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Science 2 April 1999:
Vol. 284. no. 5411, pp. 143 - 147
DOI: 10.1126/science.284.5411.143
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Reports

Multilineage Potential of Adult Human Mesenchymal Stem Cells

Mark F. Pittenger, 1* Alastair M. Mackay, 1 Stephen C. Beck, 1 Rama K. Jaiswal, 1 Robin Douglas, 1 Joseph D. Mosca, 1 Mark A. Moorman, 1 Donald W. Simonetti, 1 Stewart Craig, 1 Daniel R. Marshak 12

Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Cells that have the characteristics of human mesenchymal stem cells were isolated from marrow aspirates of volunteer donors. These cells displayed a stable phenotype and remained as a monolayer in vitro. These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential.

1 Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043, USA.
2 Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
*   To whom correspondence should be addressed. E-mail: mpittenger{at}osiristx.com

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FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/{beta}-catenin signaling-dependent Runx2 expression.
Z. Hamidouche, E. Hay, P. Vaudin, P. Charbord, R. Schule, P. J. Marie, and O. Fromigue (2008)
FASEB J 22, 3813-3822
   Abstract »    Full Text »    PDF »
Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Improves Diabetic Polyneuropathy in Rats.
T. Shibata, K. Naruse, H. Kamiya, M. Kozakae, M. Kondo, Y. Yasuda, N. Nakamura, K. Ota, T. Tosaki, T. Matsuki, et al. (2008)
Diabetes 57, 3099-3107
   Abstract »    Full Text »    PDF »
In vitro neovasculogenic potential of resident adipose tissue precursors.
R. Madonna and R. De Caterina (2008)
Am J Physiol Cell Physiol 295, C1271-C1280
   Abstract »    Full Text »    PDF »
Regulation of cell proliferation by intermediate-conductance Ca2+-activated potassium and volume-sensitive chloride channels in mouse mesenchymal stem cells.
R. Tao, C.-P. Lau, H.-F. Tse, and G.-R. Li (2008)
Am J Physiol Cell Physiol 295, C1409-C1416
   Abstract »    Full Text »    PDF »
Cyclic ADP-Ribose-Mediated Expansion and Stimulation of Human Mesenchymal Stem Cells by the Plant Hormone Abscisic Acid.
S. Scarfi, C. Ferraris, F. Fruscione, C. Fresia, L. Guida, S. Bruzzone, C. Usai, A. Parodi, E. Millo, A. Salis, et al. (2008)
Stem Cells 26, 2855-2864
   Abstract »    Full Text »    PDF »
Antitumoral Activity and Osteogenic Potential of Mesenchymal Stem Cells Expressing the Urokinase-Type Plasminogen Antagonist Amino-Terminal Fragment in a Murine Model of Osteolytic Tumor.
V. Fritz, D. Noel, C. Bouquet, P. Opolon, R. Voide, F. Apparailly, P. Louis-Plence, C. Bouffi, H. Drissi, C. Xie, et al. (2008)
Stem Cells 26, 2981-2990
   Abstract »    Full Text »    PDF »
Identification of a tumor-initiating stem cell population in human renal carcinomas.
B. Bussolati, S. Bruno, C. Grange, U. Ferrando, and G. Camussi (2008)
FASEB J 22, 3696-3705
   Abstract »    Full Text »    PDF »
Factors that influence short-term homing of human bone marrow-derived mesenchymal stem cells in a xenogeneic animal model.
C. Kyriakou, N. Rabin, A. Pizzey, A. Nathwani, and K. Yong (2008)
Haematologica 93, 1457-1465
   Abstract »    Full Text »    PDF »
Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation.
A. S. Rowlands, P. A. George, and J. J. Cooper-White (2008)
Am J Physiol Cell Physiol 295, C1037-C1044
   Abstract »    Full Text »    PDF »
IFATS Collection: In Vivo Therapeutic Potential of Human Adipose Tissue Mesenchymal Stem Cells After Transplantation into Mice with Liver Injury.
A. Banas, T. Teratani, Y. Yamamoto, M. Tokuhara, F. Takeshita, M. Osaki, M. Kawamata, T. Kato, H. Okochi, and T. Ochiya (2008)
Stem Cells 26, 2705-2712
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Mesenchymal Stem Cells Alter Migratory Property of T and Dendritic Cells to Delay the Development of Murine Lethal Acute Graft-Versus-Host Disease.
H. Li, Z. Guo, X. Jiang, H. Zhu, X. Li, and N. Mao (2008)
Stem Cells 26, 2531-2541
   Abstract »    Full Text »    PDF »
Migration of Neurotrophic Factors-Secreting Mesenchymal Stem Cells Toward a Quinolinic Acid Lesion as Viewed by Magnetic Resonance Imaging.
O. Sadan, N. Shemesh, R. Barzilay, M. Bahat-Stromza, E. Melamed, Y. Cohen, and D. Offen (2008)
Stem Cells 26, 2542-2551
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Allogeneic Injection of Fetal Membrane-Derived Mesenchymal Stem Cells Induces Therapeutic Angiogenesis in a Rat Model of Hind Limb Ischemia.
S. Ishikane, S. Ohnishi, K. Yamahara, M. Sada, K. Harada, K. Mishima, K. Iwasaki, M. Fujiwara, S. Kitamura, N. Nagaya, et al. (2008)
Stem Cells 26, 2625-2633
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CD105-Positive Cells in Pulmonary Arterial Blood of Adult Human Lung Cancer Patients Include Mesenchymal Progenitors.
H. Chiba, G. Ishii, T.-K. Ito, K. Aoyagi, H. Sasaki, K. Nagai, and A. Ochiai (2008)
Stem Cells 26, 2523-2530
   Abstract »    Full Text »    PDF »
Reconstitution of Schwannian Stroma in Neuroblastomas Using Human Bone Marrow Stromal Cells.
W. Du, N. Hozumi, M. Sakamoto, J.-i. Hata, and T. Yamada (2008)
Am. J. Pathol. 173, 1153-1164
   Abstract »    Full Text »    PDF »


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