Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 19 February 1999:
Vol. 283. no. 5405, pp. 1180 - 1183
DOI: 10.1126/science.283.5405.1180
Prev | Table of Contents | Next

Reports

Regulation of Neurotrophin-3 Expression by Epithelial- Mesenchymal Interactions: The Role of Wnt Factors

Ardem Patapoutian, 1* Carey Backus, 2 Andreas Kispert, 3 Louis F. Reichardt 12

Neurotrophins regulate survival, axonal growth, and target innervation of sensory and other neurons. Neurotrophin-3 (NT-3) is expressed specifically in cells adjacent to extending axons of dorsal root ganglia neurons, and its absence results in loss of most of these neurons before their axons reach their targets. However, axons are not required for NT-3 expression in limbs; instead, local signals from ectoderm induce NT-3 expression in adjacent mesenchyme. Wnt factors expressed in limb ectoderm induce NT-3 in the underlying mesenchyme. Thus, epithelial-mesenchymal interactions mediated by Wnt factors control NT-3 expression and may regulate axonal growth and guidance.

1 Department of Physiology,
2 Howard Hughes Medical Institute, University of California, San Francisco, CA 94143-0723, USA.
3 Department of Molecular Embryology, Max-Planck-Institute for Immunobiology, Stuebeweg 51, D-79108 Freiburg, Germany.
*   To whom correspondence should be addressed. E-mail: ardem{at}itsa.ucsf.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Louis Reichardt: The long climb to science's summits.
N. LeBrasseur (2009)
J. Cell Biol. 186, 634-635
   Full Text »    PDF »
Growth and Patterning in the Limb: Signaling Gradients Make the Decision.
Y. Yang (2009)
Science Signaling 2, pe3
   Abstract »    Full Text »    PDF »
Characterization of Wnt Signaling during Photoreceptor Degeneration.
H. Yi, R. E. I. Nakamura, O. Mohamed, D. Dufort, and A. S. Hackam (2007)
Invest. Ophthalmol. Vis. Sci. 48, 5733-5741
   Abstract »    Full Text »    PDF »
Neurotrophin-regulated signalling pathways.
L. F Reichardt (2006)
Phil Trans R Soc B 361, 1545-1564
   Abstract »    Full Text »    PDF »
Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgf{beta}1 regulate semaphorin 3a expression in the dental mesenchyme.
P. Kettunen, S. Loes, T. Furmanek, K. Fjeld, I. H. Kvinnsland, O. Behar, T. Yagi, H. Fujisawa, S. Vainio, M. Taniguchi, et al. (2005)
Development 132, 323-334
   Abstract »    Full Text »    PDF »
Spatial Shaping of Cochlear Innervation by Temporally Regulated Neurotrophin Expression.
I. Farinas, K. R. Jones, L. Tessarollo, A. J. Vigers, E. Huang, M. Kirstein, D. C. de Caprona, V. Coppola, C. Backus, L. F. Reichardt, et al. (2001)
J. Neurosci. 21, 6170-6180
   Abstract »    Full Text »    PDF »
Controls of Hair Follicle Cycling.
K. S. Stenn and R. Paus (2001)
Physiol Rev 81, 449-494
   Abstract »    Full Text »    PDF »
Ectopic engrailed 1 expression in the dorsal midline causes cell death, abnormal differentiation of circumventricular organs and errors in axonal pathfinding.
A Louvi and M Wassef (2000)
Development 127, 4061-4071
   Abstract »    PDF »
Molecular Signaling and Pulpal Nerve Development.
K. Fried, C. Nosrat, C. Lillesaar, and C. Hildebrand (2000)
Critical Reviews in Oral Biology & Medicine 11, 318-332
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)