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Science 30 April 1999:
Vol. 284. no. 5415, pp. 770 - 776
DOI: 10.1126/science.284.5415.770
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Review

Notch Signaling: Cell Fate Control and Signal Integration in Development

Spyros Artavanis-Tsakonas, * Matthew D. Rand, Robert J. Lake

Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, Notch signals control how cells respond to intrinsic or extrinsic developmental cues that are necessary to unfold specific developmental programs. Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis.

Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
*   To whom correspondence should be addressed.

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Cold Spring Harb Symp Quant Biol
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N. Fukazawa, S. Yokoyama, M. Eiraku, M. Kengaku, and N. Maeda (2008)
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Y. Moriyama, C. Sekine, A. Koyanagi, N. Koyama, H. Ogata, S. Chiba, S. Hirose, K. Okumura, and H. Yagita (2008)
Int. Immunol. 20, 763-773
   Abstract »    Full Text »    PDF »
RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex.
D. R. Friedmann, J. J. Wilson, and R. A. Kovall (2008)
J. Biol. Chem. 283, 14781-14791
   Abstract »    Full Text »    PDF »
Notch Signaling in Cardiac Development.
K. Niessen and A. Karsan (2008)
Circ. Res. 102, 1169-1181
   Abstract »    Full Text »    PDF »
ETO, but Not Leukemogenic Fusion Protein AML1/ETO, Augments RBP-J{kappa}/SHARP-Mediated Repression of Notch Target Genes.
D. Salat, R. Liefke, J. Wiedenmann, T. Borggrefe, and F. Oswald (2008)
Mol. Cell. Biol. 28, 3502-3512
   Abstract »    Full Text »    PDF »
Critical Role of Notch Signaling in Osteosarcoma Invasion and Metastasis.
P. Zhang, Y. Yang, P. A. Zweidler-McKay, and D. P.M. Hughes (2008)
Clin. Cancer Res. 14, 2962-2969
   Abstract »    Full Text »    PDF »


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