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Science 22 January 1999:
Vol. 283. no. 5401, pp. 532 - 534
DOI: 10.1126/science.283.5401.532
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Reports

Recruitment of a hedgehog Regulatory Circuit in Butterfly Eyespot Evolution

David N. Keys, * David L. Lewis, * Jane E. Selegue, Bret J. Pearson, Lisa V. Goodrich, Ronald L. Johnson, dagger Julie Gates, ddagger Matthew P. Scott, Sean B. Carroll §

The origin of new morphological characters is a long-standing problem in evolutionary biology. Novelties arise through changes in development, but the nature of these changes is largely unknown. In butterflies, eyespots have evolved as new pattern elements that develop from special organizers called foci. Formation of these foci is associated with novel expression patterns of the Hedgehog signaling protein, its receptor Patched, the transcription factor Cubitus interruptus, and the engrailed target gene that break the conserved compartmental restrictions on this regulatory circuit in insect wings. Redeployment of preexisting regulatory circuits may be a general mechanism underlying the evolution of novelties.

D. N. Keys, D. L. Lewis, J. E. Selegue, B. J. Pearson, J. Gates, S. B. Carroll, Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA. L. V. Goodrich, R. L. Johnson, M. P. Scott, Howard Hughes Medical Research Institute, Beckman Center, Stanford University Medical Center, Palo Alto, CA 94304, USA.
*   These authors contributed equally to this work.

dagger    Present address: Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

ddagger    Present address: Howard Hughes Medical Institute, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA.

§   To whom correspondence should be addressed. E-mail: sbcarrol{at}facstaff.wisc.edu

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