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Science 11 December 1998:
Vol. 282. no. 5396, pp. 2079 - 2081
DOI: 10.1126/science.282.5396.2079
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Reports

Identification of alpha -Dystroglycan as a Receptor for Lymphocytic Choriomeningitis Virus and Lassa Fever Virus

Wei Cao, Michael D. Henry, Persephone Borrow, Hiroki Yamada, John H. Elder, Eugene V. Ravkov, Stuart T. Nichol, Richard W. Compans, Kevin P. Campbell, Michael B. A. Oldstone *

A peripheral membrane protein that is interactive with lymphocytic choriomeningitis virus (LCMV) was purified from cells permissive to infection. Tryptic peptides from this protein were determined to be alpha -dystroglycan (alpha -DG). Several strains of LCMV and other arenaviruses, including Lassa fever virus (LFV), Oliveros, and Mobala, bound to purified alpha -DG protein. Soluble alpha -DG blocked both LCMV and LFV infection. Cells bearing a null mutation of the gene encoding DG were resistant to LCMV infection, and reconstitution of DG expression in null mutant cells restored susceptibility to LCMV infection. Thus, alpha -DG is a cellular receptor for both LCMV and LFV.

W. Cao and M. B. A. Oldstone, Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. M. D. Henry, H. Yamada, K. P. Campbell, Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, IA 52242, USA. P. Borrow, Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, RG20 7NN, UK. J. H. Elder, Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. E. V. Ravkov and R. W. Compans, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA. S. T. Nichol, Center for Disease Control, 1600 Clifton Road, NE, MSG14, Atlanta, GA 30333, USA.
*   To whom correspondence should be addressed. E-mail address: mbaobo{at}scripps.edu

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The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P.
O. Lenz, J. ter Meulen, H.-D. Klenk, N. G. Seidah, and W. Garten (2001)
PNAS 98, 12701-12705
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Molecular analysis of the interaction of LCMV with its cellular receptor {alpha}-dystroglycan.
S. Kunz, N. Sevilla, D. B. McGavern, K. P. Campbell, and M. B.A. Oldstone (2001)
J. Cell Biol. 155, 301-310
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