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Science 2 April 1999:
Vol. 284. no. 5411, pp. 151 - 153
DOI: 10.1126/science.284.5411.151
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Reports

ROUGH SHEATH2: A Myb Protein That Represses knox Homeobox Genes in Maize Lateral Organ Primordia

Marja C. P. , Timmermans, 12 Andrew Hudson, 3 Philip W. Becraft, 4 Timothy Nelson 1*

The regulation of members of the knotted1-like homeobox (knox) gene family is required for the normal initiation and development of lateral organs. The maize rough sheath2 (rs2) gene, which encodes a Myb-domain protein, is expressed in lateral organ primordia and their initials. Mutations in the rs2 gene permit ectopic expression of knox genes in leaf and floral primordia, causing a variety of developmental defects. Ectopic KNOX protein accumulation in rs2 mutants occurs in a subset of the normal rs2-expressing cells. This variegated accumulation of KNOX proteins in rs2 mutants suggests that rs2 represses knox expression through epigenetic means.

1 Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
2 Cold Spring Harbor Laboratory, Post Office Box 100, Cold Spring Harbor, NY 11724, USA.
3 Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, EH9 3JH, UK.
4 Zoology and Genetics Department, Iowa State University, Ames, IA 50011, USA.
*   To whom correspondence should be addressed. E-mail: timothy.nelson{at}yale.edu

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