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Science 30 April 1999: Vol. 284. no. 5415, pp. 765 - 770 DOI: 10.1126/science.284.5415.765
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Review
A Cell's Sense of Direction
Carole A. Parent,
Peter N. Devreotes
*
In eukaryotic cells directional sensing is mediated by
heterotrimeric guanine nucleotide-binding protein (G protein)-linked signaling pathways. In Dictyostelium discoideum amoebae and
mammalian leukocytes, the receptors and G-protein subunits are
uniformly distributed around the cell perimeter. Chemoattractants
induce the transient appearance of binding sites for several pleckstrin homology domain-containing proteins on the inner face of the
membrane. In gradients of attractant these sites are persistently
present on the side of the cell facing the higher concentration, even in the absence of a functional actin cytoskeleton or cell movement. Thus, the cell senses direction by spatially regulating the activity of
the signal transduction pathway.
Department of Biological Chemistry, Johns Hopkins University
School of Medicine, Baltimore, MD 21205, USA.
*
To whom correspondence should be addressed. E-mail:
pnd{at}welchlink.welch.jhu.edu
Read the Full Text
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