Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Science Policy Alerts

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 30 April 1999:
Vol. 284. no. 5415, pp. 770 - 776
DOI: 10.1126/science.284.5415.770

Review

Notch Signaling: Cell Fate Control and Signal Integration in Development

Spyros Artavanis-Tsakonas, * Matthew D. Rand, Robert J. Lake

Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, Notch signals control how cells respond to intrinsic or extrinsic developmental cues that are necessary to unfold specific developmental programs. Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis.

Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
*   To whom correspondence should be addressed.


Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Activated Notch1 Receptor Cooperates with {alpha}-Enolase and MBP-1 in Modulating c-myc Activity.
K.-W. Hsu, R.-H. Hsieh, Y.-H. W. Lee, C.-H. Chao, K.-J. Wu, M.-J. Tseng, and T.-S. Yeh (2008)
Mol. Cell. Biol. 28, 4829-4842
   Abstract »    Full Text »    PDF »
Mind bomb-1 Is Essential for Intraembryonic Hematopoiesis in the Aortic Endothelium and the Subaortic Patches.
M.-J. Yoon, B.-K. Koo, R. Song, H.-W. Jeong, J. Shin, Y.-W. Kim, Y.-Y. Kong, and P.-G. Suh (2008)
Mol. Cell. Biol. 28, 4794-4804
   Abstract »    Full Text »    PDF »
Notch Inhibits Osteoblast Differentiation and Causes Osteopenia.
S. Zanotti, A. Smerdel-Ramoya, L. Stadmeyer, D. Durant, F. Radtke, and E. Canalis (2008)
Endocrinology 149, 3890-3899
   Abstract »    Full Text »    PDF »
ADAM10 is essential for proteolytic activation of Notch during thymocyte development.
L. Tian, X. Wu, C. Chi, M. Han, T. Xu, and Y. Zhuang (2008)
Int. Immunol.
   Abstract »    Full Text »    PDF »
Receptor Type Protein Tyrosine Phosphatase {zeta}-Pleiotrophin Signaling Controls Endocytic Trafficking of DNER That Regulates Neuritogenesis.
N. Fukazawa, S. Yokoyama, M. Eiraku, M. Kengaku, and N. Maeda (2008)
Mol. Cell. Biol. 28, 4494-4506
   Abstract »    Full Text »    PDF »
LvNumb works synergistically with Notch signaling to specify non-skeletal mesoderm cells in the sea urchin embryo.
R. C. Range, T. D. Glenn, E. Miranda, and D. R. McClay (2008)
Development 135, 2445-2454
   Abstract »    Full Text »    PDF »
Ethanol stimulates endothelial cell angiogenic activity via a Notch- and angiopoietin-1-dependent pathway.
D. Morrow, J. P. Cullen, P. A. Cahill, and E. M. Redmond (2008)
Cardiovasc Res 79, 313-321
   Abstract »    Full Text »    PDF »
Biological Functions of Glycosyltransferase Genes Involved in O-fucose Glycan Synthesis.
T. Okajima, A. Matsuura, and T. Matsuda (2008)
J. Biochem. 144, 1-6
   Abstract »    Full Text »    PDF »
Methylmercury Activates Enhancer-of-Split and Bearded Complex Genes Independent of the Notch Receptor.
M. D. Rand, C. E. Bland, and J. Bond (2008)
Toxicol. Sci. 104, 163-176
   Abstract »    Full Text »    PDF »
NOTCH2 mutations in marginal zone lymphoma.
G. Troen, I. Wlodarska, A. Warsame, S. Hernandez Llodra, C. De Wolf-Peeters, and J. Delabie (2008)
Haematologica 93, 1107-1109
   Full Text »    PDF »
Cancer Stem Cells and the Ontogeny of Lung Cancer.
C. D. Peacock and D. N. Watkins (2008)
J. Clin. Oncol. 26, 2883-2889
   Abstract »    Full Text »    PDF »
Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice.
Y. Moriyama, C. Sekine, A. Koyanagi, N. Koyama, H. Ogata, S. Chiba, S. Hirose, K. Okumura, and H. Yagita (2008)
Int. Immunol. 20, 763-773
   Abstract »    Full Text »    PDF »
RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex.
D. R. Friedmann, J. J. Wilson, and R. A. Kovall (2008)
J. Biol. Chem. 283, 14781-14791
   Abstract »    Full Text »    PDF »
Notch Signaling in Cardiac Development.
K. Niessen and A. Karsan (2008)
Circ. Res. 102, 1169-1181
   Abstract »    Full Text »    PDF »
ETO, but Not Leukemogenic Fusion Protein AML1/ETO, Augments RBP-J{kappa}/SHARP-Mediated Repression of Notch Target Genes.
D. Salat, R. Liefke, J. Wiedenmann, T. Borggrefe, and F. Oswald (2008)
Mol. Cell. Biol. 28, 3502-3512
   Abstract »    Full Text »    PDF »
Critical Role of Notch Signaling in Osteosarcoma Invasion and Metastasis.
P. Zhang, Y. Yang, P. A. Zweidler-McKay, and D. P.M. Hughes (2008)
Clin. Cancer Res. 14, 2962-2969
   Abstract »    Full Text »    PDF »
Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation.
M. Okamoto, K. Takeda, A. Joetham, H. Ohnishi, H. Matsuda, C. H. Swasey, B. J. Swanson, K. Yasutomo, A. Dakhama, and E. W. Gelfand (2008)
J. Exp. Med. 205, 1087-1097
   Abstract »    Full Text »    PDF »
Activation of Notch-Mediated Protective Signaling in the Myocardium.
N. A. Gude, G. Emmanuel, W. Wu, C. T. Cottage, K. Fischer, P. Quijada, J. A. Muraski, R. Alvarez, M. Rubio, E. Schaefer, et al. (2008)
Circ. Res. 102, 1025-1035
   Abstract »    Full Text »    PDF »
Current Management of Medullary Thyroid Cancer.
R. S. Sippel, M. Kunnimalaiyaan, and H. Chen (2008)
Oncologist 13, 539-547
   Abstract »    Full Text »    PDF »
Hes1 Regulates Corneal Development and the Function of Corneal Epithelial Stem/Progenitor Cells.
T. Nakamura, T. Ohtsuka, E. Sekiyama, L. J. Cooper, H. Kokubu, N. J. Fullwood, Y. Barrandon, R. Kageyama, and S. Kinoshita (2008)
Stem Cells 26, 1265-1274
   Abstract »    Full Text »    PDF »
Localization of the Delta-like-1-binding Site in Human Notch-1 and Its Modulation by Calcium Affinity.
J. Cordle, C. RedfieldZ, M. Stacey, P. A. van der Merwe, A. C. Willis, B. R. Champion, S. Hambleton, and P. A. Handford (2008)
J. Biol. Chem. 283, 11785-11793
   Abstract »    Full Text »    PDF »
Linking Notch signaling to ischemic stroke.
J. F. Arboleda-Velasquez, Z. Zhou, H. K. Shin, A. Louvi, H.-H. Kim, S. I. Savitz, J. K. Liao, S. Salomone, C. Ayata, M. A. Moskowitz, et al. (2008)
PNAS 105, 4856-4861
   Abstract »    Full Text »    PDF »
Regulation of Lymphocyte Development by Cell-Type-Specific Interpretation of Notch Signals.
L. Nie, S. S. Perry, Y. Zhao, J. Huang, P. W. Kincade, M. A. Farrar, and X.-H. Sun (2008)
Mol. Cell. Biol. 28, 2078-2090
   Abstract »    Full Text »    PDF »
Defining Pancreatic Endocrine Precursors and Their Descendants.
P. White, C. Lee May, R. N. Lamounier, J. E. Brestelli, and K. H. Kaestner (2008)
Diabetes 57, 654-668
   Abstract »    Full Text »    PDF »
Distinct Effects of the Soluble Versus Membrane-Bound Forms of the Notch Ligand Delta-4 on Human CD34+CD38low Cell Expansion and Differentiation.
M. Lahmar, C. Catelain, S. Poirault, M. Dorsch, J.-L. Villeval, W. Vainchenker, O. Albagli, and E. Lauret (2008)
Stem Cells 26, 621-629
   Abstract »    Full Text »    PDF »
Notch Signaling Through Jagged-1 Is Necessary to Initiate Chondrogenesis in Human Bone Marrow Stromal Cells but Must Be Switched off to Complete Chondrogenesis.
R. A. Oldershaw, S. R. Tew, A. M. Russell, K. Meade, R. Hawkins, T. R. McKay, K. R. Brennan, and T. E. Hardingham (2008)
Stem Cells 26, 666-674
   Abstract »    Full Text »    PDF »
Ageing-exaggerated proliferation of vascular smooth muscle cells is related to attenuation of Jagged1 expression in endothelial cells.
X. Wu, Q. Zhou, L. Huang, A. Sun, K. Wang, Y. Zou, and J. Ge (2008)
Cardiovasc Res 77, 800-808
   Abstract »    Full Text »    PDF »
Mastermind-like Domain-containing 1 (MAMLD1 or CXorf6) Transactivates the Hes3 Promoter, Augments Testosterone Production, and Contains the SF1 Target Sequence.
M. Fukami, Y. Wada, M. Okada, F. Kato, N. Katsumata, T. Baba, K.-i. Morohashi, J. Laporte, M. Kitagawa, and T. Ogata (2008)
J. Biol. Chem. 283, 5525-5532
   Abstract »    Full Text »    PDF »
Endosomal entry regulates Notch receptor activation in Drosophila melanogaster.
T. Vaccari, H. Lu, R. Kanwar, M. E. Fortini, and D. Bilder (2008)
J. Cell Biol. 180, 755-762
   Abstract »    Full Text »    PDF »
Neuralized-like 1 (Neurl1) Targeted to the Plasma Membrane by N-Myristoylation Regulates the Notch Ligand Jagged1.
E. Koutelou, S. Sato, C. Tomomori-Sato, L. Florens, S. K. Swanson, M. P. Washburn, M. Kokkinaki, R. C. Conaway, J. W. Conaway, and N. K. Moschonas (2008)
J. Biol. Chem. 283, 3846-3853
   Abstract »    Full Text »    PDF »
Notch3 Inhibition in Myelin-Reactive T Cells Down-Regulates Protein Kinase C{theta} and Attenuates Experimental Autoimmune Encephalomyelitis.
M. Jurynczyk, A. Jurewicz, C. S. Raine, and K. Selmaj (2008)
J. Immunol. 180, 2634-2640
   Abstract »    Full Text »    PDF »
Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy.
Y. Nefedova, D. M. Sullivan, S. C. Bolick, W. S. Dalton, and D. I. Gabrilovich (2008)
Blood 111, 2220-2229
   Abstract »    Full Text »    PDF »
Notch and bone morphogenetic protein differentially act on dermomyotome cells to generate endothelium, smooth, and striated muscle.
R. Ben-Yair and C. Kalcheim (2008)
J. Cell Biol. 180, 607-618
   Abstract »    Full Text »    PDF »
Suberoyl Bis-Hydroxamic Acid Activates Notch-1 Signaling and Induces Apoptosis in Medullary Thyroid Carcinoma Cells.
L. Ning, D. Y. Greenblatt, M. Kunnimalaiyaan, and H. Chen (2008)
Oncologist 13, 98-104
   Abstract »    Full Text »    PDF »
ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila.
A. Ganguly, R.M. R. Feldman, and M. Guo (2008)
Hum. Mol. Genet. 17, 293-302
   Abstract »    Full Text »    PDF »
Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage.
Y. Elkabetz, G. Panagiotakos, G. Al Shamy, N. D. Socci, V. Tabar, and L. Studer (2008)
Genes & Dev. 22, 152-165
   Abstract »    Full Text »    PDF »
Ubiquitination and Degradation of Tal1/SCL Are Induced by Notch Signaling and Depend on Skp2 and CHIP.
L. Nie, H. Wu, and X.-H. Sun (2008)
J. Biol. Chem. 283, 684-692
   Abstract »    Full Text »    PDF »
Regulation of Notch Signaling by Dynamic Changes in the Precision of S3 Cleavage of Notch-1.
S. Tagami, M. Okochi, K. Yanagida, A. Ikuta, A. Fukumori, N. Matsumoto, Y. Ishizuka-Katsura, T. Nakayama, N. Itoh, J. Jiang, et al. (2008)
Mol. Cell. Biol. 28, 165-176
   Abstract »    Full Text »    PDF »
Expression of Delta-Like Protein 4 in the Human Endometrium.
J. Mazella, S. Liang, and L. Tseng (2008)
Endocrinology 149, 15-19
   Abstract »    Full Text »    PDF »
Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus.
J. J. Breunig, J. Silbereis, F. M. Vaccarino, N. Sestan, and P. Rakic (2007)
PNAS 104, 20558-20563
   Abstract »    Full Text »    PDF »
Delta-like 4/Notch Signaling and Its Therapeutic Implications.
M. Yan and G. D. Plowman (2007)
Clin. Cancer Res. 13, 7243-7246
   Abstract »    Full Text »    PDF »
Notch-GATA synergy promotes endoderm-specific expression of ref-1 in C. elegans.
A. Neves, K. English, and J. R. Priess (2007)
Development 134, 4459-4468
   Abstract »    Full Text »    PDF »
Delta-like 4 Notch Ligand Regulates Tumor Angiogenesis, Improves Tumor Vascular Function, and Promotes Tumor Growth In vivo.
J.-L. Li, R. C.A. Sainson, W. Shi, R. Leek, L. S. Harrington, M. Preusser, S. Biswas, H. Turley, E. Heikamp, J. A. Hainfellner, et al. (2007)
Cancer Res. 67, 11244-11253
   Abstract »    Full Text »    PDF »
Investigating the Genetic Circuitry of Mastermind in Drosophila, a Notch Signal Effector.
M. W. Kankel, G. D. Hurlbut, G. Upadhyay, V. Yajnik, B. Yedvobnick, and S. Artavanis-Tsakonas (2007)
Genetics 177, 2493-2505
   Abstract »    Full Text »    PDF »
Therapeutic Implications of Leukemic Stem Cell Pathways.
S. Chumsri, W. Matsui, and A. M. Burger (2007)
Clin. Cancer Res. 13, 6549-6554
   Abstract »    Full Text »    PDF »
Mapping the Binding Site on Small Ankyrin 1 for Obscurin.
M. A. Borzok, D. H. Catino, J. D. Nicholson, A. Kontrogianni-Konstantopoulos, and R. J. Bloch (2007)
J. Biol. Chem. 282, 32384-32396
   Abstract »    Full Text »    PDF »
Epidermal Growth Factor Receptor and Notch Pathways Participate in the Tumor Suppressor Function of {gamma}-Secretase.
T. Li, H. Wen, C. Brayton, P. Das, L. A. Smithson, A. Fauq, X. Fan, B. J. Crain, D. L. Price, T. E. Golde, et al. (2007)
J. Biol. Chem. 282, 32264-32273
   Abstract »    Full Text »    PDF »
Regulation of Functional Phenotypes of Cord Blood Derived Eosinophils by {gamma}-Secretase Inhibitor.
J. H. Kang, D. H. Lee, H. Seo, J. S. Park, K. H. Nam, S. Y. Shin, C.-S. Park, and I. Y. Chung (2007)
Am. J. Respir. Cell Mol. Biol. 37, 571-577
   Abstract »    Full Text »    PDF »
Phylogenetic Footprinting Analysis in the Upstream Regulatory Regions of the Drosophila Enhancer of split Genes.
M. L. Maeder, B. J. Polansky, B. E. Robson, and D. A. Eastman (2007)
Genetics 177, 1377-1394
   Abstract »    Full Text »    PDF »
Carboxyl-terminal Proteolytic Processing of CUX1 by a Caspase Enables Transcriptional Activation in Proliferating Cells.
M. Truscott, J.-B. Denault, B. Goulet, L. Leduy, G. S. Salvesen, and A. Nepveu (2007)
J. Biol. Chem. 282, 30216-30226
   Abstract »    Full Text »    PDF »
Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein.
K. Lan, S. C. Verma, M. Murakami, B. Bajaj, R. Kaul, and E. S. Robertson (2007)
PNAS 104, 16287-16292
   Abstract »    Full Text »    PDF »
Moderate Reduction of {gamma}-Secretase Attenuates Amyloid Burden and Limits Mechanism-Based Liabilities.
T. Li, H. Wen, C. Brayton, F. M. Laird, G. Ma, S. Peng, L. Placanica, T. C. Wu, B. J. Crain, D. L. Price, et al. (2007)
J. Neurosci. 27, 10849-10859
   Abstract »    Full Text »    PDF »
A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool.
M. G. Del Barrio, R. Taveira-Marques, Y. Muroyama, D.-I. Yuk, S. Li, M. Wines-Samuelson, J. Shen, H. K. Smith, M. Xiang, D. Rowitch, et al. (2007)
Development 134, 3427-3436
   Abstract »    Full Text »    PDF »
putzig Is Required for Cell Proliferation and Regulates Notch Activity in Drosophila.
S. J. Kugler and A. C. Nagel (2007)
Mol. Biol. Cell 18, 3733-3740
   Abstract »    Full Text »    PDF »
Specificity and Autoregulation of Notch Binding by Tandem WW Domains in Suppressor of Deltex.
M. D. Jennings, R. T. Blankley, M. Baron, A. P. Golovanov, and J. M. Avis (2007)
J. Biol. Chem. 282, 29032-29042
   Abstract »    Full Text »    PDF »
Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells.
M. A. Santos, L. M. Sarmento, M. Rebelo, A. A. Doce, I. Maillard, A. Dumortier, H. Neves, F. Radtke, W. S. Pear, L. Parreira, et al. (2007)
PNAS 104, 15454-15459
   Abstract »    Full Text »    PDF »
Tip60 Histone Acetyltransferase Acts as a Negative Regulator of Notch1 Signaling by Means of Acetylation.
M.-Y. Kim, E.-J. Ann, J.-Y. Kim, J.-S. Mo, J.-H. Park, S.-Y. Kim, M.-S. Seo, and H.-S. Park (2007)
Mol. Cell. Biol. 27, 6506-6519
   Abstract »    Full Text »    PDF »
Oxygen Concentration Determines the Biological Effects of NOTCH-1 Signaling in Adenocarcinoma of the Lung.
Y. Chen, M. A. De Marco, I. Graziani, A. F. Gazdar, P. R. Strack, L. Miele, and M. Bocchetta (2007)
Cancer Res. 67, 7954-7959
   Abstract »    Full Text »    PDF »
The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1.
W.-R. Liao, R.-H. Hsieh, K.-W. Hsu, M.-Z. Wu, M.-J. Tseng, R.-T. Mai, Y.-H. Wu Lee, and T.-S. Yeh (2007)
Carcinogenesis 28, 1867-1876
   Abstract »    Full Text »    PDF »
Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor.
M. L. Coleman, M. A. McDonough, K. S. Hewitson, C. Coles, J. Mecinovic, M. Edelmann, K. M. Cook, M. E. Cockman, D. E. Lancaster, B. M. Kessler, et al. (2007)
J. Biol. Chem. 282, 24027-24038
   Abstract »    Full Text »    PDF »
Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture.
S. Estrach, J. Legg, and F. M. Watt (2007)
J. Cell Sci. 120, 2944-2952
   Abstract »    Full Text »    PDF »
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia.
B. J. Thompson, S. Buonamici, M. L. Sulis, T. Palomero, T. Vilimas, G. Basso, A. Ferrando, and I. Aifantis (2007)
J. Exp. Med. 204, 1825-1835
   Abstract »    Full Text »    PDF »
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to {gamma}-secretase inhibitors.
J. O'Neil, J. Grim, P. Strack, S. Rao, D. Tibbitts, C. Winter, J. Hardwick, M. Welcker, J. P. Meijerink, R. Pieters, et al. (2007)
J. Exp. Med. 204, 1813-1824
   Abstract »    Full Text »    PDF »
A Role for Notch Signaling in Human Corneal Epithelial Cell Differentiation and Proliferation.
A. Ma, M. Boulton, B. Zhao, C. Connon, J. Cai, and J. Albon (2007)
Invest. Ophthalmol. Vis. Sci. 48, 3576-3585
   Abstract »    Full Text »    PDF »
Integrin-Linked Kinase Controls Notch1 Signaling by Down-Regulation of Protein Stability through Fbw7 Ubiquitin Ligase.
J.-S. Mo, M.-Y. Kim, S.-O. Han, I.-S. Kim, E.-J. Ann, K. S. Lee, M.-S. Seo, J.-Y. Kim, S.-C. Lee, J.-W. Park, et al. (2007)
Mol. Cell. Biol. 27, 5565-5574
   Abstract »    Full Text »    PDF »
Valproic Acid Activates Notch-1 Signaling and Regulates the Neuroendocrine Phenotype in Carcinoid Cancer Cells.
D. Y. Greenblatt, A. M. Vaccaro, R. Jaskula-Sztul, L. Ning, M. Haymart, M. Kunnimalaiyaan, and H. Chen (2007)
Oncologist 12, 942-951
   Abstract »    Full Text »    PDF »
Modeling Notch Signaling in Normal and Neoplastic Hematopoiesis: Global Gene Expression Profiling in Response to Activated Notch Expression.
U. Ganapati, H. T. Tan, M. Lynch, M. Dolezal, S. de Vos, and J. C. Gasson (2007)
Stem Cells 25, 1872-1880
   Abstract »    Full Text »    PDF »
Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo.
I. Geffers, K. Serth, G. Chapman, R. Jaekel, K. Schuster-Gossler, R. Cordes, D. B. Sparrow, E. Kremmer, S. L. Dunwoodie, T. Klein, et al. (2007)
J. Cell Biol. 178, 465-476
   Abstract »    Full Text »    PDF »
Antiparallel Segregation of Notch Components in the Immunological Synapse Directs Reciprocal Signaling in Allogeneic Th:DC Conjugates.
W. H. Luty, D. Rodeberg, J. Parness, and Y. M. Vyas (2007)
J. Immunol. 179, 819-829
   Abstract »    Full Text »    PDF »
CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS.
D. Skokos and M. C. Nussenzweig (2007)
J. Exp. Med. 204, 1525-1531
   Abstract »    Full Text »    PDF »
Synergism between NF-{kappa}B1/p50 and Notch2 during the Development of Marginal Zone B Lymphocytes.
S. T. Moran, A. Cariappa, H. Liu, B. Muir, D. Sgroi, C. Boboila, and S. Pillai (2007)
J. Immunol. 179, 195-200
   Abstract »    Full Text »    PDF »
The expression and functions of glycoconjugates in neural stem cells.
M. Yanagisawa and R. K Yu (2007)
Glycobiology 17, 57R-74R
   Abstract »    Full Text »    PDF »
Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems.
M. K. Taylor, K. Yeager, and S. J. Morrison (2007)
Development 134, 2435-2447
   Abstract »    Full Text »    PDF »
Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-{kappa}B signaling.
C. L. Curry, L. L. Reed, E. Broude, T. E. Golde, L. Miele, and K. E. Foreman (2007)
Mol. Cancer Ther. 6, 1983-1992
   Abstract »    Full Text »    PDF »
Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia.
S. M. Chan, A. P. Weng, R. Tibshirani, J. C. Aster, and P. J. Utz (2007)
Blood 110, 278-286
   Abstract »    Full Text »    PDF »
Progressive activation of Delta-Notch signaling from around the blastopore is required to set up a functional caudal lobe in the spider Achaearanea tepidariorum.
H. Oda, O. Nishimura, Y. Hirao, H. Tarui, K. Agata, and Y. Akiyama-Oda (2007)
Development 134, 2195-2205
   Abstract »    Full Text »    PDF »
Delta-Like 4 Induces Notch Signaling in Macrophages: Implications for Inflammation.
E. Fung, S.-M. T. Tang, J. P. Canner, K. Morishige, J. F. Arboleda-Velasquez, A. A. Cardoso, N. Carlesso, J. C. Aster, and M. Aikawa (2007)
Circulation 115, 2948-2956
   Abstract »    Full Text »    PDF »
Notch Signaling in Blood Vessels: Who Is Talking to Whom About What?.
J. J. Hofmann and M. L. Iruela-Arispe (2007)
Circ. Res. 100, 1556-1568
   Abstract »    Full Text »    PDF »
Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo.
T. Oyama, K. Harigaya, A. Muradil, K. Hozumi, S. Habu, H. Oguro, A. Iwama, K. Matsuno, R. Sakamoto, M. Sato, et al. (2007)
PNAS 104, 9764-9769
   Abstract »    Full Text »    PDF »
Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless.
D. F. Kelly, R. J. Lake, T. Walz, and S. Artavanis-Tsakonas (2007)
PNAS 104, 9591-9596
   Abstract »    Full Text »    PDF »
Molecular cloning and characterization of the Caenorhabditis elegans {alpha}1,3-fucosyltransferase family.
K. Nguyen, I. van Die, K. M Grundahl, Z. S Kawar, and R. D Cummings (2007)
Glycobiology 17, 586-599
   Abstract »    Full Text »    PDF »
Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers.
A. Krejci and S. Bray (2007)
Genes & Dev. 21, 1322-1327
   Abstract »    Full Text »    PDF »
A Novel RBP-J{kappa}-Dependent Switch from C/EBPbeta to C/EBP{zeta} at the C/EBP Binding Site on the C-Reactive Protein Promoter.
P. P. Singh, B. Voleti, and A. Agrawal (2007)
J. Immunol. 178, 7302-7309
   Abstract »    Full Text »    PDF »
Cyclic Strain Regulates the Notch/CBF-1 Signaling Pathway in Endothelial Cells: Role in Angiogenic Activity.
D. Morrow, J. P. Cullen, P. A. Cahill, and E. M. Redmond (2007)
Arterioscler. Thromb. Vasc. Biol. 27, 1289-1296
   Abstract »    Full Text »    PDF »
Joint Estimates of Quantitative Trait Locus Effect and Frequency Using Synthetic Recombinant Populations of Drosophila melanogaster.
S. J. Macdonald and A. D. Long (2007)
Genetics 176, 1261-1281
   Abstract »    Full Text »    PDF »
Stra13 regulates satellite cell activation by antagonizing Notch signaling.
H. Sun, L. Li, C. Vercherat, N. T. Gulbagci, S. Acharjee, J. Li, T.-K. Chung, T. H. Thin, and R. Taneja (2007)
J. Cell Biol. 177, 647-657
   Abstract »    Full Text »  &