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Science 30 April 1999:
Vol. 284. no. 5415, pp. 770 - 776
DOI: 10.1126/science.284.5415.770
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Review

Notch Signaling: Cell Fate Control and Signal Integration in Development

Spyros Artavanis-Tsakonas, * Matthew D. Rand, Robert J. Lake

Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, Notch signals control how cells respond to intrinsic or extrinsic developmental cues that are necessary to unfold specific developmental programs. Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis.

Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
*   To whom correspondence should be addressed.

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Joint Estimates of Quantitative Trait Locus Effect and Frequency Using Synthetic Recombinant Populations of Drosophila melanogaster.
S. J. Macdonald and A. D. Long (2007)
Genetics 176, 1261-1281
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Stra13 regulates satellite cell activation by antagonizing Notch signaling.
H. Sun, L. Li, C. Vercherat, N. T. Gulbagci, S. Acharjee, J. Li, T.-K. Chung, T. H. Thin, and R. Taneja (2007)
J. Cell Biol. 177, 647-657
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