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Science 11 December 1998:
Vol. 282. no. 5396, pp. 2018 - 2022
DOI: 10.1126/science.282.5396.2018
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Review

Zinc Fingers in Caenorhabditis elegans: Finding Families and Probing Pathways

Neil D. Clarke, Jeremy M. Berg

More than 3 percent of the protein sequences inferred from the Caenorhabditis elegans genome contain sequence motifs characteristic of zinc-binding structural domains, and of these more than half are believed to be sequence-specific DNA-binding proteins. The distribution of these zinc-binding domains among the genomes of various organisms offers insights into the role of zinc-binding proteins in evolution. In addition, the complete genome sequence of C. elegans provides an opportunity to analyze, and perhaps predict, pathways of transcriptional regulation.

Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)