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Science 19 February 1999:
Vol. 283. no. 5405, pp. 1183 - 1186
DOI: 10.1126/science.283.5405.1183
Prev | Table of Contents

Reports

Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

Marie-Clotilde Rissoan, 1* Vassili Soumelis, 1* Norimitsu Kadowaki, 2* Geraldine Grouard, 1 Francine Briere, 1 René de Waal Malefyt, 2 Yong-Jun Liu 12dagger

It is not known whether subsets of dendritic cells provide different cytokine microenvironments that determine the differentiation of either type-1 T helper (TH1) or TH2 cells. Human monocyte (pDC1)-derived dendritic cells (DC1) were found to induce TH1 differentiation, whereas dendritic cells (DC2) derived from CD4+CD3-CD11c- plasmacytoid cells (pDC2) induced TH2 differentiation by use of a mechanism unaffected by interleukin-4 (IL-4) or IL-12. The TH2 cytokine IL-4 enhanced DC1 maturation and killed pDC2, an effect potentiated by IL-10 but blocked by CD40 ligand and interferon-gamma . Thus, a negative feedback loop from the mature T helper cells may selectively inhibit prolonged TH1 or TH2 responses by regulating survival of the appropriate dendritic cell subset.

1 Schering-Plough, Laboratory for Immunological Research, 27 chemin des Peupliers, Boite Postale 11, 69571, Dardilly, France.
2 DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304-1104, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: yliu{at}dnax.org

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Tumoricidal Potential of Native Blood Dendritic Cells: Direct Tumor Cell Killing and Activation of NK Cell-Mediated Cytotoxicity.
M. Schmitz, S. Zhao, Y. Deuse, K. Schakel, R. Wehner, H. Wohner, K. Holig, F. Wienforth, A. Kiessling, M. Bornhauser, et al. (2005)
J. Immunol. 174, 4127-4134
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Immune regulatory activity of CD34+ progenitor cells: evidence for a deletion-based mechanism mediated by TNF-{alpha}.
H. Gur, R. Krauthgamer, E. Bachar-Lustig, H. Katchman, R. Arbel-Goren, A. Berrebi, T. Klein, A. Nagler, A. Tabilio, M. F. Martelli, et al. (2005)
Blood 105, 2585-2593
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The CMRF58 antibody recognizes a subset of CD123hi dendritic cells in allergen-challenged mucosa.
S. Vuckovic, D. Khalil, N. Angel, F. Jahnsen, I. Hamilton, A. Boyce, B. Hock, and D. N. J. Hart (2005)
J. Leukoc. Biol. 77, 344-351
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Variegation of the Immune Response with Dendritic Cells and Pathogen Recognition Receptors.
B. Pulendran (2005)
J. Immunol. 174, 2457-2465
   Abstract »    Full Text »    PDF »
Human TLR10 Is a Functional Receptor, Expressed by B Cells and Plasmacytoid Dendritic Cells, Which Activates Gene Transcription through MyD88.
U. Hasan, C. Chaffois, C. Gaillard, V. Saulnier, E. Merck, S. Tancredi, C. Guiet, F. Briere, J. Vlach, S. Lebecque, et al. (2005)
J. Immunol. 174, 2942-2950
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Compartmental Imbalance and Aberrant Immune Function of Blood CD123+ (Plasmacytoid) and CD11c+ (Myeloid) Dendritic Cells in Atopic Dermatitis.
H. Hashizume, T. Horibe, H. Yagi, N. Seo, and M. Takigawa (2005)
J. Immunol. 174, 2396-2403
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Plasmacytoid precursor dendritic cells facilitate allogeneic hematopoietic stem cell engraftment.
I. J. Fugier-Vivier, F. Rezzoug, Y. Huang, A. J. Graul-Layman, C. L. Schanie, H. Xu, P. M. Chilton, and S. T. Ildstad (2005)
J. Exp. Med. 201, 373-383
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Development and Activation of Human Dendritic Cells In Vivo in a Xenograft Model of Human Hematopoiesis.
P. D. Cravens, M. W. Melkus, A. Padgett-Thomas, M. Islas-Ohlmayer, M. del P. Martin, and J. V. Garcia (2005)
Stem Cells 23, 264-278
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Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells.
F. Garnache-Ottou, L. Chaperot, S. Biichle, C. Ferrand, J.-P. Remy-Martin, E. Deconinck, P. D. de Tailly, B. Bulabois, J. Poulet, E. Kuhlein, et al. (2005)
Blood 105, 1256-1264
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Plasmacytoid Dendritic Cells: Linking Innate and Adaptive Immunity.
K. McKenna, A.-S. Beignon, and N. Bhardwaj (2005)
J. Virol. 79, 17-27
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Capacity of myeloid and plasmacytoid dendritic cells especially at mature stage to express and secrete HLA-G molecules.
G. Le Friec, F. Gros, Y. Sebti, V. Guilloux, C. Pangault, R. Fauchet, and L. Amiot (2004)
J. Leukoc. Biol. 76, 1125-1133
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High Levels of Interleukin-12 Are Associated with Reduced Incidence of Relapse and Death without Increasing Acute Graft-Versus-Host Disease (AGVHD) after Allogeneic Stem Cell Transplantation (SCT)..
V. Reddy, A. G. Winer, E. Eksioglu, J. Levine, H.-U. Meier-Kriesche, J. Schold, H. Mossak, and J. R. Wingard (2004)
Blood (ASH Annual Meeting Abstracts) 104, 295
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Dendritic Cell Infiltration and Prognosis of Early Stage Breast Cancer.
I. Treilleux, J.-Y. Blay, N. Bendriss-Vermare, I. Ray-Coquard, T. Bachelot, J.-P. Guastalla, A. Bremond, S. Goddard, J.-J. Pin, C. Barthelemy-Dubois, et al. (2004)
Clin. Cancer Res. 10, 7466-7474
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Increased Levels of Interleukin-10 in Serum from Patients with Hepatocellular Carcinoma Correlate with Profound Numerical Deficiencies and Immature Phenotype of Circulating Dendritic Cell Subsets.
S. Beckebaum, X. Zhang, X. Chen, Z. Yu, A. Frilling, G. Dworacki, H. Grosse-Wilde, C. E. Broelsch, G. Gerken, and V. R. Cicinnati (2004)
Clin. Cancer Res. 10, 7260-7269
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Regulation of differentiation and functional properties of monocytes and monocyte-derived dendritic cells by interferon beta in multiple sclerosis.
Y. C. Zang, S. M Skinner, R. R Robinson, S. Li, V. M Rivera, G. J Hutton, and J. Z Zhang (2004)
Multiple Sclerosis 10, 499-506
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Food allergy in irritable bowel syndrome: new facts and old fallacies.
E Isolauri, S Rautava, and M Kalliomaki (2004)
Gut 53, 1391-1393
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Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells.
E. A. Moseman, X. Liang, A. J. Dawson, A. Panoskaltsis-Mortari, A. M. Krieg, Y.-J. Liu, B. R. Blazar, and W. Chen (2004)
J. Immunol. 173, 4433-4442
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Herpes Simplex Virus Type-1-Induced Activation of Myeloid Dendritic Cells: The Roles of Virus Cell Interaction and Paracrine Type I IFN Secretion.
G. Pollara, M. Jones, M. E. Handley, M. Rajpopat, A. Kwan, R. S. Coffin, G. Foster, B. Chain, and D. R. Katz (2004)
J. Immunol. 173, 4108-4119
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Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation.
G. Schlecht, S. Garcia, N. Escriou, A. A. Freitas, C. Leclerc, and G. Dadaglio (2004)
Blood 104, 1808-1815
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Dendritic Cells Stimulated with Actinobacillus actinomycetemcomitans Elicit Rapid Gamma Interferon Responses by Natural Killer Cells.
T. Kikuchi, C. L. Hahn, S. Tanaka, S. E. Barbour, H. A. Schenkein, and J. G. Tew (2004)
Infect. Immun. 72, 5089-5096
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CD16+ human monocyte-derived dendritic cells matured with different and unrelated stimuli promote similar allogeneic Th2 responses: regulation by pro- and anti-inflammatory cytokines.
A. Rivas-Carvalho, M. A. Meraz-Rios, L. Santos-Argumedo, S. Bajana, G. Soldevila, M. E. Moreno-Garcia, and C. Sanchez-Torres (2004)
Int. Immunol. 16, 1251-1263
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