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Science 11 December 1998:
Vol. 282. no. 5396, pp. 2028 - 2033
DOI: 10.1126/science.282.5396.2028
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Review

Neurobiology of the Caenorhabditis elegans Genome

Cornelia I. Bargmann

Neurotransmitter receptors, neurotransmitter synthesis and release pathways, and heterotrimeric GTP-binding protein (G protein)-coupled second messenger pathways are highly conserved between Caenorhabditis elegans and mammals, but gap junctions and chemosensory receptors have independent origins in vertebrates and nematodes. Most ion channels are similar to vertebrate channels but there are no predicted voltage-activated sodium channels. The C. elegans genome encodes at least 80 potassium channels, 90 neurotransmitter-gated ion channels, 50 peptide receptors, and up to 1000 orphan receptors that may be chemoreceptors. For many gene families, C. elegans has both conventional members and divergent outliers with weak homology to known genes; these outliers may provide insights into previously unknown functions of conserved protein families.

The author is at the Howard Hughes Medical Institute, Programs in Developmental Biology, Neuroscience, and Genetics, Departments of Anatomy and Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0452, USA.

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S. Rajan, E. Wischmeyer, G. Xin Liu, R. Preisig-Muller, J. Daut, A. Karschin, and C. Derst (2000)
J. Biol. Chem. 275, 16650-16657
   Abstract »    Full Text »    PDF »
TWIK-2, an Inactivating 2P Domain K+ Channel.
A. J. Patel, F. Maingret, V. Magnone, M. Fosset, M. Lazdunski, and E. Honore (2000)
J. Biol. Chem. 275, 28722-28730
   Abstract »    Full Text »    PDF »
Cellular and Subcellular Localization, N-terminal Acylation, and Calcium Binding of Caenorhabditis elegans Protein Phosphatase with EF-hands.
P. Ramulu and J. Nathans (2001)
J. Biol. Chem. 276, 25127-25135
   Abstract »    Full Text »    PDF »
A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons.
J. A. Millar, L. Barratt, A. P. Southan, K. M. Page, R. E. W. Fyffe, B. Robertson, and A. Mathie (2000)
PNAS 97, 3614-3618
   Abstract »    Full Text »    PDF »
Classification of Transmembrane Protein Families in the Caenorhabditis elegans Genome and Identification of Human Orthologs.
M. Remm and E. Sonnhammer (2000)
Genome Res. 10, 1679-1689
   Abstract »    Full Text »


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