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Science 30 April 1999: Vol. 284. no. 5415, pp. 765 - 770 DOI: 10.1126/science.284.5415.765
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Review
A Cell's Sense of Direction
Carole A. Parent,
Peter N. Devreotes
*
In eukaryotic cells directional sensing is mediated by
heterotrimeric guanine nucleotide-binding protein (G protein)-linked signaling pathways. In Dictyostelium discoideum amoebae and
mammalian leukocytes, the receptors and G-protein subunits are
uniformly distributed around the cell perimeter. Chemoattractants
induce the transient appearance of binding sites for several pleckstrin homology domain-containing proteins on the inner face of the
membrane. In gradients of attractant these sites are persistently
present on the side of the cell facing the higher concentration, even in the absence of a functional actin cytoskeleton or cell movement. Thus, the cell senses direction by spatially regulating the activity of
the signal transduction pathway.
Department of Biological Chemistry, Johns Hopkins University
School of Medicine, Baltimore, MD 21205, USA.
*
To whom correspondence should be addressed. E-mail:
pnd{at}welchlink.welch.jhu.edu
Read the Full Text
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- A transcriptional profile of multicellular development in Dictyostelium discoideum.
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Development
129, 1543-1552
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- EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration.
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FASEB J
15, 2649-2659
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- Cytoskeleton-dependent Membrane Domain Segregation during Neutrophil Polarization.
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Mol. Biol. Cell
12, 3550-3562
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- Single-Molecule Analysis of Chemotactic Signaling in Dictyostelium Cells.
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Science
294, 864-867
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- Amoeboid leukocyte crawling through extracellular matrix: lessons from the Dictyostelium paradigm of cell movement.
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J. Leukoc. Biol.
70, 491-509
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- Abnormal Migration Phenotype of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2-/- Neutrophils in Zigmond Chambers Containing Formyl-Methionyl-Leucyl-Phenylalanine Gradients.
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J. Immunol.
167, 3953-3961
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- Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum.
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Development
128, 3473-3483
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