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Science 23 April 1999:
Vol. 284. no. 5414, pp. 606 - 609
DOI: 10.1126/science.284.5414.606
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Transcriptional Coregulators in Development

Mattias Mannervik, Yutaka Nibu, Hailan Zhang, Michael Levine *

Small differences in the levels of an extracellular signaling molecule can specify cell fate during development. Threshold responses are often determined at the level of transcription. Cell-specific and spatially localized patterns of gene expression depend on combinations of sequence-specific activators and repressors that bind to extensive cis-regulatory regions. Different mechanisms for integrating this complex regulatory information are discussed, particularly the role of coregulatory proteins, which are recruited to the DNA template by sequence-specific transcription factors. Recent studies suggest that a growing set of coactivators and corepressors mediate communication between diverse upstream regulatory proteins and the core RNA polymerase II transcription complex.

Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, CA 94720, USA.
*   To whom correspondence should be addressed. E-mail: mlevine{at}uclink4.berkeley.edu

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