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Science 14 May 1999:
Vol. 284. no. 5417, pp. 1168 - 1170
DOI: 10.1126/science.284.5417.1168
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Reports

Bone Marrow as a Potential Source of Hepatic Oval Cells

B. E. Petersen, 1* W. C. Bowen, 1 K. D. Patrene, 2 W. M. Mars, 1 A. K. Sullivan, 4dagger N. Murase, 3 S. S. Boggs, 2 J. S. Greenberger, 2 J. P. Goff 2

Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.

1 Department of Pathology,
2 Department of Radiation Oncology,
3 Division of Transplant Pathology, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
4 Department of Hematology/Oncology, McGill University, Quebec H3A 2T5, Canada.
*   To whom correspondence should be addressed. E-mail: bryon+@pitt.edu

dagger    Present address: Department of Oncology, King Faisal Specialist Hospital and Research Centre, Post Office Box 3354, Riyadh, Kingdom of Saudi Arabia.

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Human Pulmonary Chimerism after Hematopoietic Stem Cell Transplantation.
B. T. Suratt, C. D. Cool, A. E. Serls, L. Chen, M. Varella-Garcia, E. J. Shpall, K. K. Brown, and G. S. Worthen (2003)
Am. J. Respir. Crit. Care Med. 168, 318-322
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An Overview of Stem Cell Research and Regulatory Issues.
C. R. Cogle, S. M. Guthrie, R. C. Sanders, W. L. Allen, E. W. Scott, and B. E. Petersen (2003)
Mayo Clin. Proc. 78, 993-1003
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Stem Cell Research: Elephants in the Room.
N. D. Theise (2003)
Mayo Clin. Proc. 78, 1004-1009
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Adult Cardiac Stem Cells--Where Do We Go from Here?.
J. M. Edelberg, M. Xaymardan, S. Rafii, and M. K. Hong (2003)
Sci. Aging Knowl. Environ. 2003, pe17-17
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Transcoronary implantation of bone marrow stromal cells ameliorates cardiac function after myocardial infarction.
T. Saito, J.-Q. Kuang, C. C. H. Lin, and R. C.-J. Chiu (2003)
J. Thorac. Cardiovasc. Surg. 126, 114-122
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Adult Stem Cell Plasticity Defined.
J. C. Howell and M. C. Yoder (2003)
NeoReviews 4, e181-186
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Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells.
X. Wang, S. Ge, G. McNamara, Q.-L. Hao, G. M. Crooks, and J. A. Nolta (2003)
Blood 101, 4201-4208
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SHED: Stem cells from human exfoliated deciduous teeth.
M. Miura, S. Gronthos, M. Zhao, B. Lu, L. W. Fisher, P. G. Robey, and S. Shi (2003)
PNAS 100, 5807-5812
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Hematopoietic stem cells: can old cells learn new tricks?.
A. D. Ho and M. Punzel (2003)
J. Leukoc. Biol. 73, 547-555
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Isolation of hepatoblasts based on the expression of Dlk/Pref-1.
N. Tanimizu, M. Nishikawa, H. Saito, T. Tsujimura, and A. Miyajima (2003)
J. Cell Sci. 116, 1775-1786
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Increased Chimerism of Bronchial and Alveolar Epithelium in Human Lung Allografts Undergoing Chronic Injury.
W. Kleeberger, A. Versmold, T. Rothamel, S. Glockner, M. Bredt, A. Haverich, U. Lehmann, and H. Kreipe (2003)
Am. J. Pathol. 162, 1487-1494
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Origin and use of embryonic and adult stem cells in differentiation and tissue repair.
R. Passier and C. Mummery (2003)
Cardiovasc Res 58, 324-335
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Vascular gene delivery of anticoagulants by transplantation of retrovirally-transduced endothelial progenitor cells.
D. P. Griese, S. Achatz, C. A. Batzlsperger, U. G. Strauch, B. Grumbeck, J. Weil, and G. A.J. Riegger (2003)
Cardiovasc Res 58, 469-477
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Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide.
M. Krampera, S. Glennie, J. Dyson, D. Scott, R. Laylor, E. Simpson, and F. Dazzi (2003)
Blood 101, 3722-3729
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Fetal liver stroma consists of cells in epithelial-to-mesenchymal transition.
J. Chagraoui, A. Lepage-Noll, A. Anjo, G. Uzan, and P. Charbord (2003)
Blood 101, 2973-2982
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Neural Stem Cells: An Overview.
R. Galli, A. Gritti, L. Bonfanti, and A. L. Vescovi (2003)
Circ. Res. 92, 598-608
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Cellular origins of atherosclerosis: towards ontogenetic endgame?.
T. M. DOHERTY, P. K. SHAH, and T. B. RAJAVASHISTH (2003)
FASEB J 17, 592-597
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