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Science 19 March 1999:
Vol. 283. no. 5409, pp. 1914 - 1919
DOI: 10.1126/science.283.5409.1914
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Reports
Crystal Structure of Human ZAG, a Fat-Depleting Factor Related to MHC Molecules
Luis M. Sánchez,
1*
Arthur
J. Chirino,
12*
Pamela J. Bjorkman
12
Zn- 2-glycoprotein (ZAG) is a soluble protein
that is present in serum and other body fluids. ZAG stimulates lipid
degradation in adipocytes and causes the extensive fat losses
associated with some advanced cancers. The 2.8 angstrom crystal
structure of ZAG resembles a class I major histocompatibility complex
(MHC) heavy chain, but ZAG does not bind the class I light chain
 2-microglobulin. The ZAG structure includes a large
groove analogous to class I MHC peptide binding grooves. Instead of a
peptide, the ZAG groove contains a nonpeptidic compound that may be
implicated in lipid catabolism under normal or pathological conditions.
1 Division of Biology 156-29 and
2 Howard Hughes Medical Institute, California
Institute of Technology, Pasadena, CA 91125, USA.
*
These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail:
bjorkman{at}cco.caltech.edu
Read the Full Text
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