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Science 12 March 1999:
Vol. 283. no. 5408, pp. 1745 - 1748
DOI: 10.1126/science.283.5408.1745
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Reports

Linear Differentiation of Cytotoxic Effectors into Memory T Lymphocytes

Joseph T. Opferman, 1 Bertram T. Ober, 2 Philip G. Ashton-Rickardt 123*

A central question in immunology is the origin of long-lived T cell memory that confers protection against recurrent infection. The differentiation of naïve T cell receptor transgenic CD8+ cells into effector cytotoxic T lymphocytes (CTLs) and memory CD8+ cells was studied. Memory CD8+ cells that were generated after strong antigenic stimulation were the progeny of cytotoxic effectors and retained antigen-specific cytolytic activity 10 weeks after adoptive transfer to antigen-free recipient mice. Thus, potential vaccines based on CTL memory will require the differentiation of naïve cells into post-effector memory T cells.

1 Committee on Immunology,
2 Department of Pathology,
3 Committee on Developmental Biology, The University of Chicago, Gwen Knapp Center for Lupus and Immunology Research, Chicago, IL 60637, USA.
*   To whom correspondence should be addressed. E-mail: pashton{at}midway.uchicago.edu

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   Abstract »    Full Text »
Arrested Differentiation, the Self-Renewing Memory Lymphocyte, and Vaccination.
D. T. Fearon, P. Manders, and S. D. Wagner (2001)
Science 293, 248-250
   Abstract »    Full Text »
Unlocking the secrets of cytotoxic granule proteins.
M. J. Smyth, J. M. Kelly, V. R. Sutton, J. E. Davis, K. A. Browne, T. J. Sayers, and J. A. Trapani (2001)
J. Leukoc. Biol. 70, 18-29
   Abstract »    Full Text »    PDF »
Generation and biochemical analysis of human effector CD4 T cells: alterations in tyrosine phosphorylation and loss of CD3{zeta} expression.
S. Krishnan, V. G. Warke, M. P. Nambiar, H. K. Wong, G. C. Tsokos, and D. L. Farber (2001)
Blood 97, 3851-3859
   Abstract »    Full Text »    PDF »
Suicide induced by cytolytic activity controls the differentiation of memory CD8+ T lymphocytes.
J. T. Opferman, B. T. Ober, R. Narayanan, and P. G. Ashton-Rickardt (2001)
Int. Immunol. 13, 411-419
   Abstract »    Full Text »    PDF »


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