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Science 16 April 1999:
Vol. 284. no. 5413, pp. 496 - 499
DOI: 10.1126/science.284.5413.496
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Reports

SPA1, a WD-Repeat Protein Specific to Phytochrome A Signal Transduction

Ute Hoecker, James M. Tepperman, Peter H. Quail *

The five members of the phytochrome photoreceptor family of Arabidopsis thaliana control morphogenesis differentially in response to light. Genetic analysis has identified a signaling pathway that is specifically activated by phytochrome A. A component in this pathway, SPA1 (for "suppressor of phyA-105"), functions in repression of photomorphogenesis and is required for normal photosensory specificity of phytochrome A. Molecular cloning of the SPA1 gene indicates that SPA1 is a WD (tryptophan-aspartic acid)-repeat protein that also shares sequence similarity with protein kinases. SPA1 can localize to the nucleus, suggesting a possible function in phytochrome A-specific regulation of gene expression.

Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720, USA, and U.S. Department of Agriculture/Agricultural Research Service Plant Gene Expression Center, 800 Buchanan Street, Albany, CA 94710, USA.
*   To whom correspondence should be addressed. E-mail: quail{at}nature.berkeley.edu

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