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Science 27 November 1998:
Vol. 282. no. 5394, pp. 1717 - 1721
DOI: 10.1126/science.282.5394.1717
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Reports

Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases

Emmanuelle Caron, Alan Hall *

The complement and immunoglobulin receptors are the major phagocytic receptors involved during infection. However, only immunoglobulin-dependent uptake results in a respiratory burst and an inflammatory response in macrophages. Rho guanosine triphosphatases (molecular switches that control the organization of the actin cytoskeleton) were found to be essential for both types of phagocytosis. Two distinct mechanisms of phagocytosis were identified: Type I, used by the immunoglobulin receptor, is mediated by Cdc42 and Rac, and type II, used by the complement receptor, is mediated by Rho. These results suggest a molecular basis for the different biological consequences that are associated with phagocytosis.

Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, and Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, UK.
*   To whom correspondence should be addressed. E-mail: alan.hall{at}ucl.ac.uk

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Cdc42, Rac1, and Rac2 Display Distinct Patterns of Activation during Phagocytosis.
A. D. Hoppe and J. A. Swanson (2004)
Mol. Biol. Cell 15, 3509-3519
   Abstract »    Full Text »    PDF »
Vav GEFs are required for {beta}2 integrin-dependent functions of neutrophils.
M. A. M. Gakidis, X. Cullere, T. Olson, J. L. Wilsbacher, B. Zhang, S. L. Moores, K. Ley, W. Swat, T. Mayadas, and J. S. Brugge (2004)
J. Cell Biol. 166, 273-282
   Abstract »    Full Text »    PDF »
Positive Regulation of Phagocytosis by SIRP{beta} and Its Signaling Mechanism in Macrophages.
A. Hayashi, H. Ohnishi, H. Okazawa, S. Nakazawa, H. Ikeda, S.-i. Motegi, N. Aoki, S. Kimura, M. Mikuni, and T. Matozaki (2004)
J. Biol. Chem. 279, 29450-29460
   Abstract »    Full Text »    PDF »
Regulation of Phagosome Maturation by Signals from Toll-Like Receptors.
J. M. Blander and R. Medzhitov (2004)
Science 304, 1014-1018
   Abstract »    Full Text »    PDF »
Rho Is Involved in Superoxide Formation during Phagocytosis of Opsonized Zymosans.
J.-S. Kim, B. A. Diebold, J.-I. Kim, J. Kim, J.-Y. Lee, and J.-B. Park (2004)
J. Biol. Chem. 279, 21589-21597
   Abstract »    Full Text »    PDF »
Streptococcal M5 Protein Prevents Neutrophil Phagocytosis by Interfering with CD11b/CD18 Receptor-Mediated Association and Signaling.
M. Weineisen, U. Sjobring, M. Fallman, and T. Andersson (2004)
J. Immunol. 172, 3798-3807
   Abstract »    Full Text »    PDF »
Microtubule motors control membrane dynamics of Salmonella-containing vacuoles.
J. Guignot, E. Caron, C. Beuzon, C. Bucci, J. Kagan, C. Roy, and D. W. Holden (2004)
J. Cell Sci. 117, 1033-1045
   Abstract »    Full Text »    PDF »
Gelsolin Mediates Collagen Phagocytosis through a Rac-dependent Step.
P. D. Arora, M. Glogauer, A. Kapus, D. J. Kwiatkowski, and C. A. McCulloch (2004)
Mol. Biol. Cell 15, 588-599
   Abstract »    Full Text »    PDF »
Regulated Exocytosis in Neuroendocrine Cells: A Role for Subplasmalemmal Cdc42/N-WASP-induced Actin Filaments.
S. Gasman, S. Chasserot-Golaz, M. Malacombe, M. Way, and M.-F. Bader (2004)
Mol. Biol. Cell 15, 520-531
   Abstract »    Full Text »    PDF »
GTPases and reactive oxygen species: switches for killing and signaling.
E. Werner (2004)
J. Cell Sci. 117, 143-153
   Abstract »    Full Text »    PDF »
Engulfment of Apoptotic Cells Is Negatively Regulated by Rho-mediated Signaling.
A.-C. Tosello-Trampont, K. Nakada-Tsukui, and K. S. Ravichandran (2003)
J. Biol. Chem. 278, 49911-49919
   Abstract »    Full Text »    PDF »
Enhanced Phagocytosis of Candida Species Mediated by Opsonization with a Recombinant Human Antibody Single-Chain Variable Fragment.
M. Wellington, J. M. Bliss, and C. G. Haidaris (2003)
Infect. Immun. 71, 7228-7231
   Abstract »    Full Text »    PDF »
Gonococcal Phospholipase D Modulates the Expression and Function of Complement Receptor 3 in Primary Cervical Epithelial Cells.
J. L. Edwards, D. D. Entz, and M. A. Apicella (2003)
Infect. Immun. 71, 6381-6391
   Abstract »    Full Text »    PDF »
An SH2 Domain-dependent, Phosphotyrosine-independent Interaction between Vav1 and the Mer Receptor Tyrosine Kinase: A MECHANISM FOR LOCALIZING GUANINE NUCLEOTIDE-EXCHANGE FACTOR ACTION.
N. P. Mahajan and H. S. Earp (2003)
J. Biol. Chem. 278, 42596-42603
   Abstract »    Full Text »    PDF »


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