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Science 30 April 1999:
Vol. 284. no. 5415, pp. 819 - 822
DOI: 10.1126/science.284.5415.819
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Reports

Chemokine Up-Regulation and Activated T Cell Attraction by Maturing Dendritic Cells

H. Lucy Tang, Jason G. Cyster *

Langerhans' cells migrating from contact-sensitized skin were found to up-regulate expression of macrophage-derived chemokine (MDC) during maturation into lymph node dendritic cells (DCs). Naïve T cells did not migrate toward MDC, but antigen-specific T cells rapidly acquired MDC responsiveness in vivo after a subcutaneous injection of antigen. In chemotaxis assays, maturing DCs attracted activated T cells more strongly than naïve T cells. These studies identified chemokine up-regulation as part of the Langerhans' cell maturation program to immunogenic T cell-zone DC. Preferential recruitment of activated T cells may be a mechanism used by maturing DCs to promote encounters with antigen-specific T cells.

Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA.
*   To whom correspondence should be addressed. E-mail: cyster{at}itsa.ucsf.edu

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