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Science 27 November 1998:
Vol. 282. no. 5394, pp. 1711 - 1714
DOI: 10.1126/science.282.5394.1711
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Reports

Zebrafish hox Clusters and Vertebrate Genome Evolution

Angel Amores, Allan Force, Yi-Lin Yan, Lucille Joly, Chris Amemiya, Andreas Fritz, Robert K. Ho, James Langeland, Victoria Prince, Yan-Ling Wang, Monte Westerfield, Marc Ekker, * John H. Postlethwait *dagger

HOX genes specify cell fate in the anterior-posterior axis of animal embryos. Invertebrate chordates have one HOX cluster, but mammals have four, suggesting that cluster duplication facilitated the evolution of vertebrate body plans. This report shows that zebrafish have seven hox clusters. Phylogenetic analysis and genetic mapping suggest a chromosome doubling event, probably by whole genome duplication, after the divergence of ray-finned and lobe-finned fishes but before the teleost radiation. Thus, teleosts, the most species-rich group of vertebrates, appear to have more copies of these developmental regulatory genes than do mammals, despite less complexity in the anterior-posterior axis.

A. Amores, A. Force, Y.-L. Yan, Y.-L. Wang, M. Westerfield, J. H. Postlethwait, Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA. L. Joly and M. Ekker, Loeb Institute of Medical Research, Ottawa Civic Hospital, Ottawa, Ontario K1Y 4E9, Canada. C. Amemiya, Center for Human Genetics, Boston University School of Medicine, Boston, MA 02118, USA. A. Fritz, Department of Biology, Emory University, Atlanta, GA 30322, USA. R. K. Ho, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. J. Langeland, Biology Department, Kalamazoo College, Kalamazoo, MI 49006, USA. V. Prince, Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA.
*   The experiments reported here were conducted in the laboratories of these authors.

dagger    To whom correspondence should be addressed.

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K. Naruse, M. Tanaka, K. Mita, A. Shima, J. Postlethwait, and H. Mitani (2004)
Genome Res. 14, 820-828
   Abstract »    Full Text »    PDF »
Origins, Lineage-Specific Expansions, and Multiple Losses of Tyrosine Kinases in Eukaryotes.
S.-H. Shiu and W.-H. Li (2004)
Mol. Biol. Evol. 21, 828-840
   Abstract »    Full Text »    PDF »
Gene Conversion and the Evolution of Protocadherin Gene Cluster Diversity.
J. P. Noonan, J. Grimwood, J. Schmutz, M. Dickson, and R. M. Myers (2004)
Genome Res. 14, 354-366
   Abstract »    Full Text »    PDF »
Segmental development of reticulospinal and branchiomotor neurons in lamprey: insights into the evolution of the vertebrate hindbrain.
Y. Murakami, M. Pasqualetti, Y. Takio, S. Hirano, F. M. Rijli, and S. Kuratani (2004)
Development 131, 983-995
   Abstract »    Full Text »    PDF »
Major events in the genome evolution of vertebrates: Paranome age and size differ considerably between ray-finned fishes and land vertebrates.
K. Vandepoele, W. De Vos, J. S. Taylor, A. Meyer, and Y. Van de Peer (2004)
PNAS 101, 1638-1643
   Abstract »    Full Text »    PDF »
Identification of a Second egfr Gene in Xiphophorus Uncovers an Expansion of the Epidermal Growth Factor Receptor Family in Fish.
A. Gomez, J.-N. Volff, U. Hornung, M. Schartl, and C. Wellbrock (2004)
Mol. Biol. Evol. 21, 266-275
   Abstract »    Full Text »    PDF »
Developmental Roles of Pufferfish Hox Clusters and Genome Evolution in Ray-Fin Fish.
A. Amores, T. Suzuki, Y.-L. Yan, J. Pomeroy, A. Singer, C. Amemiya, and J. H. Postlethwait (2004)
Genome Res. 14, 1-10
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Bichir HoxA Cluster Sequence Reveals Surprising Trends in Ray-Finned Fish Genomic Evolution.
C.-h. Chiu, K. Dewar, G. P. Wagner, K. Takahashi, F. Ruddle, C. Ledje, P. Bartsch, J.-L. Scemama, E. Stellwag, C. Fried, et al. (2004)
Genome Res. 14, 11-17
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Identification of Nogo-66 Receptor (NgR) and Homologous Genes in Fish.
M. Klinger, J. S. Taylor, T. Oertle, M. E. Schwab, C. A. O. Stuermer, and H. Diekmann (2004)
Mol. Biol. Evol. 21, 76-85
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Identification of Duplicated Fourth {alpha}2-Adrenergic Receptor Subtype by Cloning and Mapping of Five Receptor Genes in Zebrafish.
J. O. Ruuskanen, H. Xhaard, A. Marjamaki, E. Salaneck, T. Salminen, Y.-L. Yan, J. H. Postlethwait, M. S. Johnson, D. Larhammar, and M. Scheinin (2004)
Mol. Biol. Evol. 21, 14-28
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Divergence of Hoxc8 early enhancer parallels diverged axial morphologies between mammals and fishes.
S. Anand, W. C. H. Wang, D. R. Powell, S. A. Bolanowski, J. Zhang, C. Ledje, A. B. Pawashe, C. T. Amemiya, and C. S. Shashikant (2003)
PNAS 100, 15666-15669
   Abstract »    Full Text »    PDF »
The amphioxus Hairy family: differential fate after duplication.
C. Minguillon, S. Jimenez-Delgado, G. Panopoulou, and J. Garcia-Fernandez (2003)
Development 130, 5903-5914
   Abstract »    Full Text »    PDF »
Hox cluster duplications and the opportunity for evolutionary novelties.
G. P. Wagner, C. Amemiya, and F. Ruddle (2003)
PNAS 100, 14603-14606
   Abstract »    Full Text »    PDF »


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