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Science 11 December 1998:
Vol. 282. no. 5396, pp. 2072 - 2075
DOI: 10.1126/science.282.5396.2072
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Reports

Promotion of Trophoblast Stem Cell Proliferation by FGF4

Satoshi Tanaka, * Tilo Kunath, Anna-Katerina Hadjantonakis, Andras Nagy, Janet Rossant dagger

The trophoblast cell lineage is essential for the survival of the mammalian embryo in utero. This lineage is specified before implantation into the uterus and is restricted to form the fetal portion of the placenta. A culture of mouse blastocysts or early postimplantation trophoblasts in the presence of fibroblast growth factor 4 (FGF4) permitted the isolation of permanent trophoblast stem cell lines. These cell lines differentiated to other trophoblast subtypes in vitro in the absence of FGF4 and exclusively contributed to the trophoblast lineage in vivo in chimeras.

S. Tanaka and A.-K. Hadjantonakis, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. T. Kunath, A. Nagy, J. Rossant, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada, and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
*   Present address: Laboratory of Cellular Biochemistry, Veterinary Medical Science/Animal Resource Science, University of Tokyo, Tokyo, Japan 113-8657.

dagger    To whom correspondence should be addressed. E-mail: rossant{at}mshri.on.ca

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The Escape of the Mink Embryo from Obligate Diapause.
J. A. Desmarais, V. Bordignon, F. L. Lopes, L. C. Smith, and B. D. Murphy (2004)
Biol Reprod 70, 662-670
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Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal-fetal interface in the mouse placenta.
M. Hirashima, Y. Lu, L. Byers, and J. Rossant (2003)
PNAS 100, 15637-15642
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Mouse embryonic chimeras: tools for studying mammalian development.
P. P. L. Tam and J. Rossant (2003)
Development 130, 6155-6163
   Abstract »    Full Text »    PDF »
Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation.
H. Wang, H. Matsumoto, Y. Guo, B. C. Paria, R. L. Roberts, and S. K. Dey (2003)
PNAS 100, 14914-14919
   Abstract »    Full Text »    PDF »
Ets2-Dependent Stromal Regulation of Mouse Mammary Tumors.
A. K. Man, L. J. T. Young, J. A. Tynan, J. Lesperance, M. Egeblad, Z. Werb, C. A. Hauser, W. J. Muller, R. D. Cardiff, and R. G. Oshima (2003)
Mol. Cell. Biol. 23, 8614-8625
   Abstract »    Full Text »    PDF »
Engineered Zinc Finger Proteins for Controlling Stem Cell Fate.
V. V. Bartsevich, J. C. Miller, C. C. Case, and C. O. Pabo (2003)
Stem Cells 21, 632-637
   Abstract »    Full Text »    PDF »
Spatial and temporal patterns of ERK signaling during mouse embryogenesis.
L. B. Corson, Y. Yamanaka, K.-M. V. Lai, and J. Rossant (2003)
Development 130, 4527-4537
   Abstract »    Full Text »    PDF »
Embryonic stem cells can form germ cells in vitro.
Y. Toyooka, N. Tsunekawa, R. Akasu, and T. Noce (2003)
PNAS 100, 11457-11462
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Derivation of Oocytes from Mouse Embryonic Stem Cells.
K. Hubner, G. Fuhrmann, L. K. Christenson, J. Kehler, R. Reinbold, R. De La Fuente, J. Wood, J. F. Strauss III, M. Boiani, and H. R. Scholer (2003)
Science 300, 1251-1256
   Abstract »    Full Text »    PDF »
Inhibition of trophoblast stem cell potential in chorionic ectoderm coincides with occlusion of the ectoplacental cavity in the mouse.
G. D. Uy, K. M. Downs, and R. L. Gardner (2003)
Development 129, 3913-3924
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A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse.
R. T. Sasmono, D. Oceandy, J. W. Pollard, W. Tong, P. Pavli, B. J. Wainwright, M. C. Ostrowski, S. R. Himes, and D. A. Hume (2003)
Blood 101, 1155-1163
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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development.
H. Chen, S. A. Detmer, A. J. Ewald, E. E. Griffin, S. E. Fraser, and D. C. Chan (2003)
J. Cell Biol. 160, 189-200
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Multipotent cell lineages in early mouse development depend on SOX2 function.
A. A. Avilion, S. K. Nicolis, L. H. Pevny, L. Perez, N. Vivian, and R. Lovell-Badge (2003)
Genes & Dev. 17, 126-140
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Rapid Loss of Oct-4 and Pluripotency in Cultured Rodent Blastocysts and Derivative Cell Lines.
M. Buehr, J. Nichols, F. Stenhouse, P. Mountford, C.J. Greenhalgh, S. Kantachuvesiri, G. Brooker, J. Mullins, and A.G. Smith (2003)
Biol Reprod 68, 222-229
   Abstract »    Full Text »    PDF »
Intrinsic susceptibility of mouse trophoblasts to natural killer cell-mediated attack invivo.
A. Erlebacher, A. K. Lukens, and L. H. Glimcher (2002)
PNAS 99, 16940-16945
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Gene Expression Profiling of Embryo-Derived Stem Cells Reveals Candidate Genes Associated With Pluripotency and Lineage Specificity.
T. S. Tanaka, T. Kunath, W. L. Kimber, S. A. Jaradat, C. A. Stagg, M. Usuda, T. Yokota, H. Niwa, J. Rossant, and M. S.H. Ko (2002)
Genome Res. 12, 1921-1928
   Abstract »    Full Text »    PDF »


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