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Science 15 January 1999:
Vol. 283. no. 5400, pp. 404 - 406
DOI: 10.1126/science.283.5400.404
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Reports

Diminishing Returns from Mutation Supply Rate in Asexual Populations

J. Arjan G., M. de Visser, *dagger Clifford W. Zeyl, Philip J. Gerrish, Jeffrey L. Blanchard, Richard E. Lenski

Mutator genotypes with increased mutation rates may be especially important in microbial evolution if genetic adaptation is generally limited by the supply of mutations. In experimental populations of the bacterium Escherichia coli, the rate of evolutionary adaptation was proportional to the mutation supply rate only in particular circumstances of small or initially well-adapted populations. These experiments also demonstrate a "speed limit" on adaptive evolution in asexual populations, one that is independent of the mutation supply rate.

J. A. G. M. de Visser and R. E. Lenski, Center for Microbial Ecology, Michigan State University, East Lansing, MI 48824, USA. C. W. Zeyl, Department of Biology, Wake Forest University, Winston-Salem, NC 27109, USA. P. J. Gerrish, Centers for Disease Control, Atlanta, GA 30333, USA. J. L. Blanchard, Department of Biology, University of Oregon, Eugene, OR 97403, USA.
*   Present address: Laboratory of Microbiology, Wageningen Agricultural University, Wageningen, The Netherlands.

dagger    To whom correspondence should be addressed. E-mail: arjan.devisser{at}algemeen.micr.wau.nl

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