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Science 18 December 1998:
Vol. 282. no. 5397, pp. 2258 - 2261
DOI: 10.1126/science.282.5397.2258
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Reports

Interleukin-13: Central Mediator of Allergic Asthma

Marsha Wills-Karp, * Jackie Luyimbazi, Xueying Xu, Brian Schofield, Tamlyn Y. Neben, Christopher L. Karp, Debra D. Donaldson

The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4+ T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.

M. Wills-Karp, J. Luyimbazi, X. Xu, B. Schofield, Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA. T. Y. Neben and D. D. Donaldson, Immunology Department, Genetics Institute, Cambridge, MA 02140, USA. C. L. Karp, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA, and Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA.
*   To whom correspondence should be addressed. E-mail: mkarp{at}welchlink.welch.jhu.edu

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Am. J. Respir. Cell Mol. Biol. 37, 273-290
   Abstract »    Full Text »    PDF »
Novel Recombinant Interleukin-13 Peptide-based Vaccine Reduces Airway Allergic Inflammatory Responses in Mice.
Y. Ma, K. T. HayGlass, A. B. Becker, Y. Fan, X. Yang, S. Basu, G. Srinivasan, F. E. R. Simons, A. J. Halayko, and Z. Peng (2007)
Am. J. Respir. Crit. Care Med. 176, 439-445
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Inhibition of Experimental Allergic Airways Disease by Local Application of a Cell-Penetrating Dominant-Negative STAT-6 Peptide.
C. T. McCusker, Y. Wang, J. Shan, M. W. Kinyanjui, A. Villeneuve, H. Michael, and E. D. Fixman (2007)
J. Immunol. 179, 2556-2564
   Abstract »    Full Text »    PDF »
Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung.
A. Mishra, M. Wang, J. Schlotman, N. M. Nikolaidis, C. W. DeBrosse, M. L. Karow, and M. E. Rothenberg (2007)
Am J Physiol Lung Cell Mol Physiol 293, L305-L313
   Abstract »    Full Text »    PDF »
Measurement of IL-13-Induced iNOS-Derived Gas Phase Nitric Oxide in Human Bronchial Epithelial Cells.
V. Suresh, J. D. Mih, and S. C. George (2007)
Am. J. Respir. Cell Mol. Biol. 37, 97-104
   Abstract »    Full Text »    PDF »
Galectin-9 Inhibits CD44-Hyaluronan Interaction and Suppresses a Murine Model of Allergic Asthma.
S. Katoh, N. Ishii, A. Nobumoto, K. Takeshita, S.-Y. Dai, R. Shinonaga, T. Niki, N. Nishi, A. Tominaga, A. Yamauchi, et al. (2007)
Am. J. Respir. Crit. Care Med. 176, 27-35
   Abstract »    Full Text »    PDF »
T-cell co-stimulatory molecules: their role in allergic immune reactions.
T. Kallinich, K. C. Beier, U. Wahn, P. Stock, and E. Hamelmann (2007)
Eur. Respir. J. 29, 1246-1255
   Abstract »    Full Text »    PDF »
4-1BB triggers IL-13 production from T cells to limit the polarized, Th1-mediated inflammation.
S. M. Shin, Y. H. Kim, B. K. Choi, P. M. Kwon, H.-W. Lee, and B. S. Kwon (2007)
J. Leukoc. Biol. 81, 1455-1465
   Abstract »    Full Text »    PDF »
Lack of lymphoid chemokines CCL19 and CCL21 enhances allergic airway inflammation in mice.
B. Xu, K. Aoyama, M. Kusumoto, A. Matsuzawa, E. C. Butcher, S. A. Michie, T. Matsuyama, and T. Takeuchi (2007)
Int. Immunol. 19, 775-784
   Abstract »    Full Text »    PDF »
Comparison of Airway Remodeling in Acute, Subacute, and Chronic Models of Allergic Airways Disease.
N. R. Locke, S. G. Royce, J. S. Wainewright, C. S. Samuel, and M. L. Tang (2007)
Am. J. Respir. Cell Mol. Biol. 36, 625-632
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Remodeling and Airway Hyperresponsiveness but Not Cellular Inflammation Persist after Allergen Challenge in Asthma.
H. H. Kariyawasam, M. Aizen, J. Barkans, D. S. Robinson, and A. B. Kay (2007)
Am. J. Respir. Crit. Care Med. 175, 896-904
   Abstract »    Full Text »    PDF »
A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice.
Q. Wu, R. J. Martin, J. G. Rino, S. Jeyaseelan, R. Breed, and H. W. Chu (2007)
Am J Physiol Lung Cell Mol Physiol 292, L1064-L1072
   Abstract »    Full Text »    PDF »
Airway Exposure Levels of Lipopolysaccharide Determine Type 1 versus Type 2 Experimental Asthma.
Y.-K. Kim, S.-Y. Oh, S. G. Jeon, H.-W. Park, S.-Y. Lee, E.-Y. Chun, B. Bang, H.-S. Lee, M.-H. Oh, Y.-S. Kim, et al. (2007)
J. Immunol. 178, 5375-5382
   Abstract »    Full Text »    PDF »
Lysophosphatidic Acid Induces Interleukin-13 (IL-13) Receptor {alpha}2 Expression and Inhibits IL-13 Signaling in Primary Human Bronchial Epithelial Cells.
Y. Zhao, D. He, J. Zhao, L. Wang, A. R. Leff, E. Wm. Spannhake, S. Georas, and V. Natarajan (2007)
J. Biol. Chem. 282, 10172-10179
   Abstract »    Full Text »    PDF »
Superantigen Presentation by Airway Smooth Muscle to CD4+ T Lymphocytes Elicits Reciprocal Proasthmatic Changes in Airway Function.
H. Veler, A. Hu, S. Fatma, J. S. Grunstein, C. M. DeStephan, D. Campbell, J. S. Orange, and M. M. Grunstein (2007)
J. Immunol. 178, 3627-3636
   Abstract »    Full Text »    PDF »
Posttranscriptional Inhibition of Interferon-Gamma Production by Lead.
Y. Heo, T. K. Mondal, D. Gao, J. Kasten-Jolly, H. Kishikawa, and D. A. Lawrence (2007)
Toxicol. Sci. 96, 92-100
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Efficacy of IL-13 Neutralization in a Sheep Model of Experimental Asthma.
M. T. Kasaian, D. D. Donaldson, L. Tchistiakova, K. Marquette, X.-Y. Tan, A. Ahmed, B. A. Jacobson, A. Widom, T. A. Cook, X. Xu, et al. (2007)
Am. J. Respir. Cell Mol. Biol. 36, 368-376
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IL-2 and IL-18 Attenuation of Airway Hyperresponsiveness Requires STAT4, IFN-{gamma}, and Natural Killer Cells.
S. Matsubara, K. Takeda, T. Kodama, A. Joetham, N. Miyahara, T. Koya, C. H. Swasey, M. Okamoto, A. Dakhama, and E. W. Gelfand (2007)
Am. J. Respir. Cell Mol. Biol. 36, 324-332
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IL-13 Mediates In Vivo IL-9 Activities on Lung Epithelial Cells but Not on Hematopoietic Cells.
V. Steenwinckel, J. Louahed, C. Orabona, F. Huaux, G. Warnier, A. McKenzie, D. Lison, R. Levitt, and J.-C. Renauld (2007)
J. Immunol. 178, 3244-3251
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Functional Dissection Identifies a Conserved Noncoding Sequence-1 Core That Mediates IL13 and IL4 Transcriptional Enhancement.
J. M. Strempel and D. Vercelli (2007)
J. Biol. Chem. 282, 3738-3746
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IL-13 and Epidermal Growth Factor Receptor Have Critical but Distinct Roles in Epithelial Cell Mucin Production.
G. Zhen, S. W. Park, L. T. Nguyenvu, M. W. Rodriguez, R. Barbeau, A. C. Paquet, and D. J. Erle (2007)
Am. J. Respir. Cell Mol. Biol. 36, 244-253
   Abstract »    Full Text »    PDF »


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