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Science 12 March 1999:
Vol. 283. no. 5408, pp. 1742 - 1745
DOI: 10.1126/science.283.5408.1742
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Reports

Truncated RanGAP Encoded by the Segregation Distorter Locus of Drosophila

Cynthia Merrill, Leyla Bayraktaroglu, * Ayumi Kusano, Barry Ganetzky dagger

Segregation Distorter (SD) in Drosophila melanogaster is a naturally occurring meiotic drive system in which the SD chromosome is transmitted from SD/SD+ males in vast excess over its homolog owing to the induced dysfunction of SD+-bearing spermatids. The Sd locus is the key distorting gene responsible for this phenotype. A genomic fragment from the Sd region conferred full distorting activity when introduced into the appropriate genetic background by germline transformation. The only functional product encoded by this fragment is a truncated version of the RanGAP nuclear transport protein. These results demonstrate that this mutant RanGAP is the functional Sd product.

Laboratory of Genetics, 445 Henry Mall, University of Wisconsin, Madison, WI 53706, USA.
*   Present address: Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.

dagger    To whom correspondence should be addressed. E-mail: ganetzky{at}facstaff.wisc.edu

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