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Science 4 December 1998:
Vol. 282. no. 5395, pp. 1897 - 1900
DOI: 10.1126/science.282.5395.1897
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Reports

dMi-2, a Hunchback-Interacting Protein That Functions in Polycomb Repression

Johannes Kehle, * Dirk Beuchle, * Susanne Treuheit, Bea Christen, dagger James A. Kennison, Mariann Bienz, Jürg Müller ddagger §

Early in Drosophila embryogenesis, gap gene products directly repress transcription of homeotic (HOX) genes and thereby delimit HOX expression domains. Subsequently, Polycomb-group proteins maintain this repression. Currently, there is no known molecular link between gap and Polycomb-group proteins. Here, dMi-2 is identified as a protein that binds to a domain in the gap protein Hunchback that is specifically required for the repression of HOX genes. Genetic analyses show that dMi-2 participates in both Hunchback and Polycomb repression in vivo. Hence, recruitment of dMi-2 may serve as a link between repression of HOX genes by Hunchback and Polycomb proteins.

J. Kehle, D. Beuchle, S. Treuheit, Max-Planck-Institut für Entwicklungsbiologie, Spemannstrasse 35/III, 72076 Tübingen, Germany. B. Christen, M. Bienz, and J. Müller, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. J. A. Kennison, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2785, USA.
*   These two authors made equal contributions to this work.

dagger    Present address: School of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.

ddagger    Present address: Max-Planck-Institut für Entwicklungsbiologie, Spemannstrasse 35/III, 72076 Tübingen, Germany.

§   To whom correspondence should be addressed. E-mail juerg.mueller{at}tuebingen.mpg.de

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