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Science 5 February 1999:
Vol. 283. no. 5403, pp. 845 - 848
DOI: 10.1126/science.283.5403.845
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Reports

Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4

Amnon Peled, 1 Isabelle Petit, 1 Orit Kollet, 1 Michal Magid, 1 Tanya Ponomaryov, 1 Tamara Byk, 1 Arnon Nagler, 3 Herzl Ben-Hur, 4 Ariel Many, 5 Leonard Shultz, 6 Ofer Lider, 1 Ronen Alon, 1 Dov Zipori, 2 Tsvee Lapidot 1*

Stem cell homing and repopulation are not well understood. The chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 were found to be critical for murine bone marrow engraftment by human severe combined immunodeficient (SCID) repopulating stem cells. Treatment of human cells with antibodies to CXCR4 prevented engraftment. In vitro CXCR4-dependent migration to SDF-1 of CD34+CD38-/low cells correlated with in vivo engraftment and stem cell function. Stem cell factor and interleukin-6 induced CXCR4 expression on CD34+ cells, which potentiated migration to SDF-1 and engraftment in primary and secondary transplanted mice. Thus, up-regulation of CXCR4 expression may be useful for improving engraftment of repopulating stem cells in clinical transplantation.

1 Department of Immunology and
2 Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.
3 Hadassah University Hospital Jerusalem, 91120, Israel.
4 Kaplan Medical Center, Rehovot 76100, Israel.
5 Sourasky Medical Center, Tel Aviv 64239, Israel.
6 The Jackson Laboratory, Bar Harbor, ME 04609, USA.
*   To whom correspondence should be addressed. E-mail: litsvee{at}weizmann.weizmann.ac.il

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The Chemokine SDF-1/CXCL12 Binds to and Signals through the Orphan Receptor RDC1 in T Lymphocytes.
K. Balabanian, B. Lagane, S. Infantino, K. Y. C. Chow, J. Harriague, B. Moepps, F. Arenzana-Seisdedos, M. Thelen, and F. Bachelerie (2005)
J. Biol. Chem. 280, 35760-35766
   Abstract »    Full Text »    PDF »
Sharing the Same Vascular Addressins for Osteotropic Behavior of Hematopoietic Progenitor Cells and Cancer.
C. J. Dimitroff (2005)
IBMS BoneKEy 2, 16-19
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A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis.
M. Rosu-Myles, E. Stewart, J. Trowbridge, C. Y. Ito, P. Zandstra, and M. Bhatia (2005)
J. Cell Sci. 118, 4343-4352
   Abstract »    Full Text »    PDF »
Complement C3a Enhances CXCL12 (SDF-1)-Mediated Chemotaxis of Bone Marrow Hematopoietic Cells Independently of C3a Receptor.
M. Honczarenko, M. Z. Ratajczak, A. Nicholson-Weller, and L. E. Silberstein (2005)
J. Immunol. 175, 3698-3706
   Abstract »    Full Text »    PDF »
How do stem cells find their way home?.
T. Lapidot, A. Dar, and O. Kollet (2005)
Blood 106, 1901-1910
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Motility, proliferation, and egress to the circulation of human AML cells are elastase dependent in NOD/SCID chimeric mice.
S. Tavor, I. Petit, S. Porozov, P. Goichberg, A. Avigdor, S. Sagiv, A. Nagler, E. Naparstek, and T. Lapidot (2005)
Blood 106, 2120-2127
   Abstract »    Full Text »    PDF »
Lessons from the bone marrow: how malignant glioma cells attract adult haematopoietic progenitor cells.
G. Tabatabai, O. Bahr, R. Mohle, I. Y. Eyupoglu, A. M. Boehmler, J. Wischhusen, J. Rieger, I. Blumcke, M. Weller, and W. Wick (2005)
Brain 128, 2200-2211
   Abstract »    Full Text »    PDF »
Efficient marking of human cells with rapid but transient repopulating activity in autografted recipients.
H. Glimm, M. Schmidt, M. Fischer, K. Schwarzwaelder, M. Wissler, S. Klingenberg, C. Prinz, C. F. Waller, W. Lange, C. J. Eaves, et al. (2005)
Blood 106, 893-898
   Abstract »    Full Text »    PDF »
Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets.
V. Sordi, M. L. Malosio, F. Marchesi, A. Mercalli, R. Melzi, T. Giordano, N. Belmonte, G. Ferrari, B. E. Leone, F. Bertuzzi, et al. (2005)
Blood 106, 419-427
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Transforming growth factor-{beta}1 modulates responses of CD34+ cord blood cells to stromal cell-derived factor-1/CXCL12.
S. Basu and H. E. Broxmeyer (2005)
Blood 106, 485-493
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Tie2 activation contributes to hemangiogenic regeneration after myelosuppression.
H.-G. Kopp, S. T. Avecilla, A. T. Hooper, S. V. Shmelkov, C. A. Ramos, F. Zhang, and S. Rafii (2005)
Blood 106, 505-513
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Identification of Leukocyte E-Selectin Ligands, P-Selectin Glycoprotein Ligand-1 and E-Selectin Ligand-1, on Human Metastatic Prostate Tumor Cells.
C. J. Dimitroff, L. Descheny, N. Trujillo, R. Kim, V. Nguyen, W. Huang, K. J. Pienta, J. L. Kutok, and M. A. Rubin (2005)
Cancer Res. 65, 5750-5760
   Abstract »    Full Text »    PDF »
Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1{alpha} in the circulation.
D. A. Davis, K. E. Singer, M. De La Luz Sierra, M. Narazaki, F. Yang, H. M. Fales, R. Yarchoan, and G. Tosato (2005)
Blood 105, 4561-4568
   Abstract »    Full Text »    PDF »
Leukocyte migration and graft-versus-host disease.
C. A. Wysocki, A. Panoskaltsis-Mortari, B. R. Blazar, and J. S. Serody (2005)
Blood 105, 4191-4199
   Abstract »    Full Text »    PDF »
Murine hematopoietic stem cells change their surface phenotype during ex vivo expansion.
C. C. Zhang and H. F. Lodish (2005)
Blood 105, 4314-4320
   Abstract »    Full Text »    PDF »


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