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Science 27 November 1998:
Vol. 282. no. 5394, pp. 1711 - 1714
DOI: 10.1126/science.282.5394.1711
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Reports

Zebrafish hox Clusters and Vertebrate Genome Evolution

Angel Amores, Allan Force, Yi-Lin Yan, Lucille Joly, Chris Amemiya, Andreas Fritz, Robert K. Ho, James Langeland, Victoria Prince, Yan-Ling Wang, Monte Westerfield, Marc Ekker, * John H. Postlethwait *dagger

HOX genes specify cell fate in the anterior-posterior axis of animal embryos. Invertebrate chordates have one HOX cluster, but mammals have four, suggesting that cluster duplication facilitated the evolution of vertebrate body plans. This report shows that zebrafish have seven hox clusters. Phylogenetic analysis and genetic mapping suggest a chromosome doubling event, probably by whole genome duplication, after the divergence of ray-finned and lobe-finned fishes but before the teleost radiation. Thus, teleosts, the most species-rich group of vertebrates, appear to have more copies of these developmental regulatory genes than do mammals, despite less complexity in the anterior-posterior axis.

A. Amores, A. Force, Y.-L. Yan, Y.-L. Wang, M. Westerfield, J. H. Postlethwait, Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA. L. Joly and M. Ekker, Loeb Institute of Medical Research, Ottawa Civic Hospital, Ottawa, Ontario K1Y 4E9, Canada. C. Amemiya, Center for Human Genetics, Boston University School of Medicine, Boston, MA 02118, USA. A. Fritz, Department of Biology, Emory University, Atlanta, GA 30322, USA. R. K. Ho, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. J. Langeland, Biology Department, Kalamazoo College, Kalamazoo, MI 49006, USA. V. Prince, Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA.
*   The experiments reported here were conducted in the laboratories of these authors.

dagger    To whom correspondence should be addressed.

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