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Science 27 November 1998:
Vol. 282. no. 5394, pp. 1721 - 1724
DOI: 10.1126/science.282.5394.1721
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Reports

Control of Cyclin Ubiquitination by CDK-Regulated Binding of Hct1 to the Anaphase Promoting Complex

Wolfgang Zachariae, * Michael Schwab, * Kim Nasmyth, Wolfgang Seufert dagger

Proteolysis of mitotic cyclins depends on a multisubunit ubiquitin-protein ligase, the anaphase promoting complex (APC). Proteolysis commences during anaphase, persisting throughout G1 until it is terminated by cyclin-dependent kinases (CDKs) as cells enter S phase. Proteolysis of mitotic cyclins in yeast was shown to require association of the APC with the substrate-specific activator Hct1 (also called Cdh1). Phosphorylation of Hct1 by CDKs blocked the Hct1-APC interaction. The mutual inhibition between APC and CDKs explains how cells suppress mitotic CDK activity during G1 and then establish a period with elevated kinase activity from S phase until anaphase.

W. Zachariae and K. Nasmyth, Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria. M. Schwab and W. Seufert, Institute of Industrial Genetics, University of Stuttgart, Allmandring 31, D-70569 Stuttgart, Germany.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: wolfgang.seufert{at}po.uni-stuttgart.de

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PAN GU: a protein kinase that inhibits S phase and promotes mitosis in early Drosophila development.
D. Fenger, J. Carminati, D. Burney-Sigman, H Kashevsky, J. Dines, L. Elfring, and T. Orr-Weaver (2000)
Development 127, 4763-4774
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Kinetic Analysis of a Molecular Model of the Budding Yeast Cell Cycle.
K. C. Chen, A. Csikasz-Nagy, B. Gyorffy, J. Val, B. Novak, and J. J. Tyson (2000)
Mol. Biol. Cell 11, 369-391
   Abstract »    Full Text »
Regulation of APC Activity by Phosphorylation and Regulatory Factors.
S. Kotani, H. Tanaka, H. Yasuda, and K. Todokoro (1999)
J. Cell Biol. 146, 791-800
   Abstract »    Full Text »    PDF »
Whose end is destruction: cell division and the anaphase-promoting complex.
W. Zachariae and K. Nasmyth (1999)
Genes & Dev. 13, 2039-2058
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