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Science 1 January 1999:
Vol. 283. no. 5398, pp. 83 - 87
DOI: 10.1126/science.283.5398.83
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Reports

The Transcriptional Program in the Response of Human Fibroblasts to Serum

Vishwanath R. Iyer, Michael B. Eisen, Douglas T. Ross, Greg Schuler, Troy Moore, Jeffrey C. F. Lee, Jeffrey M. Trent, Louis M. Staudt, James Hudson Jr., Mark S. Boguski, Deval Lashkari, Dari Shalon, David Botstein, Patrick O. Brown *

The temporal program of gene expression during a model physiological response of human cells, the response of fibroblasts to serum, was explored with a complementary DNA microarray representing about 8600 different human genes. Genes could be clustered into groups on the basis of their temporal patterns of expression in this program. Many features of the transcriptional program appeared to be related to the physiology of wound repair, suggesting that fibroblasts play a larger and richer role in this complex multicellular response than had previously been appreciated.

V. R. Iyer and D. T. Ross, Department of Biochemistry, Stanford University School of Medicine, Stanford CA 94305, USA. M. B. Eisen and D. Botstein, Department of Genetics, Stanford University School of Medicine, Stanford CA 94305, USA. G. Schuler and M. S. Boguski, National Center for Biotechnology Information, Bethesda MD 20894, USA. T. Moore and J. Hudson Jr., Research Genetics, Huntsville, AL 35801, USA. J. C. F. Lee, D. Lashkari, D. Shalon, Incyte Pharmaceuticals, Fremont, CA 94555, USA. J. M. Trent, Laboratory of Cancer Genetics, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. L. M. Staudt, Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA. P. O. Brown, Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford CA 94305, USA.
*   To whom correspondence should be addressed. E-mail: pbrown{at}cmgm.stanford.edu

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Proliferative Effects of Heparin-Binding Epidermal Growth Factor-like Growth Factor on Pterygium Epithelial Cells and Fibroblasts.
T. M. Nolan, N. Di Girolamo, M. T. Coroneo, and D. Wakefield (2004)
Invest. Ophthalmol. Vis. Sci. 45, 110-113
   Abstract »    Full Text »    PDF »
Anti-Invasive Gene Expression Profile of Curcumin in Lung Adenocarcinoma Based on a High Throughput Microarray Analysis.
H.-W. Chen, S.-L. Yu, J. J. W. Chen, H.-N. Li, Y.-C. Lin, P.-L. Yao, H.-Y. Chou, C.-T. Chien, W.-J. Chen, Y.-T. Lee, et al. (2004)
Mol. Pharmacol. 65, 99-110
   Abstract »    Full Text »    PDF »
A Novel Protein Highly Expressed in Testis Is Overexpressed in Systemic Sclerosis Fibroblasts and Targeted by Autoantibodies.
H. Yasuoka, H. Ihn, T. A. Medsger Jr, M. Hirakata, Y. Kawakami, Y. Ikeda, and M. Kuwana (2003)
J. Immunol. 171, 6883-6890
   Abstract »    Full Text »    PDF »
Bayesian Machine Learning and Its Potential Applications to the Genomic Study of Oral Oncology.
P. Sebastiani, Y.-H. Yu, and M.F. Ramoni (2003)
Advances in Dental Research 17, 104-108
   Abstract »    Full Text »    PDF »
Molecular responses of human muscle to eccentric exercise.
Y.-W. Chen, M. J. Hubal, E. P. Hoffman, P. D. Thompson, and P. M. Clarkson (2003)
J Appl Physiol 95, 2485-2494
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Toward a Functional Annotation of the Human Genome Using Artificial Transcription Factors.
D.-k. Lee, J. W. Park, Y.-J. Kim, J. Kim, Y. Lee, J. Kim, and J.-S. Kim (2003)
Genome Res. 13, 2708-2716
   Abstract »    Full Text »    PDF »
Gene Expression Analysis of Prostate Hyperplasia in Mice Overexpressing the Prolactin Gene Specifically in the Prostate.
K. Dillner, J. Kindblom, A. Flores-Morales, R. Shao, J. Tornell, G. Norstedt, and H. Wennbo (2003)
Endocrinology 144, 4955-4966
   Abstract »    Full Text »    PDF »
EXCAVATOR: a computer program for efficiently mining gene expression data.
D. Xu, V. Olman, L. Wang, and Y. Xu (2003)
Nucleic Acids Res. 31, 5582-5589
   Abstract »    Full Text »    PDF »
Gene Microarray Analysis of Experimental Glaucomatous Retina from Cynomologous Monkey.
T. Miyahara, T. Kikuchi, M. Akimoto, T. Kurokawa, H. Shibuki, and N. Yoshimura (2003)
Invest. Ophthalmol. Vis. Sci. 44, 4347-4356
   Abstract »    Full Text »    PDF »
Gene Expression Profiling of the Effects of Castration and Estrogen Treatment in the Rat Uterus.
X. Wu, S.-T. Pang, L. Sahlin, A. Blanck, G. Norstedt, and A. Flores-Morales (2003)
Biol Reprod 69, 1308-1317
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Repression of the Human Adenine Nucleotide Translocase-2 Gene in Growth-arrested Human Diploid Cells: THE ROLE OF NUCLEAR FACTOR-1.
K. Luciakova, P. Barath, D. Poliakova, A. Persson, and B. D. Nelson (2003)
J. Biol. Chem. 278, 30624-30633
   Abstract »    Full Text »    PDF »
Altered patterns of gene expression distinguishing ascending aortic aneurysms from abdominal aortic aneurysms: complementary DNA expression profiling in the molecular characterization of aortic disease.
T. S. Absi, T. M. Sundt III, W. S. Tung, M. Moon, J. K. Lee, R. R. Damiano Jr, and R. W. Thompson (2003)
J. Thorac. Cardiovasc. Surg. 126, 344-357
   Abstract »    Full Text »    PDF »


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