Text »    PDF »
Protein-Protein Interactions among Helicobacter pylori Cag Proteins.
V. J. Busler, V. J. Torres, M. S. McClain, O. Tirado, D. B. Friedman, and T. L. Cover (2006)
J. Bacteriol. 188, 4787-4800
   Abstract »    Full Text »    PDF »
The Lipid A 1-Phosphatase of Helicobacter pylori Is Required for Resistance to the Antimicrobial Peptide Polymyxin..
A. X. Tran, J. D. Whittimore, P. B. Wyrick, S. C. McGrath, R. J. Cotter, and M. S. Trent (2006)
J. Bacteriol. 188, 4531-4541
   Abstract »    Full Text »    PDF »
Role of urease in megasome formation and Helicobacter pylori survival in macrophages.
J. T. Schwartz and L.-A. H. Allen (2006)
J. Leukoc. Biol. 79, 1214-1225
   Abstract »    Full Text »    PDF »
Clinical outcome of patients with Helicobacter pylori infection: the bug, the host, or the environment?.
S N Sgouros and C Bergele (2006)
Postgrad. Med. J. 82, 338-342
   Abstract »    Full Text »    PDF »
MyD88 and TNF Receptor-Associated Factor 6 Are Critical Signal Transducers in Helicobacter pylori-Infected Human Epithelial Cells.
Y. Hirata, T. Ohmae, W. Shibata, S. Maeda, K. Ogura, H. Yoshida, T. Kawabe, and M. Omata (2006)
J. Immunol. 176, 3796-3803
   Abstract »    Full Text »    PDF »
Helicobacter pylori Induces I{kappa}B Kinase {alpha} Nuclear Translocation and Chemokine Production in Gastric Epithelial Cells.
Y. Hirata, S. Maeda, T. Ohmae, W. Shibata, A. Yanai, K. Ogura, H. Yoshida, T. Kawabe, and M. Omata (2006)
Infect. Immun. 74, 1452-1461
   Abstract »    Full Text »    PDF »
Association of antibiotic resistance and higher internalization activity in resistant Helicobacter pylori isolates.
C.-H. Lai, C.-H. Kuo, P.-Y. Chen, S.-K. Poon, C.-S. Chang, and W.-C. Wang (2006)
J. Antimicrob. Chemother. 57, 466-471
   Abstract »    Full Text »    PDF »
The Cell-Specific Phenotype of the Polymorphic vacA Midregion Is Independent of the Appearance of the Cell Surface Receptor Protein Tyrosine Phosphatase {beta}.
D. A. G. Skibinski, C. Genisset, S. Barone, and J. L. Telford (2006)
Infect. Immun. 74, 49-55
   Abstract »    Full Text »    PDF »
Intrabacterial proton-dependent CagA transport system in Helicobacter pylori.
H. Wu, T. Nakano, E. Daikoku, C. Morita, T. Kohno, H. H Lian, and K. Sano (2005)
J. Med. Microbiol. 54, 1117-1125
   Abstract »    Full Text »    PDF »
Molecular characterization of the Agrobacterium tumefaciens DNA transfer protein VirB6.
P. K. Judd, D. Mahli, and A. Das (2005)
Microbiology 151, 3483-3492
   Abstract »    Full Text »    PDF »
Transmembrane glycine zippers: Physiological and pathological roles in membrane proteins.
S. Kim, T.-J. Jeon, A. Oberai, D. Yang, J. J. Schmidt, and J. U. Bowie (2005)
PNAS 102, 14278-14283
   Abstract »    Full Text »    PDF »
Spatial location and requirements for the assembly of the Agrobacterium tumefaciens type IV secretion apparatus.
P. K. Judd, R. B. Kumar, and A. Das (2005)
PNAS 102, 11498-11503
   Abstract »    Full Text »    PDF »
Analysis of Cell Type-Specific Responses Mediated by the Type IV Secretion System of Helicobacter pylori.
B. Bauer, S. Moese, S. Bartfeld, T. F. Meyer, and M. Selbach (2005)
Infect. Immun. 73, 4643-4652
   Abstract »    Full Text »    PDF »
Distinct Diversity of vacA, cagA, and cagE Genes of Helicobacter pylori Associated with Peptic Ulcer in Japan.
S. Yamazaki, A. Yamakawa, T. Okuda, M. Ohtani, H. Suto, Y. Ito, Y. Yamazaki, Y. Keida, H. Higashi, M. Hatakeyama, et al. (2005)
J. Clin. Microbiol. 43, 3906-3916
   Abstract »    Full Text »    PDF »
Introduction: What Should We Do Now about H. pylori?.
E. R. Greenberg, D. S. Alberts, and J. D. Potter (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 1851-1852
   Full Text »    PDF »
Role of Cytokine Polymorphisms in the Risk of Distal Gastric Cancer Development.
G. I. Perez-Perez, E. Garza-Gonzalez, C. Portal, and A. Z. Olivares (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 1869-1873
   Abstract »    Full Text »    PDF »
The Development of Therapeutic and Preventive Vaccines for Gastric Cancer and Helicobacter pylori.
S. Y. Chui, T. M. Clay, H. K. Lyerly, and M. A. Morse (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 1883-1889
   Abstract »    Full Text »    PDF »
Impact of Helicobacter pylori Virulence Factors and Compounds on Activation and Maturation of Human Dendritic Cells.
K. Kranzer, L. Sollner, M. Aigner, N. Lehn, L. Deml, M. Rehli, and W. Schneider-Brachert (2005)
Infect. Immun. 73, 4180-4189
   Abstract »    Full Text »    PDF »
Phosphoinositide3-kinase regulates actin polymerization during delayed phagocytosis of Helicobacter pylori.
L.-A. H. Allen, J. A. Allgood, X. Han, and L. M. Wittine (2005)
J. Leukoc. Biol. 78, 220-230
   Abstract »    Full Text »    PDF »
NF-{kappa}B activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein.
S. Brandt, T. Kwok, R. Hartig, W. Konig, and S. Backert (2005)
PNAS 102, 9300-9305
   Abstract »    Full Text »    PDF »
EPIYA Motif Is a Membrane-targeting Signal of Helicobacter pylori Virulence Factor CagA in Mammalian Cells.
H. Higashi, K. Yokoyama, Y. Fujii, S. Ren, H. Yuasa, I. Saadat, N. Murata-Kamiya, T. Azuma, and M. Hatakeyama (2005)
J. Biol. Chem. 280, 23130-23137
   Abstract »    Full Text »    PDF »
Roles of virD4 and cagG genes in the cag pathogenicity island of Helicobacter pylori using a Mongolian gerbil model.
H Saito, Y Yamaoka, S Ishizone, F Maruta, A Sugiyama, D Y Graham, K Yamauchi, H Ota, and S Miyagawa (2005)
Gut 54, 584-590
   Abstract »    Full Text »    PDF »
Identification of New Protein-Protein Interactions Involving the Products of the Chromosome- and Plasmid-Encoded Type IV Secretion Loci of the Phytopathogen Xanthomonas axonopodis pv. citri.
M. C. Alegria, D. P. Souza, M. O. Andrade, C. Docena, L. Khater, C. H. I. Ramos, A. C. R. da Silva, and C. S. Farah (2005)
J. Bacteriol. 187, 2315-2325
   Abstract »    Full Text »    PDF »
Mutational Analysis of Metronidazole Resistance in Helicobacter pylori.
J. M. Moore and N. R. Salama (2005)
Antimicrob. Agents Chemother. 49, 1236-1237
   Abstract »    Full Text »    PDF »
Helicobacter pylori Induces Interleukin-8 Secretion by Toll-Like Receptor 2- and Toll-Like Receptor 5-Dependent and -Independent Pathways.
A. M. Torok, A. H. Bouton, and J. B. Goldberg (2005)
Infect. Immun. 73, 1523-1531
   Abstract »    Full Text »    PDF »
Helicobacter pylori Induces Transendothelial Migration of Activated Memory T Cells.
K. Enarsson, M. Brisslert, S. Backert, and M. Quiding-Jarbrink (2005)
Infect. Immun. 73, 761-769
   Abstract »    Full Text »    PDF »
Chemotaxis Plays Multiple Roles during Helicobacter pylori Animal Infection.
K. Terry, S. M. Williams, L. Connolly, and K. M. Ottemann (2005)
Infect. Immun. 73, 803-811
   Abstract »    Full Text »    PDF »
Use of the Restriction Enzyme EcoRI for Pulsed-Field Gel Electrophoretic Analysis of Helicobacter pylori.
Y. Hosaka, K. Irinoda, R. Nakano, S. Tanabe, W. Koizumi, K. Saigenji, and M. Inoue (2005)
J. Clin. Microbiol. 43, 931-932
   Abstract »    Full Text »    PDF »
Global Transposon Mutagenesis and Essential Gene Analysis of Helicobacter pylori.
N. R. Salama, B. Shepherd, and S. Falkow (2004)
J. Bacteriol. 186, 7926-7935
   Abstract »    Full Text »    PDF »
Helicobacter pylori heat-shock protein 60 induces inflammatory responses through the Toll-like receptor-triggered pathway in cultured human gastric epithelial cells.
R. Takenaka, K. Yokota, K. Ayada, M. Mizuno, Y. Zhao, Y. Fujinami, S.-N. Lin, T. Toyokawa, H. Okada, Y. Shiratori, et al. (2004)
Microbiology 150, 3913-3922
   Abstract »    Full Text »    PDF »
The cag Pathogenicity Island of Helicobacter pylori Is Disrupted in the Majority of Patient Isolates from Different Human Populations.
F. Kauser, A. A. Khan, M. A. Hussain, I. M. Carroll, N. Ahmad, S. Tiwari, Y. Shouche, B. Das, M. Alam, S. M. Ali, et al. (2004)
J. Clin. Microbiol. 42, 5302-5308
   Abstract »    Full Text »    PDF »
Nucleotide sequences and comparison of two large conjugative plasmids from different Campylobacter species.
R. A. Batchelor, B. M. Pearson, L. M. Friis, P. Guerry, and J. M. Wells (2004)
Microbiology 150, 3507-3517
   Abstract »    Full Text »    PDF »
Tra Proteins Characteristic of F-Like Type IV Secretion Systems Constitute an Interaction Group by Yeast Two-Hybrid Analysis.
R. L. Harris and P. M. Silverman (2004)
J. Bacteriol. 186, 5480-5485
   Abstract »    Full Text »    PDF »
Induction of Maturation and Cytokine Release of Human Dendritic Cells by Helicobacter pylori.
K. Kranzer, A. Eckhardt, M. Aigner, G. Knoll, L. Deml, C. Speth, N. Lehn, M. Rehli, and W. Schneider-Brachert (2004)
Infect. Immun. 72, 4416-4423
   Abstract »    Full Text »    PDF »
Alanine-Threonine Polymorphism of Helicobacter pylori RpoB Is Correlated with Differential Induction of Interleukin-8 in MKN45 Cells.
K.-H. Lee, M.-J. Cho, Y. Yamaoka, D. Y. Graham, Y.-J. Yun, S.-Y. Woo, C.-Y. Lim, K.-S. Ko, B.-J. Kim, H.-C. Jung, et al. (2004)
J. Clin. Microbiol. 42, 3518-3524
   Abstract »    Full Text »    PDF »
Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection.
R Rad, A Dossumbekova, B Neu, R Lang, S Bauer, D Saur, M Gerhard, and C Prinz (2004)
Gut 53, 1082-1089
   Abstract »    Full Text »    PDF »
Distinct Diversity of the cag Pathogenicity Island among Helicobacter pylori Strains in Japan.
T. Azuma, A. Yamakawa, S. Yamazaki, M. Ohtani, Y. Ito, A. Muramatsu, H. Suto, Y. Yamazaki, Y. Keida, H. Higashi, et al. (2004)
J. Clin. Microbiol. 42, 2508-2517
   Abstract »    Full Text »    PDF »
Helicobacter pylori Induces Apoptosis of Macrophages in Association with Alterations in the Mitochondrial Pathway.
R. J. Menaker, P. J. M. Ceponis, and N. L. Jones (2004)
Infect. Immun. 72, 2889-2898
   Abstract »    Full Text »    PDF »
Helicobacter pylori CagA Induces Ras-independent Morphogenetic Response through SHP-2 Recruitment and Activation.
H. Higashi, A. Nakaya, R. Tsutsumi, K. Yokoyama, Y. Fujii, S. Ishikawa, M. Higuchi, A. Takahashi, Y. Kurashima, Y. Teishikata, et al. (2004)
J. Biol. Chem. 279, 17205-17216
   Abstract »    Full Text »    PDF »
Membrane channel structure of Helicobacter pylori vacuolating toxin: Role of multiple GXXXG motifs in cylindrical channels.
S. Kim, A. K. Chamberlain, and J. U. Bowie (2004)
PNAS 101, 5988-5991
   Abstract »    Full Text »    PDF »
Unveiling Molecular Scaffolds of the Type IV Secretion System.
H.-J. Yeo and G. Waksman (2004)
J. Bacteriol. 186, 1919-1926
   Full Text »    PDF »
Analysis of Helicobacter pylori Genotypes and Correlation with Clinical Outcome in Turkey.
H. Saribasak, B. A. Salih, Y. Yamaoka, and E. Sander (2004)
J. Clin. Microbiol. 42, 1648-1651
   Abstract »    Full Text »    PDF »
VirB1 Orthologs from Brucella suis and pKM101 Complement Defects of the Lytic Transglycosylase Required for Efficient Type IV Secretion from Agrobacterium tumefaciens.
C. Hoppner, Z. Liu, N. Domke, A. N. Binns, and C. Baron (2004)
J. Bacteriol. 186, 1415-1422
   Abstract »    Full Text »    PDF »
Functional Analysis of the cag Pathogenicity Island in Helicobacter pylori Isolates from Patients with Gastritis, Peptic Ulcer, and Gastric Cancer.
S. Backert, T. Schwarz, S. Miehlke, C. Kirsch, C. Sommer, T. Kwok, M. Gerhard, U. B. Goebel, N. Lehn, W. Koenig, et al. (2004)
Infect. Immun. 72, 1043-1056
   Abstract »    Full Text »    PDF »
Analysis of geospecific markers for Helicobacter pylori variants in patients from Japan and Nigeria by triple-locus nucleotide sequence typing.
R. J. Owen, J. Xerry, T. Gotada, G. Naylor, and D. Tompkins (2004)
Microbiology 150, 151-161
   Abstract »    Full Text »    PDF »
Correlation between cag Pathogenicity Island Composition and Helicobacter pylori-Associated Gastroduodenal Disease.
C. Nilsson, A. Sillen, L. Eriksson, M.-L. Strand, H. Enroth, S. Normark, P. Falk, and L. Engstrand (2003)
Infect. Immun. 71, 6573-6581
   Abstract »    Full Text »    PDF »
Helicobacter pylori cag Pathogenicity Island Is Associated with Reduced Expression of Interleukin-4 (IL-4) mRNA and Modulation of the IL-4{delta}2 mRNA Isoform in Human Gastric Mucosa.
B. Orsini, B. Ottanelli, A. Amedei, E. Surrenti, M. Capanni, G. Del Prete, A. Amorosi, S. Milani, M. M. D'Elios, and C. Surrenti (2003)
Infect. Immun. 71, 6664-6667
   Abstract »    Full Text »    PDF »
Occurrence of a nontypable Helicobacter pylori strain lacking Lewis blood group O antigens and DD-heptoglycan: evidence for the role of the core {alpha}1,6-glucan chain in colonization.
E. Altman, N. Smirnova, J. Li, A. Aubry, and S. M. Logan (2003)
Glycobiology 13, 777-783
   Abstract »    Full Text »    PDF »
Complete genome sequence and analysis of Wolinella succinogenes.
C. Baar, M. Eppinger, G. Raddatz, J. Simon, C. Lanz, O. Klimmek, R. Nandakumar, R. Gross, A. Rosinus, H. Keller, et al. (2003)
PNAS 100, 11690-11695
   Abstract »    Full Text »    PDF »
Virulence Genes and Neutral DNA Markers of Helicobacter pylori Isolates from Different Ethnic Communities of West Bengal, India.
S. Datta, S. Chattopadhyay, G. Balakrish Nair, A. K. Mukhopadhyay, J. Hembram, D. E. Berg, D. Rani Saha, A. Khan, A. Santra, S. K. Bhattacharya, et al. (2003)
J. Clin. Microbiol. 41, 3737-3743
   Abstract »    Full Text »    PDF »
Tooth loss, pancreatic cancer, and Helicobacter pylori.
R. Z Stolzenberg-Solomon, K. W Dodd, M. J Blaser, J. Virtamo, P. R Taylor, and D. Albanes (2003)
Am. J. Clinical Nutrition 78, 176-181
   Abstract »    Full Text »    PDF »
Antigenic Properties of HpaA and Omp18, Two Outer Membrane Proteins of Helicobacter pylori.
P. Voland, N. Hafsi, M. Zeitner, S. Laforsch, H. Wagner, and C. Prinz (2003)
Infect. Immun. 71, 3837-3843
   Abstract »    Full Text »    PDF »
pH-Regulated Gene Expression of the Gastric Pathogen Helicobacter pylori.
D. S. Merrell, M. L. Goodrich, G. Otto, L. S. Tompkins, and S. Falkow (2003)
Infect. Immun. 71, 3529-3539
   Abstract »    Full Text »    PDF »
Conjugative Plasmid Transfer in Gram-Positive Bacteria.
E. Grohmann, G. Muth, and M. Espinosa (2003)
Microbiol. Mol. Biol. Rev. 67, 277-301
   Abstract »    Full Text »    PDF »
Development of an Interleukin-12-Deficient Mouse Model That Is Permissive for Colonization by a Motile KE26695 Strain of Helicobacter pylori.
P. S. Hoffman, N. Vats, D. Hutchison, J. Butler, K. Chisholm, G. Sisson, A. Raudonikiene, J. S. Marshall, and S. J. O. Veldhuyzen van Zanten (2003)
Infect. Immun. 71, 2534-2541
   Abstract »    Full Text »    PDF »
Agrobacterium tumefaciens VirB6 Protein Participates in Formation of VirB7 and VirB9 Complexes Required for Type IV Secretion.
S. J. Jakubowski, V. Krishnamoorthy, and P. J. Christie (2003)
J. Bacteriol. 185, 2867-2878
   Abstract »    Full Text »    PDF »
Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response.
Y. Churin, L. Al-Ghoul, O. Kepp, T. F. Meyer, W. Birchmeier, and M. Naumann (2003)
J. Cell Biol. 161, 249-255
   Abstract »    Full Text »    PDF »
Type III secretion systems and bacterial flagella: Insights into their function from structural similarities.
A. Blocker, K. Komoriya, and S.-I. Aizawa (2003)
PNAS 100, 3027-3030
   Abstract »    Full Text »    PDF »
Traces of Human Migrations in Helicobacter pylori Populations.
D. Falush, T. Wirth, B. Linz, J. K. Pritchard, M. Stephens, M. Kidd, M. J. Blaser, D. Y. Graham, S. Vacher, G. I. Perez-Perez, et al. (2003)
Science 299, 1582-1585
   Abstract »    Full Text »    PDF »
Production of the Type IV Secretion System Differs among Brucella Species as Revealed with VirB5- and VirB8-Specific Antisera.
B. Rouot, M.-T. Alvarez-Martinez, C. Marius, P. Menanteau, L. Guilloteau, R.-A. Boigegrain, R. Zumbihl, D. O'Callaghan, N. Domke, and C. Baron (2003)
Infect. Immun. 71, 1075-1082
   Abstract »    Full Text »    PDF »
Helicobacter Pylori Infection and Gastric Cancer.
P. Correa (2003)
Cancer Epidemiol. Biomarkers Prev. 12, 238s-241s
   Full Text »    PDF »
Up-regulated Smad5 Mediates Apoptosis of Gastric Epithelial Cells Induced by Helicobacter pylori Infection.
T. Nagasako, T. Sugiyama, T. Mizushima, Y. Miura, M. Kato, and M. Asaka (2003)
J. Biol. Chem. 278, 4821-4825
   Abstract »    Full Text »    PDF »
Helicobacter pylori genotyping in gastric adenocarcinoma and MALT lymphoma by multiplex PCR analyses of paraffin wax embedded tissues.
C I Koehler, M B Mues, H P Dienes, J Kriegsmann, P Schirmacher, and M Odenthal (2003)
Mol. Pathol. 56, 36-42
   Abstract »    Full Text »    PDF »
Attenuation of Helicobacter pylori CagA{middle dot}SHP-2 Signaling by Interaction between CagA and C-terminal Src Kinase.
R. Tsutsumi, H. Higashi, M. Higuchi, M. Okada, and M. Hatakeyama (2003)
J. Biol. Chem. 278, 3664-3670
   Abstract »    Full Text »    PDF »
Interactions among the seven Helicobacter pylori proteins encoded by the urease gene cluster.
P. Voland, D. L. Weeks, E. A. Marcus, C. Prinz, G. Sachs, and D. Scott (2003)
Am J Physiol Gastrointest Liver Physiol 284, G96-G106
   Abstract »    Full Text »    PDF »
Proteins Released by Helicobacter pylori In Vitro.
N. Kim, D. L. Weeks, J. M. Shin, D. R. Scott, M. K. Young, and G. Sachs (2002)
J. Bacteriol. 184, 6155-6162
   Abstract »    Full Text »    PDF »
DNA Sequence and Mutational Analyses of the pVir Plasmid of Campylobacter jejuni 81-176.
D. J. Bacon, R. A. Alm, L. Hu, T. E. Hickey, C. P. Ewing, R. A. Batchelor, T. J. Trust, and P. Guerry (2002)
Infect. Immun. 70, 6242-6250
   Abstract »    Full Text »    PDF »
Secretion of {alpha}-Amylase from Pseudoalteromonas haloplanktis TAB23: Two Different Pathways in Different Hosts.
M. L. Tutino, E. Parrilli, L. Giaquinto, A. Duilio, G. Sannia, G. Feller, and G. Marino (2002)
J. Bacteriol. 184, 5814-5817
   Abstract »    Full Text »    PDF »
Two Predicted Chemoreceptors of Helicobacter pylori Promote Stomach Infection.
T. M. Andermann, Y.-T. Chen, and K. M. Ottemann (2002)
Infect. Immun. 70, 5877-5881
   Abstract »    Full Text »    PDF »
Detergent extraction identifies different VirB protein subassemblies of the type IV secretion machinery in the membranes of Agrobacteriumtumefaciens.
L. Krall, U. Wiedemann, G. Unsin, S. Weiss, N. Domke, and C. Baron (2002)
PNAS 99, 11405-11410
   Abstract »    Full Text »    PDF »
Helicobacter pylori induces apoptosis of rat gastric parietal cells.
B. Neu, P. Randlkofer, M. Neuhofer, P. Voland, A. Mayerhofer, M. Gerhard, W. Schepp, and C. Prinz (2002)
Am J Physiol Gastrointest Liver Physiol 283, G309-G318
   Abstract »    Full Text »    PDF »
Identification of Surface Proteins of Helicobacter pylori by Selective Biotinylation, Affinity Purification, and Two-dimensional Gel Electrophoresis.
N. Sabarth, S. Lamer, U. Zimny-Arndt, P. R. Jungblut, T. F. Meyer, and D. Bumann (2002)
J. Biol. Chem. 277, 27896-27902
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)