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Science 18 December 1998:
Vol. 282. no. 5397, pp. 2266 - 2269
DOI: 10.1126/science.282.5397.2266
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Reports

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

Christoph Wülfing, Mark M. Davis *

During T cell activation, the engagement of costimulatory molecules is often crucial to the development of an effective immune response, but the mechanism by which this is achieved is not known. Here, it is shown that beads attached to the surface of a T cell translocate toward the interface shortly after the start of T cell activation. This movement appears to depend on myosin motor proteins and requires the engagement of the major costimulatory receptor pairs, B7-CD28 and ICAM-1-LFA-1. This suggests that the engagement of costimulatory receptors triggers an active accumulation of molecules at the interface of the T cell and the antigen-presenting cell, which then increases the overall amplitude and duration of T cell signaling.

Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
*   To whom correspondence should be addressed.

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J. Cell Biol. 158, 1263-1275
   Abstract »    Full Text »    PDF »
Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction.
N. Guerra, F. Michel, A. Gati, C. Gaudin, Z. Mishal, B. Escudier, O. Acuto, S. Chouaib, and A. Caignard (2002)
Blood 100, 2874-2881
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Cutting Edge: Quantitative Imaging of Raft Accumulation in the Immunological Synapse.
W. R. Burack, K.-H. Lee, A. D. Holdorf, M. L. Dustin, and A. S. Shaw (2002)
J. Immunol. 169, 2837-2841
   Abstract »    Full Text »    PDF »
Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation.
M. Diehn, A. A. Alizadeh, O. J. Rando, C. L. Liu, K. Stankunas, D. Botstein, G. R. Crabtree, and P. O. Brown (2002)
PNAS 99, 11796-11801
   Abstract »    Full Text »    PDF »
Essential Role of NF-{kappa}B-Inducing Kinase in T Cell Activation Through the TCR/CD3 Pathway.
M. Matsumoto, T. Yamada, S. K. Yoshinaga, T. Boone, T. Horan, S. Fujita, Y. Li, and T. Mitani (2002)
J. Immunol. 169, 1151-1158
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TCR Engagement Induces Proline-Rich Tyrosine Kinase-2 (Pyk2) Translocation to the T Cell-APC Interface Independently of Pyk2 Activity and in an Immunoreceptor Tyrosine-Based Activation Motif-Mediated Fashion.
D. Sancho, M. C. Montoya, A. Monjas, M. Gordon-Alonso, T. Katagiri, D. Gil, R. Tejedor, B. Alarcon, and F. Sanchez-Madrid (2002)
J. Immunol. 169, 292-300
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Polar Redistribution of the Sialoglycoprotein CD43: Implications for T Cell Function.
N. D. L. Savage, S. L. Kimzey, S. K. Bromley, K. G. Johnson, M. L. Dustin, and J. M. Green (2002)
J. Immunol. 168, 3740-3746
   Abstract »    Full Text »    PDF »
Intercellular transfer of antigen-presenting cell determinants onto T cells: molecular mechanisms and biological significance.
D. HUDRISIER and P. BONGRAND (2002)
FASEB J 16, 477-486
   Abstract »    Full Text »    PDF »
Cutting Edge: Differential Segregation of the Src Homology 2-Containing Protein Tyrosine Phosphatase-1 Within the Early NK Cell Immune Synapse Distinguishes Noncytolytic from Cytolytic Interactions.
Y. M. Vyas, H. Maniar, and B. Dupont (2002)
J. Immunol. 168, 3150-3154
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CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase.
E. Gubina, T. Chen, L. Zhang, E. F. Lizzio, and S. Kozlowski (2002)
Blood 99, 2518-2525
   Abstract »    Full Text »    PDF »
Focal Localization of Placental Protein 14 Toward Sites of TCR Engagement.
J. Rachmilewitz, Z. Borovsky, G. Mishan-Eisenberg, E. Yaniv, G. J. Riely, and M. L. Tykocinski (2002)
J. Immunol. 168, 2745-2750
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A Novel Serine-rich Motif in the Intercellular Adhesion Molecule 3 Is Critical for Its Ezrin/Radixin/Moesin-directed Subcellular Targeting.
J. M. Serrador, M. Vicente-Manzanares, J. Calvo, O. Barreiro, M. C. Montoya, R. Schwartz-Albiez, H. Furthmayr, F. Lozano, and F. Sanchez-Madrid (2002)
J. Biol. Chem. 277, 10400-10409
   Abstract »    Full Text »    PDF »
The role of lipid rafts in signalling and membrane trafficking in T lymphocytes.
M. A. Alonso and J. Millan (2002)
J. Cell Sci. 114, 3957-3965
   Abstract »    Full Text »    PDF »
How and Why Does the Immunological Synapse Form? Physical Chemistry Meets Cell Biology.
A. K. Chakraborty (2002)
Sci. STKE 2002, pe10
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Rho GTPases link cytoskeletal rearrangements and activation processes induced via the tetraspanin CD82 in T lymphocytes.
A. Delaguillaumie, C. Lagaudriere-Gesbert, M. R. Popoff, and H. Conjeaud (2002)
J. Cell Sci. 115, 433-443
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Cutting Edge: Negative Regulation of Immune Synapse Formation by Anchoring Lipid Raft to Cytoskeleton Through Cbp-EBP50-ERM Assembly.
K. Itoh, M. Sakakibara, S. Yamasaki, A. Takeuchi, H. Arase, M. Miyazaki, N. Nakajima, M. Okada, and T. Saito (2002)
J. Immunol. 168, 541-544
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