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Science 2 April 1999:
Vol. 284. no. 5411, pp. 143 - 147
DOI: 10.1126/science.284.5411.143
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Reports

Multilineage Potential of Adult Human Mesenchymal Stem Cells

Mark F. Pittenger, 1* Alastair M. Mackay, 1 Stephen C. Beck, 1 Rama K. Jaiswal, 1 Robin Douglas, 1 Joseph D. Mosca, 1 Mark A. Moorman, 1 Donald W. Simonetti, 1 Stewart Craig, 1 Daniel R. Marshak 12

Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Cells that have the characteristics of human mesenchymal stem cells were isolated from marrow aspirates of volunteer donors. These cells displayed a stable phenotype and remained as a monolayer in vitro. These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential.

1 Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231-3043, USA.
2 Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
*   To whom correspondence should be addressed. E-mail: mpittenger{at}osiristx.com

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Differential Response of Adult and Embryonic Mesenchymal Progenitor Cells to Mechanical Compression in Hydrogels.
V. Terraciano, N. Hwang, L. Moroni, H. B. Park, Z. Zhang, J. Mizrahi, D. Seliktar, and J. Elisseeff (2007)
Stem Cells 25, 2730-2738
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Concise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair Current Views.
D. G. Phinney and D. J. Prockop (2007)
Stem Cells 25, 2896-2902
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Characterization of ScAP-23, a new cell line from murine subcutaneous adipose tissue, identifies genes for the molecular definition of preadipocytes.
J. Y. Kim, Y. Wu, and C. M. Smas (2007)
Physiol Genomics 31, 328-342
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In vitro cardiomyogenic differentiation of adult human bone marrow mesenchymal stem cells. The role of 5-azacytidine.
P. Antonitsis, E. Ioannidou-Papagiannaki, A. Kaidoglou, and C. Papakonstantinou (2007)
Interactive CardioVascular and Thoracic Surgery 6