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Science 18 December 1998: Vol. 282. no. 5397, pp. 2258 - 2261 DOI: 10.1126/science.282.5397.2258
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Reports
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,
*
Jackie Luyimbazi,
Xueying Xu,
Brian Schofield,
Tamlyn Y. Neben,
Christopher L. Karp,
Debra D. Donaldson
The worldwide incidence, morbidity, and mortality of allergic
asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of
CD4+ T cells producing the type 2 cytokines interleukin-4
(IL-4) and IL-5, although a necessary role for these cytokines in
allergic asthma has not been demonstrable. The type 2 cytokine IL-13,
which shares a receptor component and signaling pathways with IL-4, was
found to be necessary and sufficient for the expression of allergic
asthma. IL-13 induces the pathophysiological features of asthma in a
manner that is independent of immunoglobulin E and eosinophils. Thus,
IL-13 is critical to allergen-induced asthma but operates through
mechanisms other than those that are classically implicated in allergic
responses.
M. Wills-Karp, J. Luyimbazi, X. Xu, B. Schofield, Department of
Environmental Health Sciences, Johns Hopkins University School of
Hygiene and Public Health, Baltimore, MD 21205, USA. T. Y. Neben and D. D. Donaldson, Immunology Department, Genetics
Institute, Cambridge, MA 02140, USA. C. L. Karp, Department
of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
21205, USA, and Department of Molecular Microbiology and Immunology,
Johns Hopkins University School of Hygiene and Public Health,
Baltimore, MD 21205, USA.
*
To whom correspondence should be addressed. E-mail:
mkarp{at}welchlink.welch.jhu.edu
Read the Full Text
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| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Full Text »
| PDF »
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| Full Text »
| PDF »
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180, 2225-2232
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| PDF »
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| Full Text »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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176, 556-564
| Abstract »
| Full Text »
| PDF »
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- N. Hayashi, T. Yoshimoto, K. Izuhara, K. Matsui, T. Tanaka, and K. Nakanishi (2007)
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104, 14765-14770
| Abstract »
| Full Text »
| PDF »
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Am. J. Respir. Cell Mol. Biol.
37, 273-290
| Abstract »
| Full Text »
| PDF »
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- Y. Ma, K. T. HayGlass, A. B. Becker, Y. Fan, X. Yang, S. Basu, G. Srinivasan, F. E. R. Simons, A. J. Halayko, and Z. Peng (2007)
Am. J. Respir. Crit. Care Med.
176, 439-445
| Abstract »
| Full Text »
| PDF »
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- C. T. McCusker, Y. Wang, J. Shan, M. W. Kinyanjui, A. Villeneuve, H. Michael, and E. D. Fixman (2007)
J. Immunol.
179, 2556-2564
| Abstract »
| Full Text »
| PDF »
- Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung.
- A. Mishra, M. Wang, J. Schlotman, N. M. Nikolaidis, C. W. DeBrosse, M. L. Karow, and M. E. Rothenberg (2007)
Am J Physiol Lung Cell Mol Physiol
293, L305-L313
| Abstract »
| Full Text »
| PDF »
- Measurement of IL-13-Induced iNOS-Derived Gas Phase Nitric Oxide in Human Bronchial Epithelial Cells.
- V. Suresh, J. D. Mih, and S. C. George (2007)
Am. J. Respir. Cell Mol. Biol.
37, 97-104
| Abstract »
| Full Text »
| PDF »
- Galectin-9 Inhibits CD44-Hyaluronan Interaction and Suppresses a Murine Model of Allergic Asthma.
- S. Katoh, N. Ishii, A. Nobumoto, K. Takeshita, S.-Y. Dai, R. Shinonaga, T. Niki, N. Nishi, A. Tominaga, A. Yamauchi, et al. (2007)
Am. J. Respir. Crit. Care Med.
176, 27-35
| Abstract »
| Full Text »
| PDF »
- T-cell co-stimulatory molecules: their role in allergic immune reactions.
- T. Kallinich, K. C. Beier, U. Wahn, P. Stock, and E. Hamelmann (2007)
Eur. Respir. J.
29, 1246-1255
| Abstract »
| Full Text »
| PDF »
- 4-1BB triggers IL-13 production from T cells to limit the polarized, Th1-mediated inflammation.
- S. M. Shin, Y. H. Kim, B. K. Choi, P. M. Kwon, H.-W. Lee, and B. S. Kwon (2007)
J. Leukoc. Biol.
81, 1455-1465
| Abstract »
| Full Text »
| PDF »
- Lack of lymphoid chemokines CCL19 and CCL21 enhances allergic airway inflammation in mice.
- B. Xu, K. Aoyama, M. Kusumoto, A. Matsuzawa, E. C. Butcher, S. A. Michie, T. Matsuyama, and T. Takeuchi (2007)
Int. Immunol.
19, 775-784
| Abstract »
| Full Text »
| PDF »
- Comparison of Airway Remodeling in Acute, Subacute, and Chronic Models of Allergic Airways Disease.
- N. R. Locke, S. G. Royce, J. S. Wainewright, C. S. Samuel, and M. L. Tang (2007)
Am. J. Respir. Cell Mol. Biol.
36, 625-632
| Abstract »
| Full Text »
| PDF »
- Remodeling and Airway Hyperresponsiveness but Not Cellular Inflammation Persist after Allergen Challenge in Asthma.
- H. H. Kariyawasam, M. Aizen, J. Barkans, D. S. Robinson, and A. B. Kay (2007)
Am. J. Respir. Crit. Care Med.
175, 896-904
| Abstract »
| Full Text »
| PDF »
- A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice.
- Q. Wu, R. J. Martin, J. G. Rino, S. Jeyaseelan, R. Breed, and H. W. Chu (2007)
Am J Physiol Lung Cell Mol Physiol
292, L1064-L1072
| Abstract »
| Full Text »
| PDF »
- Airway Exposure Levels of Lipopolysaccharide Determine Type 1 versus Type 2 Experimental Asthma.
- Y.-K. Kim, S.-Y. Oh, S. G. Jeon, H.-W. Park, S.-Y. Lee, E.-Y. Chun, B. Bang, H.-S. Lee, M.-H. Oh, Y.-S. Kim, et al. (2007)
J. Immunol.
178, 5375-5382
| Abstract »
| Full Text »
| PDF »
- Lysophosphatidic Acid Induces Interleukin-13 (IL-13) Receptor {alpha}2 Expression and Inhibits IL-13 Signaling in Primary Human Bronchial Epithelial Cells.
- Y. Zhao, D. He, J. Zhao, L. Wang, A. R. Leff, E. Wm. Spannhake, S. Georas, and V. Natarajan (2007)
J. Biol. Chem.
282, 10172-10179
| Abstract »
| Full Text »
| PDF »
- Superantigen Presentation by Airway Smooth Muscle to CD4+ T Lymphocytes Elicits Reciprocal Proasthmatic Changes in Airway Function.
- H. Veler, A. Hu, S. Fatma, J. S. Grunstein, C. M. DeStephan, D. Campbell, J. S. Orange, and M. M. Grunstein (2007)
J. Immunol.
178, 3627-3636
| Abstract »
| Full Text »
| PDF »
- Posttranscriptional Inhibition of Interferon-Gamma Production by Lead.
- Y. Heo, T. K. Mondal, D. Gao, J. Kasten-Jolly, H. Kishikawa, and D. A. Lawrence (2007)
Toxicol. Sci.
96, 92-100
| Abstract »
| Full Text »
| PDF »
- Efficacy of IL-13 Neutralization in a Sheep Model of Experimental Asthma.
- M. T. Kasaian, D. D. Donaldson, L. Tchistiakova, K. Marquette, X.-Y. Tan, A. Ahmed, B. A. Jacobson, A. Widom, T. A. Cook, X. Xu, et al. (2007)
Am. J. Respir. Cell Mol. Biol.
36, 368-376
| Abstract »
| Full Text »
| PDF »
- IL-2 and IL-18 Attenuation of Airway Hyperresponsiveness Requires STAT4, IFN-{gamma}, and Natural Killer Cells.
- S. Matsubara, K. Takeda, T. Kodama, A. Joetham, N. Miyahara, T. Koya, C. H. Swasey, M. Okamoto, A. Dakhama, and E. W. Gelfand (2007)
Am. J. Respir. Cell Mol. Biol.
36, 324-332
| Abstract »
| Full Text »
| PDF »
- IL-13 Mediates In Vivo IL-9 Activities on Lung Epithelial Cells but Not on Hematopoietic Cells.
- V. Steenwinckel, J. Louahed, C. Orabona, F. Huaux, G. Warnier, A. McKenzie, D. Lison, R. Levitt, and J.-C. Renauld (2007)
J. Immunol.
178, 3244-3251
| Abstract »
| Full Text »
| PDF »
- Functional Dissection Identifies a Conserved Noncoding Sequence-1 Core That Mediates IL13 and IL4 Transcriptional Enhancement.
- J. M. Strempel and D. Vercelli (2007)
J. Biol. Chem.
282, 3738-3746
| Abstract »
| Full Text »
| PDF »
- IL-13 and Epidermal Growth Factor Receptor Have Critical but Distinct Roles in Epithelial Cell Mucin Production.
- G. Zhen, S. W. Park, L. T. Nguyenvu, M. W. Rodriguez, R. Barbeau, A. C. Paquet, and D. J. Erle (2007)
Am. J. Respir. Cell Mol. Biol.
36, 244-253
| Abstract »
| Full Text »
| PDF »
- The Chemokine Receptor D6 Has Opposing Effects on Allergic Inflammation and Airway Reactivity.
- G. S. Whitehead, T. Wang, L. M. DeGraff, J. W. Card, S. A. Lira, G. J. Graham, and D. N. Cook (2007)
Am. J. Respir. Crit. Care Med.
175, 243-249
| Abstract »
| Full Text »
| PDF »
- C5 Modulates Airway Hyperreactivity and Pulmonary Eosinophilia during Enhanced Respiratory Syncytial Virus Disease by Decreasing C3a Receptor Expression.
- G. A. Melendi, S. J. Hoffman, R. A. Karron, P. M. Irusta, F. R. Laham, A. Humbles, B. Schofield, C.-H. Pan, R. Rabold, B. Thumar, et al. (2007)
J. Virol.
81, 991-999
| Abstract »
| Full Text »
| PDF »
- Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease.
- J. D. Milner, J. M. Ward, A. Keane-Myers, and W. E. Paul (2007)
PNAS
104, 576-581
| Abstract »
| Full Text »
| PDF »
- The Human IL-13 Locus in Neonatal CD4+ T Cells Is Refractory to the Acquisition of a Repressive Chromatin Architecture.
- R. B. Webster, Y. Rodriguez, W. T. Klimecki, and D. Vercelli (2007)
J. Biol. Chem.
282, 700-709
| Abstract »
| Full Text »
| PDF »
- Lung Fibrotic Responses to Particle Exposure.
- J. C. Bonner (2007)
Toxicol Pathol
35, 148-153
| Abstract »
| Full Text »
| PDF »
- Comparative Roles of IL-4, IL-13, and IL-4R{alpha} in Dendritic Cell Maturation and CD4+ Th2 Cell Function.
- D. C. Webb, Y. Cai, K. I. Matthaei, and P. S. Foster (2007)
J. Immunol.
178, 219-227
| Abstract »
| Full Text »
| PDF »
- Critical Role of the Fc Receptor {gamma}-Chain on APCs in the Development of Allergen-Induced Airway Hyperresponsiveness and Inflammation.
- K. Kitamura, K. Takeda, T. Koya, N. Miyahara, T. Kodama, A. Dakhama, T. Takai, A. Hirano, M. Tanimoto, M. Harada, et al. (2007)
J. Immunol.
178, 480-488
| Abstract »
| Full Text »
| PDF »
- Protectin D1 Is Generated in Asthma and Dampens Airway Inflammation and Hyperresponsiveness.
- B. D. Levy, P. Kohli, K. Gotlinger, O. Haworth, S. Hong, S. Kazani, E. Israel, K. J. Haley, and C. N. Serhan (2007)
J. Immunol.
178, 496-502
| Abstract »
| Full Text »
| PDF »
- Th2 Cell-Selective Enhancement of Human IL13 Transcription by IL13-1112C>T, a Polymorphism Associated with Allergic Inflammation.
- L. Cameron, R. B. Webster, J. M. Strempel, P. Kiesler, M. Kabesch, H. Ramachandran, L. Yu, D. A. Stern, P. E. Graves, I. C. Lohman, et al. (2006)
J. Immunol.
177, 8633-8642
| Abstract »
| Full Text »
| PDF »
- Eosinophils and CCR3 Regulate Interleukin-13 Transgene-Induced Pulmonary Remodeling.
- P. C. Fulkerson, C. A. Fischetti, and M. E. Rothenberg (2006)
Am. J. Pathol.
169, 2117-2126
| Abstract »
| Full Text »
| PDF »
- Allergy-Driven Alternative Splicing of IL-13 Receptor {alpha}2 Yields Distinct Membrane and Soluble Forms.
- Y. Tabata, W. Chen, M. R. Warrier, A. M. Gibson, M. O. Daines, and G. K. K. Hershey (2006)
J. Immunol.
177, 7905-7912
| Abstract »
| Full Text »
| PDF »
- CD38-deficient mice have reduced airway hyperresponsiveness following IL-13 challenge.
- A. G. P. Guedes, J. Paulin, L. Rivero-Nava, H. Kita, F. E. Lund, and M. S. Kannan (2006)
Am J Physiol Lung Cell Mol Physiol
291, L1286-L1293
| Abstract »
| Full Text »
| PDF »
- Specific and Redundant Roles for NFAT Transcription Factors in the Expression of Mast Cell-Derived Cytokines.
- M. Klein, S. Klein-Hessling, A. Palmetshofer, E. Serfling, C. Tertilt, T. Bopp, V. Heib, M. Becker, C. Taube, H. Schild, et al. (2006)
J. Immunol.
177, 6667-6674
| Abstract »
| Full Text »
| PDF »
- N-linked glycosylation of IL-13R{alpha}2 is essential for optimal IL-13 inhibitory activity.
- M. Kioi, S. Seetharam, and R. K. Puri (2006)
FASEB J
20, 2378-2380
| Abstract »
| Full Text »
| PDF »
- Loss of pro-apoptotic Bim promotes accumulation of pulmonary T lymphocytes and enhances allergen-induced goblet cell metaplasia.
- J. Pierce, J. Rir-Sima-Ah, I. Estrada, J. Wilder, A. Strasser, and Y. Tesfaigzi (2006)
Am J Physiol Lung Cell Mol Physiol
291, L862-L870
| Abstract »
| Full Text »
| PDF »
- IL-10- and IL-12-Independent Down-Regulation of Allergic Sensitization by Stimulation of CD40 Signaling.
- P. W. Hellings, A. Kasran, D. Bullens, L. Overbergh, C. Mathieu, H. Heremans, P. Matthys, L. Boon, M. Jorissen, and J. L. Ceuppens (2006)
J. Immunol.
177, 5138-5144
| Abstract »
| Full Text »
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- Aspergillus fumigatus Generates an Enhanced Th2-Biased Immune Response in Mice with Defective Cystic Fibrosis Transmembrane Conductance Regulator.
- J. B. Allard, M. E. Poynter, K. A. Marr, L. Cohn, M. Rincon, and L. A. Whittaker (2006)
J. Immunol.
177, 5186-5194
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| Full Text »
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- Inhibition of Arginase I Activity by RNA Interference Attenuates IL-13-Induced Airways Hyperresponsiveness.
- M. Yang, D. Rangasamy, K. I. Matthaei, A. J. Frew, N. Zimmmermann, S. Mahalingam, D. C. Webb, D. J. Tremethick, P. J. Thompson, S. P. Hogan, et al. (2006)
J. Immunol.
177, 5595-5603
| Abstract »
| Full Text »
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- Novel Approach to Inhibit Asthma-Mediated Lung Inflammation Using Anti-CD147 Intervention.
- W. M. Gwinn, J. M. Damsker, R. Falahati, I. Okwumabua, A. Kelly-Welch, A. D. Keegan, C. Vanpouille, J. J. Lee, L. A. Dent, D. Leitenberg, et al. (2006)
J. Immunol.
177, 4870-4879
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| Full Text »
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- Opposing Actions of Stat1 and Stat6 on IL-13-Induced Up-Regulation of Early Growth Response-1 and Platelet-Derived Growth Factor Ligands in Pulmonary Fibroblasts.
- J. L. Ingram, A. Antao-Menezes, J. B. Mangum, O. Lyght, P. J. Lee, J. A. Elias, and J. C. Bonner (2006)
J. Immunol.
177, 4141-4148
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- Persistent Effects Induced by IL-13 in the Lung.
- P. C. Fulkerson, C. A. Fischetti, L. M. Hassman, N. M. Nikolaidis, and M. E. Rothenberg (2006)
Am. J. Respir. Cell Mol. Biol.
35, 337-346
| Abstract »
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- The high-affinity IgE receptor (Fc{epsilon}RI): a critical regulator of airway smooth muscle cells?.
- A. S. Gounni (2006)
Am J Physiol Lung Cell Mol Physiol
291, L312-L321
| Abstract »
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- Role of Local Pulmonary IFN-{gamma} Expression in Murine Allergic Airway Inflammation.
- M. Koch, M. Witzenrath, C. Reuter, M. Herma, H. Schutte, N. Suttorp, H. Collins, and S. H. E. Kaufmann (2006)
Am. J. Respir. Cell Mol. Biol.
35, 211-219
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- Role of 5-Lipoxygenase in IL-13-Induced Pulmonary Inflammation and Remodeling.
- Y. M. Shim, Z. Zhu, T. Zheng, C. G. Lee, R. J. Homer, B. Ma, and J. A. Elias (2006)
J. Immunol.
177, 1918-1924
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- Transcription Factors T-bet and GATA-3 Regulate Development of Airway Remodeling.
- T. Kiwamoto, Y. Ishii, Y. Morishima, K. Yoh, A. Maeda, K. Ishizaki, T. Iizuka, A. E. Hegab, Y. Matsuno, S. Homma, et al. (2006)
Am. J. Respir. Crit. Care Med.
174, 142-151
| Abstract »
| Full Text »
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- Cytokines or their antagonists for the treatment of asthma..
- P. M. O'Byrne (2006)
Chest
130, 244-250
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| Full Text »
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- Immunogenetic Programs for Viral Induction of Mucous Cell Metaplasia.
- M. J. Holtzman, J. T. Battaile, and A. C. Patel (2006)
Am. J. Respir. Cell Mol. Biol.
35, 29-39
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- Level of Expression of IL-13R{alpha}2 Impacts Receptor Distribution and IL-13 Signaling..
- M. O. Daines, Y. Tabata, B. A. Walker, W. Chen, M. R. Warrier, S. Basu, and G. K. K. Hershey (2006)
J. Immunol.
176, 7495-7501
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| Full Text »
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- Contribution of IL-18 to atopic-dermatitis-like skin inflammation induced by Staphylococcus aureus product in mice.
- M. Terada, H. Tsutsui, Y. Imai, K. Yasuda, H. Mizutani, K. Yamanishi, M. Kubo, K. Matsui, H. Sano, and K. Nakanishi (2006)
PNAS
103, 8816-8821
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| Full Text »
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- Regulation of Mucin Genes in Chronic Inflammatory Airway Diseases.
- J. A. Voynow, S. J. Gendler, and M. C. Rose (2006)
Am. J. Respir. Cell Mol. Biol.
34, 661-665
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